BioPAX pathway converted from "LDHAL6B reduces PYR to LACT" in the Reactome database.1.1.1.27LDHAL6B reduces PYR to LACTLDHAL6B reduces PYR to LACTLDHAL6B (L-lactate dehydrogenase A-like 6B) catalyzes the reaction of PYR (pyruvate) and NADH + H+ to form LACT (lactate) and NAD+. The LDHAL6B protein is the inferred product of an open reading frame transcribed in the testis (Wang et al. 2005). Its mitochondrial localization is inferred from the presence of a mitochondrial localization sequence at its amino terminus (Holmes and Goldberg 2009). A physiological role for lactate formation from the abundant pyruvate and NADH expected in rapidly respiring mitochondria is not straightforward to imagine, however.Authored: D'Eustachio, Peter, 2015-11-09Reviewed: Jassal, Bijay, 2015-11-09Edited: D'Eustachio, Peter, 2015-11-09Reactome DB_ID: 1135291mitochondrial matrixGO0005759hydron [ChEBI:15378]hydronReactomehttp://www.reactome.orgChEBI15378Reactome DB_ID: 293621NADH(2-) [ChEBI:57945]NADH(2-)NADH dianionadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NADHChEBI57945Reactome DB_ID: 1135571pyruvate [ChEBI:15361]pyruvate2-oxopropanoate2-oxopropanoic acid, ion(1-)ChEBI15361Reactome DB_ID: 68076161(S)-lactic acid [ChEBI:422](S)-lactic acidChEBI422Reactome DB_ID: 1135261NAD(1-) [ChEBI:57540]NAD(1-)NAD(+)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD anionChEBI57540PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 6807613UniProt:Q9BYZ2 LDHAL6BLDHAL6BLDHAL6LDHAL6BLDHLPATHWAY Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.TISSUE SPECIFICITY Testis specific.DEVELOPMENTAL STAGE Higher expression level in adult testis as compared to 6-week-old fetal testis.SIMILARITY Belongs to the LDH/MDH superfamily. LDH family.CAUTION It is uncertain whether Met-1 or Met-50 is the initiator.Homo sapiensNCBI Taxonomy9606UniProtQ9BYZ2Chain Coordinates1EQUAL381EQUALGO0004459GO molecular functionReactome Database ID Release 736807609Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6807609Reactome Database ID Release 736807826Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6807826ReactomeR-HSA-68078262Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6807826.219679512Pubmed2009Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHsHolmes, Roger SGoldberg, ErwinComput Biol Chem 33:379-8515870898Pubmed2005Cloning and characterization of a novel intronless lactate dehydrogenase gene in human testisWang, HuiZhou, ZuominLu, LiXu, ZhiyangSha, JiahaoInt. J. Mol. Med. 15:949-53