BioPAX pathway converted from "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol" in the Reactome database.18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol

18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol

Exonuclease activity of the exosome (Preti et al. 2013) and endonuclease activity of NOB1 (inferred from yeast, Pertschy et al. 2009) process the 3' end of precursor rRNA (pre-rRNA) 18SE to yield mature 18S rRNA. During the processing, pre-rRNA 18SE is bound in the pre-40S ribosome subunit, which contains ribosomal proteins and processing factors such as NOB1 and BYSL. The pre-40S subunit is exported from the nucleus to the cytosol where processing factors are released and recycled back to the nucleus. The kinases RIOK1, RIOK2, CSNK1D and CSNK1E are associated with the pre-40S rRNA subunit in both the nucleus and cytosol and their kinase activity is required for recycling of processing factors back to the nucleus (Zemp et al. 2009, Zemp et al. 2014). RIOK1 and RIOK2 are also required for 18SE processing (Widmann et al. 2012, Zemp et al. 2009). RIOK3 (RIO3) is a cytosolic kinase that associates with the pre-40S ribosomal particle after export from the nucleus and is required for release of processing factors (Baumas et al. 2012).

Authored: May, Bruce, 2015-08-16Reviewed: Vincent, Nicholas G, 2016-01-30Edited: May, Bruce, 2015-08-16

Reactome DB_ID: 6791522

cytosolGO0005829

UniProt:O14730 RIOK3

RIOK3

RIOK3SUDDFUNCTION Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).SUBUNIT Interacts with CASP10 (PubMed:19557502). Interacts with IRF3; RIOK3 probybly mediates the interaction of TBK1 with IRF3 (PubMed:24807708). Associated with 40S pre-ribosomal particles.TISSUE SPECIFICITY Widely expressed.PTM Autophosphorylated (in vitro).SIMILARITY Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

Reactomehttp://www.reactome.orgHomo sapiens

NCBI Taxonomy9606UniProtO14730

Chain Coordinates

EQUAL

519

EQUAL

Reactome DB_ID: 6791531

nucleoplasmGO000565418SE pre-40S particle [nucleoplasm]

18SE pre-40S particle

Reactome DB_ID: 6790663

UniProt:P46781 RPS9

RPS9

RPS9SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.SIMILARITY Belongs to the universal ribosomal protein uS4 family.

UniProtP46781

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194

EQUAL

Reactome DB_ID: 6790655

UniProt:P15880 RPS2

RPS2

RPS4RPS2PTM Citrullinated by PADI4 in the Arg/Gly-rich region.PTM Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.SIMILARITY Belongs to the universal ribosomal protein uS5 family.

UniProtP15880

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293

EQUAL

Reactome DB_ID: 6791209

UniProt:P62266 RPS23

RPS23

RPS23FUNCTION Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28257692, PubMed:23636399, PubMed:25957688, PubMed:25901680). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:23636399, PubMed:25957688, PubMed:25901680). Plays an important role in translational accuracy (PubMed:28257692).SUBUNIT Component of the 40S small ribosomal subunit.PTM Hydroxylation at Pro-62 affects translation termination efficiency.SIMILARITY Belongs to the universal ribosomal protein uS12 family.

UniProtP62266

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143

EQUAL

Reactome DB_ID: 6798734

UniProt:P62979 RPS27A

RPS27A

UBA80RPS27AUBCEP1SUBUNIT Ribosomal protein S27a is part of the 40S ribosomal subunit.MISCELLANEOUS Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.MISCELLANEOUS For a better understanding, features related to ubiquitin are only indicated for the first chain.SIMILARITY In the N-terminal section; belongs to the ubiquitin family.SIMILARITY In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.

UniProtP62979

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156

EQUAL

Reactome DB_ID: 5696801

UniProt:O75818 RPP40

RPP40

RPP40RNASEP1FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).SUBUNIT Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:9630247, PubMed:16723659, PubMed:28115465, PubMed:30454648). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:9630247, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).

UniProtO75818

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363

EQUAL

Reactome DB_ID: 6791203

UniProt:P62241 RPS8

RPS8

RPS8OK/SW-cl.83SUBUNIT Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.SIMILARITY Belongs to the eukaryotic ribosomal protein eS8 family.

UniProtP62241

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208

EQUAL

Reactome DB_ID: 6798701

UniProt:P62269 RPS18

RPS18

RPS18D6S218EFUNCTION Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.SIMILARITY Belongs to the universal ribosomal protein uS13 family.

UniProtP62269

EQUAL

152

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Reactome DB_ID: 6791182

UniProt:P61247 RPS3A

RPS3A

MFTLRPS3AFTE1FUNCTION May play a role during erythropoiesis through regulation of transcription factor DDIT3.SUBUNIT Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.SIMILARITY Belongs to the eukaryotic ribosomal protein eS1 family.

UniProtP61247

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264

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Reactome DB_ID: 6791540

UniProt:Q9NRX1 PNO1

PNO1

PNO1FUNCTION Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA (PubMed:25851604).TISSUE SPECIFICITY Expressed in liver, lung, spleen and kidney. Weakly expressed in thymus, testis and ovary. Weakly or not expressed in heart, brain, skeletal muscle, placenta, pancreas, prostate, small intestine, colon and peripheral blood leukocytes.SIMILARITY Belongs to the PNO1 family.

UniProtQ9NRX1

EQUAL

252

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868825

RPS4X,RPS4Y1,RPS4Y2 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS4Y1 [nucleoplasm]RPS4X [nucleoplasm]

UniProtP22090UniProtP62701

Reactome DB_ID: 6791566

UniProt:Q96GA3 LTV1

LTV1

LTV1C6orf93SIMILARITY Belongs to the LTV1 family.

UniProtQ96GA3

EQUAL

475

EQUAL

Reactome DB_ID: 6798715

UniProt:P25398 RPS12

RPS12

RPS12SIMILARITY Belongs to the eukaryotic ribosomal protein eS12 family.

UniProtP25398

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132

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 8868823

RPS27,RPS27L [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS27 [nucleoplasm]

UniProtP42677

Reactome DB_ID: 5226890

UniProt:Q9BRS2 RIOK1

RIOK1

RIOK1RIO1FUNCTION Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503).SUBUNIT Associates with the precursor of the 40S ribosome subunit. Interacts (via its N-terminus) with PRMT5 (via its N-terminus) (PubMed:22072790, PubMed:21081503). Interacts with WDR77 (PubMed:22072790). Found in a PRMT5 complex composed of PRMT5, WDR77 and RIOK1 (PubMed:21081503). Interacts (via its C-terminus) with NCL; this interaction targets NCL for PRTM5 methylation (PubMed:21081503).SIMILARITY Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

UniProtQ9BRS2

EQUAL

568

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Reactome DB_ID: 5696782

UniProt:Q9BUL9 RPP25

RPP25

RPP25FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:12003489, PubMed:16723659, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).SUBUNIT Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:12003489, PubMed:15096576, PubMed:16723659, PubMed:20215441, PubMed:28115465, PubMed:30454648). RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:12003489, PubMed:16723659, PubMed:20215441, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:15096576, PubMed:16723659, PubMed:28115465). POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA (PubMed:20215441, PubMed:29625199).SIMILARITY Belongs to the histone-like Alba family.

UniProtQ9BUL9

EQUAL

199

EQUAL

Reactome DB_ID: 6791204

18SE pre-rRNA [nucleoplasm]

18SE pre-rRNA

Reactome DB_ID: 5696794

UniProt:O95059 RPP14

RPP14

RPP14FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.SUBUNIT RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:10024167, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648).MISCELLANEOUS This protein is produced by a bicistronic gene which also produces the HTD2 protein from an overlapping reading frame.SIMILARITY Belongs to the eukaryotic/archaeal RNase P protein component 2 family.

UniProtO95059

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124

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Reactome DB_ID: 6791202

UniProt:P62857 RPS28

RPS28

RPS28SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS28 family.

UniProtP62857

EQUAL

Reactome DB_ID: 6791526

UniProt:Q13895 BYSL

BYSL

ENP1BYSLFUNCTION Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos.SUBUNIT Binds trophinin, tastin and cytokeratins.TISSUE SPECIFICITY Found in the placenta from the sixth week of pregnancy. Was localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the level decreased and then disappeared from placental villi.MISCELLANEOUS HeLa cells lacking BYSL show a delay in the processing of the 18S rRNA component of the 40S ribosomal subunit. HT-H cells lacking BYSL show trophinin-independent signaling through ERBB4.SIMILARITY Belongs to the bystin family.

UniProtQ13895

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437

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Reactome DB_ID: 6798727

UniProt:P60866 RPS20

RPS20

RPS20SUBUNIT Component of the 40S small ribosomal subunit.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).PTM Ufmylated by UFL1.SIMILARITY Belongs to the universal ribosomal protein uS10 family.

UniProtP60866

EQUAL

119

EQUAL

Reactome DB_ID: 6798722

UniProt:P08865 RPSA

RPSA

LAMBRRPSALAMR1FUNCTION Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.FUNCTION (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.FUNCTION (Microbial infection) Acts as a receptor for the Dengue virus.FUNCTION (Microbial infection) Acts as a receptor for the Sindbis virus.FUNCTION (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.FUNCTION (Microbial infection) Acts as a receptor for the pathogenic prion protein.FUNCTION (Microbial infection) Acts as a receptor for bacteria.SUBUNIT Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.SUBUNIT (Microbial infection) 67LR interacts with capsid protein of Adeno-associated virus 2,3,8 and 9.SUBUNIT (Microbial infection) 67LR interacts with envelope protein of dengue virus.SUBUNIT (Microbial infection) 6s7LR interacts with E2 glycoprotein of Sindbis and Venezuelan equine encephalitis virus (PubMed:8764073, PubMed:1385835).PTM Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).PTM Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.MISCELLANEOUS This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage.MISCELLANEOUS It is thought that in vertebrates 37/67 kDa laminin receptor acquired a dual function during evolution. It developed from the ribosomal protein SA, playing an essential role in the protein biosynthesis lacking any laminin binding activity, to a cell surface receptor with laminin binding activity.SIMILARITY Belongs to the universal ribosomal protein uS2 family.

UniProtP08865

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295

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Reactome DB_ID: 5696779

UniProt:P78346 RPP30

RPP30

RPP30RNASEP2FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).SUBUNIT Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:9037013, PubMed:9630247, PubMed:16723659, PubMed:30454648). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:9037013, PubMed:9630247, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).MISCELLANEOUS Autoantibodies against RPP30 are found in sera from scleroderma patients.SIMILARITY Belongs to the eukaryotic/archaeal RNase P protein component 3 family.

UniProtP78346

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268

EQUAL

Reactome DB_ID: 5696791

UniProt:P78345 RPP38

RPP38

RPP38FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:30454648). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465).SUBUNIT Component of nuclear RNase P and RNase MRP ribonucleoproteins (PubMed:9037013, PubMed:10444065, PubMed:9630247, PubMed:16723659, PubMed:30454648). RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:9037013, PubMed:9630247, PubMed:10444065, PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648). Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5 (PubMed:16723659, PubMed:28115465).MISCELLANEOUS Autoantibodies against RPP38 are found in sera from scleroderma patients.SIMILARITY Belongs to the eukaryotic ribosomal protein eL8 family.

UniProtP78345

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283

EQUAL

Reactome DB_ID: 6791188

UniProt:P46782 RPS5

RPS5

RPS5SIMILARITY Belongs to the universal ribosomal protein uS7 family.

UniProtP46782

EQUAL

204

EQUAL

Reactome DB_ID: 6798719

UniProt:P08708 RPS17

RPS17

RPS17RPS17LSIMILARITY Belongs to the eukaryotic ribosomal protein eS17 family.

UniProtP08708

EQUAL

135

EQUAL

Reactome DB_ID: 6798717

UniProt:P62861 FAU

FAU

FAUMISCELLANEOUS This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein.SIMILARITY Belongs to the eukaryotic ribosomal protein eS30 family.

UniProtP62861

EQUAL

Reactome DB_ID: 6791536

UniProt:Q9ULX3 NOB1

NOB1

NOB1PNOB1PSMD8BP1MSTP158ART4FUNCTION May play a role in mRNA degradation (Probable). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity).SUBUNIT Interacts with UPF2 (Probable). Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex) (PubMed:15231747).TISSUE SPECIFICITY Detected in liver, lung, placenta, endothelial cells and spleen.SIMILARITY Belongs to the NOB1 family.

UniProtQ9ULX3

EQUAL

412

EQUAL

Reactome DB_ID: 6791198

UniProt:P62277 RPS13

RPS13

RPS13SIMILARITY Belongs to the universal ribosomal protein uS15 family.

UniProtP62277

EQUAL

151

EQUAL

Reactome DB_ID: 6798733

UniProt:P46783 RPS10

RPS10

RPS10FUNCTION Component of the 40S ribosomal subunit.SUBUNIT Component of the small ribosomal subunit. Interacts with PRMT5. The methylated form interacts with NPM1.PTM Methylated by PRMT5. Methylation is necessary for its interaction with NPS1, its localization in the granular component (GC) region of the nucleolus, for the proper assembly of ribosomes, protein synthesis and optimal cell proliferation.PTM Monoubiquitinated by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).SIMILARITY Belongs to the eukaryotic ribosomal protein eS10 family.

UniProtP46783

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165

EQUAL

Reactome DB_ID: 6791574

UniProt:Q2NL82 TSR1

TSR1

KIAA1401TSR1FUNCTION Required during maturation of the 40S ribosomal subunit in the nucleolus.SIMILARITY Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.

UniProtQ2NL82

EQUAL

804

EQUAL

Reactome DB_ID: 6791191

UniProt:P62244 RPS15A

RPS15A

RPS15AOK/SW-cl.82FUNCTION Structural component of the ribosome (PubMed:23636399). Required for proper erythropoiesis (PubMed:27909223).SUBUNIT Component of the 40S ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uS8 family.

UniProtP62244

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130

EQUAL

Reactome DB_ID: 6791196

UniProt:P62249 RPS16

RPS16

RPS16SIMILARITY Belongs to the universal ribosomal protein uS9 family.

UniProtP62249

EQUAL

146

EQUAL

Reactome DB_ID: 6791212

UniProt:P62280 RPS11

RPS11

RPS11PTM Citrullinated by PADI4.SIMILARITY Belongs to the universal ribosomal protein uS17 family.

UniProtP62280

EQUAL

158

EQUAL

Reactome DB_ID: 6798714

UniProt:P23396 RPS3

RPS3

OK/SW-cl.26RPS3FUNCTION Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).ACTIVITY REGULATION Endonuclease activity is inhibited by MgCl2 on apurinic/apyrimidinic DNA but not on UV-irradiated DNA.SUBUNIT Component of the 40S small ribosomal subunit (PubMed:8706699). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Interacts with HNRPD (PubMed:24423872). Interacts with PRMT1; the interaction methylates RPS3 (PubMed:19460357). Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed:21968017). Interacts with UBC9 (PubMed:21968017). Interacts with CDK1; the interaction phosphorylates RPS3 (PubMed:21871177). Interacts with PRKCD; the interaction phosphorylates RPS3 (PubMed:19059439). Interacts with PKB/AKT; the interaction phosphorylates RPS3 (PubMed:20605787). Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity (PubMed:15518571). Interacts with UNG; the interaction increases the uracil excision activity of UNG1 (PubMed:18973764). Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels (PubMed:16314389). Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion (PubMed:23911537). Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex (PubMed:18045535). Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA (PubMed:24457201). Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus (PubMed:21399639). Interacts (via KH domain) with MDM2 and TP53 (PubMed:19656744). Interacts with TRADD (PubMed:22510408). Interacts (via N-terminus) with E.coli O157:H7 (strain EDL933) nleH1 and nleH2; the interaction with nleH1 inhibits phosphorylation by IKKB, reduces RPS3 nuclear abundance and inhibits transcriptional activation by the NF-kappa-B p65-p50 complex (PubMed:20041225, PubMed:21399639). Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon (PubMed:19541769). Interacts with CRY1 (By similarity).PTM Methylation by PRMT1 is required for import into the nucleolus and for ribosome assembly.PTM Sumoylation by SUMO1 enhances protein stability through increased resistance to proteolysis. Sumoylation occurs at one or more of the three consensus sites, Lys-18, Lys-214 and Lys-230.PTM Phosphorylation at Thr-221 by CDK1 occurs mainly in G2/M phase (PubMed:21871177). Phosphorylation by PRKCD occurs on a non-ribosomal-associated form which results in translocation of RPS3 to the nucleus and enhances its endonuclease activity (PubMed:19059439). Phosphorylated on Ser-209 by IKKB in response to activation of the NF-kappa-B p65-p50 complex which enhances the association of RPS3 with importin-alpha and mediates the nuclear translocation of RPS3 (PubMed:21399639). Phosphorylation by MAPK is required for translocation to the nucleus following exposure of cells to DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Phosphorylation by PKB/AKT mediates RPS3 nuclear translocation, enhances RPS3 endonuclease activity and suppresses RPS3-induced neuronal apoptosis (PubMed:20605787).PTM Ubiquitinated (PubMed:16314389). This is prevented by interaction with HSP90 which stabilizes the protein (PubMed:16314389). Monoubiquitinated at Lys-214 by ZNF598 when a ribosome has stalled during translation of poly(A) sequences, leading to preclude synthesis of a long poly-lysine tail and initiate the ribosome quality control (RQC) pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843).PTM Ufmylated by UFL1.SIMILARITY Belongs to the universal ribosomal protein uS3 family.

UniProtP23396

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UniProt:P62263 RPS14

RPS14

RPS14PRO2640SIMILARITY Belongs to the universal ribosomal protein uS11 family.

UniProtP62263

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Reactome DB_ID: 5696796

UniProt:Q9H633 RPP21

RPP21

RPP21C6orf135CAT60FUNCTION Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.SUBUNIT RNase P consists of a catalytic RNA moiety and about 10 protein subunits; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40 (PubMed:16723659, PubMed:30454648). Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA (PubMed:30454648).SIMILARITY Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

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Reactome DB_ID: 6791569

UniProt:Q9BVS4 RIOK2

RIOK2

RIOK2RIO2FUNCTION Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).SUBUNIT Associated with late 40S pre-ribosomal particles (PubMed:16037817, PubMed:21081503). Interacts with PLK1 (via its N-terminus) (PubMed:21880710).PTM Autophosphorylated (in vitro) (PubMed:19564402, PubMed:21880710). Phosphorylation at Ser-335, Ser-380, Ser-548 by PLK1 affects the timing of the metaphase-anaphase transition (PubMed:21880710).SIMILARITY Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

UniProtQ9BVS4

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Reactome DB_ID: 6798707

UniProt:P62851 RPS25

RPS25

RPS25SIMILARITY Belongs to the eukaryotic ribosomal protein eS25 family.

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Reactome DB_ID: 6790635

UniProt:P62081 RPS7

RPS7

RPS7FUNCTION Required for rRNA maturation.SUBUNIT Binds IPO9 with high affinity (PubMed:11823430). Interacts with NEK6 (PubMed:20873783). Interacts with DESI2 (PubMed:28483520).PTM Phosphorylated by NEK6.PTM Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization.SIMILARITY Belongs to the eukaryotic ribosomal protein eS7 family.

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Reactome DB_ID: 6798725

UniProt:P62273 RPS29

RPS29

RPS29SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the universal ribosomal protein uS14 family.

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Reactome DB_ID: 6791186

UniProt:P62847 RPS24

RPS24

RPS24FUNCTION Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.TISSUE SPECIFICITY Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels.SIMILARITY Belongs to the eukaryotic ribosomal protein eS24 family.

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Reactome DB_ID: 421305

UniProt:P48730 CSNK1D

CSNK1D

CSNK1DHCKIDFUNCTION Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.ACTIVITY REGULATION Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation. Repressed by 3-[(2,4,6-trimethoxyphenyl)methylidenyl]-indolin-2-one (IC261), N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide (CKI-7), 4-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide (D4476), 3,4-diaryl-isoxazoles and -imidazoles, and 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl) pyrimidin-2-ylamine (PF670462, PF670).SUBUNIT Monomer (PubMed:22168824, PubMed:23106386). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with DNMT1 and MAP1A (By similarity). Interacts directly with PER1 and PER2 which may lead to their degradation (PubMed:11165242). Interacts with MAPT/TAU (PubMed:14761950). Interacts with SNAPIN (By similarity). Interacts with DBNDD2 (PubMed:16618118). Interacts with AIB1/NCOA3 and ESR1 (PubMed:19339517). Interacts with AKAP9/AKAP450; this interaction promotes centrosomal subcellular location (PubMed:12270714). Binds to tubulins in mitotic cells upon DNA damage (PubMed:10826492). Interacts with GJA1 (PubMed:12270943). Interacts with DDX3X; this interaction enhances CSNK1D kinase activity in vitro, but it is unclear whether this interaction is physiologically relevant (PubMed:29222110).TISSUE SPECIFICITY Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. However, kinase activity is not uniform, with highest kinase activity in splenocytes. In blood, highly expressed in hemopoietic cells and mature granulocytes. Also found in monocytes and lymphocytes.DEVELOPMENTAL STAGE Highly present in extravillous trophoblast cells, which are present at the placenta implantation site and invade the decidua and decidual vessels.PTM Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.MISCELLANEOUS May be involved in Alzheimer disease by phosphorylating MAPT/TAU.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.CAUTION Was shown to phosphorylate and activate DCK in vitro but probably not in vivo.

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UniProt:P62854 RPS26

RPS26

RPS26SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS26 family.

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Reactome DB_ID: 421306

UniProt:P49674 CSNK1E

CSNK1E

CSNK1EFUNCTION Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.ACTIVITY REGULATION Phosphorylation leads to a decrease of the catalytic activity.SUBUNIT Monomer (PubMed:23106386). Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, ARTNL/BMAL1 or ARTNL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins (By similarity). Interacts with PER1 (PubMed:10790862). Interacts with ANKRD6 (By similarity). Interacts with DBNDD2 (PubMed:16618118). Interacts with LRP5 and LRP6 (PubMed:16513652). Interacts with SOCS3 (PubMed:15070676). Interacts with SNAI1 (via zinc fingers) (PubMed:20305697). Interacts with DDX3X; this interaction greatly enhances CSNK1E affinity for ATP and DVL2 phosphorylation, but inhibits DDX3X ATPase/helicase activity. In the presence of RNA, the interaction is decreased (PubMed:23413191, PubMed:29222110).TISSUE SPECIFICITY Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes.INDUCTION Down-regulated during granulocytic differentiation.PTM Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.SIMILARITY Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

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Reactome DB_ID: 6798710

UniProt:P39019 RPS19

RPS19

RPS19FUNCTION Required for pre-rRNA processing and maturation of 40S ribosomal subunits.SUBUNIT Interacts with RPS19BP1.TISSUE SPECIFICITY Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.SIMILARITY Belongs to the eukaryotic ribosomal protein eS19 family.

UniProtP39019

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Reactome DB_ID: 6790606

UniProt:P62753 RPS6

RPS6

OK/SW-cl.2RPS6FUNCTION May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.PTM Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the preinitiation complex.PTM Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8.SIMILARITY Belongs to the eukaryotic ribosomal protein eS6 family.

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UniProt:P62841 RPS15

RPS15

RPS15RIGSIMILARITY Belongs to the universal ribosomal protein uS19 family.

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Reactome DB_ID: 6798732

UniProt:P63220 RPS21

RPS21

RPS21SUBUNIT Component of the 40S small ribosomal subunit.SIMILARITY Belongs to the eukaryotic ribosomal protein eS21 family.

UniProtP63220

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Reactome Database ID Release 756791531Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6791531ReactomeR-HSA-6791531

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6791531.2

Reactome DB_ID: 6791525

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Reactome DB_ID: 72392

40S ribosomal complex [cytosol]

40S ribosomal complex

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EMBL:X03205 18S rRNA18S rRNA

EMBLX03205

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Converted from EntitySet in Reactome

Reactome DB_ID: 8868839

RPS27,RPS27L [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS27 [cytosol]

Reactome DB_ID: 72351

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Converted from EntitySet in Reactome

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RPS4X,RPS4Y1,RPS4Y2 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRPS4X [cytosol]RPS4Y1 [cytosol]

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Reactome Database ID Release 7572392Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=72392ReactomeR-HSA-72392

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-72392.2

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PHYSIOL-LEFT-TO-RIGHT

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GO0004521

GO molecular function

Reactome Database ID Release 756791528Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6791528Reactome Database ID Release 756791223Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6791223ReactomeR-HSA-6791223

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6791223.523482395Pubmed2013Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNAPreti, MilenaO'Donohue, Marie-FrançoiseMontel-Lehry, NathalieBortolin-Cavaillé, Marie-LineChoesmel, ValérieGleizes, Pierre-EmmanuelNucleic Acids Res. 41:4709-2322072790Pubmed2012The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunitsWidmann, BarbaraWandrey, FranziskaBadertscher, LukasWyler, EmanuelPfannstiel, JensZemp, IvoKutay, UlrikeMol. Biol. Cell 23:22-3519564402Pubmed2009Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2Zemp, IvoWild, ThomasO'Donohue, Marie-FrançoiseWandrey, FranziskaWidmann, BarbaraGleizes, Pierre-EmmanuelKutay, UlrikeJ. Cell Biol. 185:1167-8025525153Pubmed2015WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNAHaag, SaraKretschmer, JensBohnsack, Markus TRNA 21:180-716037817Pubmed2005Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cellsRouquette, JacquesChoesmel, ValérieGleizes, Pierre-EmmanuelEMBO J. 24:2862-7221097556Pubmed2011Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assembliesWyler, EmanuelZimmermann, MirjamWidmann, BarbaraGstaiger, MatthiasPfannstiel, JensKutay, UlrikeZemp, IvoRNA 17:189-20024424021Pubmed2014CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturationZemp, IvoWandrey, FranziskaRao, SanjanaAshiono, CarolineWyler, EmanuelMontellese, ChristianKutay, UlrikeJ. Cell. Sci. 127:1242-5320805244Pubmed2011Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammalsCarron, CoralieO'Donohue, Marie-FrançoiseChoesmel, ValérieFaubladier, MarlèneGleizes, Pierre-EmmanuelNucleic Acids Res. 39:280-9119801658Pubmed2009RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1Pertschy, BrigitteSchneider, ClaudiaGnädig, MarénSchäfer, ThorstenTollervey, DavidHurt, EdJ. Biol. Chem. 284:35079-91

ACTIVATION

Reactome Database ID Release 759023929Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9023929ReactomeR-HSA-9023929

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9023929.1

Reactome DB_ID: 380315

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Reactome Database ID Release 758949027Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8949027ReactomeR-HSA-8949027

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8949027.1

Reactome DB_ID: 6790981

UniProt:O43709 BUD23

BUD23

MERM1HUSSY-03WBSCR22PP3381BUD23FUNCTION S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity (PubMed:25851604). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity (PubMed:25851604). Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (PubMed:24086612). Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors (PubMed:24488492). Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements (PubMed:24488492). Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro (PubMed:24488492).SUBUNIT Heterodimer with TRMT112; this heterodimerization is necessary for the metabolic stability and activity of the catalytic subunit BUD23 (PubMed:25851604). Interacts with GRIP1.TISSUE SPECIFICITY Widely expressed, with high levels in heart, skeletal muscle and kidney. Detected at high levels in bronchial brushings and in normal lung (at protein level). In fetal lung tissue, expressed in the developing bronchial lumen lining cells (at protein level). Tends to be down-regulated in lungs affected by inflammatory diseases or neoplasia (at protein level). Expressed in immune cells, including B and T lymphocytes and macrophages.INDUCTION Up-regulated in CD8+ T lymphocytes by treatment with anti-CD3 and in B lymphocytes by treatment with CD40 ligand and anti-B cell receptor antibody. In macrophages, no induction following LPS treatment. Down-regulated by a combined treatment with TNF and IFNG (at protein level).PTM May be ubiquitinated and targeted to degradation in response to proinflammatory cytokine signaling.DISEASE BUD23 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BUD23 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.SIMILARITY Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.

UniProtO43709

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Reactome Database ID Release 759023927Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9023927ReactomeR-HSA-9023927

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9023927.1

Reactome DB_ID: 205877

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