BioPAX pathway converted from "PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane" in the Reactome database.3.1.3PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membranePI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membraneFormation of a complex with MTMR9 results in a 30-fold increase of phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of MTMR6 and a modest increase in the catalytic activity of MTMR8 (Zou et al. 2009, Zou et al. 2012). Authored: Orlic-Milacic, Marija, 2015-11-13Reviewed: Rush, Mark G, 2017-01-10Edited: Orlic-Milacic, Marija, 2017-01-25Reactome DB_ID: 18062241plasma membraneGO00058861-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]1-phosphatidyl-1D-myo-inositol 3,5-bisphosphatePtsIns-3,5-P21,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',5'-bisphosphate)PtsIns(3,5)P2Reactomehttp://www.reactome.orgChEBI16851Reactome DB_ID: 293561cytosolGO0005829water [ChEBI:15377]waterChEBI15377Reactome DB_ID: 180624011-phosphatidyl-1D-myo-inositol 5-phosphate [ChEBI:16500]1-phosphatidyl-1D-myo-inositol 5-phosphatePI5PChEBI16500Reactome DB_ID: 293721phosphate(3-) [ChEBI:18367]phosphate(3-)ChEBI18367PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 6809318MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGO0052629GO molecular functionReactome Database ID Release 706809317Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6809317Reactome Database ID Release 706809320Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6809320ReactomeR-HSA-68093201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6809320.122647598Pubmed2012Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8Zou, JZhang, ChunfenMarjanovic, JasnaKisseleva, Marina VMajerus, PWWilson, Monita PProc. Natl. Acad. Sci. U.S.A. 109:9539-4419038970Pubmed2009MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosisZou, JChang, Shao-ChunMarjanovic, JasnaMajerus, PWJ. Biol. Chem. 284:2064-71