BioPAX pathway converted from "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+" in the Reactome database.1.2.1.121,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+The reversible reduction of 1,3-bisphosphoglycerate to form glyceraldehyde-3-phosphate is catalyzed by cytosolic glyceraldehyde-3-phosphate dehydrogenase tetramer.<p>There are multiple human glyceraldehyde 3-phosphate dehydrogenase-like pseudogenes, but only one glyceraldehyde 3-phosphate dehydrogenase gene expressed in somatic tissue (Benham and Povey 1989). Consistent with this conclusion, the homogeneous enzymes purified from various human tissues had indistinguishable physical and immunochemical properties (Heinz and Freimuller 1982), and studies of human erythrocytes of various ages suggested that variant forms of the enzyme arise as a result of post-translational modifications (Edwards et al. 1976). There is, however, an authentic second isoform of glyceraldehyde 3-phosphate dehydrogenase whose expression is confined to spermatogenic cells of the testis (Welch et al. 2000).Reviewed: Harris, RA, 2008-09-10 18:47:12Reactome DB_ID: 298001cytosolGO00058293-phosphonato-D-glyceroyl phosphate(4-) [ChEBI:57604]3-phosphonato-D-glyceroyl phosphate(4-)(2R)-2-hydroxy-1-oxopropane-1,3-diyl bis(phosphate)3-phosphonato-D-glyceroyl phosphate tetraanion(2R)-3-phospho-glyceroyl phosphateReactomehttp://www.reactome.orgChEBI57604Reactome DB_ID: 734731NADH(2-) [ChEBI:57945]NADH(2-)NADH dianionadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NADHChEBI57945Reactome DB_ID: 701061hydron [ChEBI:15378]hydronChEBI15378Reactome DB_ID: 295781D-glyceraldehyde 3-phosphate(2-) [ChEBI:59776]D-glyceraldehyde 3-phosphate(2-)D-glyceraldehyde 3-phosphate(2R)-2-hydroxy-3-oxopropyl phosphateD-glyceraldehyde 3-phosphate dianionChEBI59776Reactome DB_ID: 293601NAD(1-) [ChEBI:57540]NAD(1-)NAD(+)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD anionChEBI57540Reactome DB_ID: 293721hydrogenphosphate [ChEBI:43474]hydrogenphosphate[PO3(OH)](2-)HYDROGENPHOSPHATE IONhydrogen phosphate[P(OH)O3](2-)HPO4(2-)phosphateINORGANIC PHOSPHATE GROUPChEBI43474PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 372871GAPDH tetramers [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGO0004365GO molecular functionReactome Database ID Release 7570448Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70448Reactome Database ID Release 7570482Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70482ReactomeR-HSA-704823Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-70482.310714828Pubmed2000Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells.Welch, JEBrown, PLO'Brien, DAMagyar, PLBunch, DOMori, CEddy, EMJ Androl 21:328-387144574Pubmed1983Glyceraldehyde-3-phosphate dehydrogenase from human tissues.Heinz, FFreimüller, BMethods Enzymol 89:301-53170585Pubmed1988Isolation and complete sequence of a functional human glyceraldehyde-3-phosphate dehydrogenase geneErcolani, LFlorence, BDenaro, MAlexander, MJ Biol Chem 263:15335-41183598Pubmed1976Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals.Edwards, YHClark, PHarris, HAnn Hum Genet 40:67-77