BioPAX pathway converted from "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" in the Reactome database.

1.11.1.9

2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Cytosolic glutathione peroxidase (GPX1) tetramer catalyzes the reaction of reduced glutathione and hydrogen peroxide to form reduced glutathione and water (Chu et al. 1993).

Authored: Vastrik, I, 2005-04-29 06:26:51Edited: Vastrik, I, 2005-04-29 06:26:51Edited: D'Eustachio, P, 2006-03-15 17:27:26

Reactome DB_ID: 29408

cytosolGO0005829

hydrogen peroxide [ChEBI:16240]

hydrogen peroxide

Reactomehttp://www.reactome.orgChEBI16240

Reactome DB_ID: 29450

glutathione [ChEBI:16856]

glutathione

ChEBI16856

Reactome DB_ID: 29356

water [ChEBI:15377]

water

ChEBI15377

Reactome DB_ID: 111745

glutathione disulfide [ChEBI:17858]

glutathione disulfide

ChEBI17858PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Reactome DB_ID: 71674

GPX1 tetramer [cytosol]

GPX1 tetramer

glutathione peroxidase tetramer

Reactome DB_ID: 71673

UniProt:P07203 GPX1

GPX1

GPX1FUNCTION Protects the hemoglobin in erythrocytes from oxidative breakdown.SUBUNIT Homotetramer. Interacts with MIEN1.PTM During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine.SIMILARITY Belongs to the glutathione peroxidase family.

Homo sapiens

NCBI Taxonomy9606UniProtP07203

L-selenocysteine residue at 49

EQUAL

L-selenocysteine residue [MOD:00031]

Chain Coordinates

EQUAL

203

EQUAL

Reactome Database ID Release 7171674Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71674ReactomeR-HSA-71674

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71674.1GO0004602

GO molecular function

Reactome Database ID Release 7171675Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71675Reactome Database ID Release 7171676Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=71676ReactomeR-HSA-71676

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-71676.23457020Pubmed1986Glutathione peroxidase protein. Absence in selenium deficiency states and correlation with enzymatic activityTakahashi, KenjiNewburger, P ECohen, H JJ. Clin. Invest. 77:1402-420070187Pubmed2010Irreversible inactivation of glutathione peroxidase 1 and reversible inactivation of peroxiredoxin II by H2O2 in red blood cellsCho, Chun-SeokLee, SukmookLee, Geun TaekWoo, Hyun AeChoi, Eui-JuRhee, Sue GooAntioxid. Redox Signal. 12:1235-468428933Pubmed1993Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GIChu, FFDoroshow, JHEsworthy, RSJ Biol Chem 268:2571-6807573Pubmed1975Purification and properties of human erythrocyte glutathione peroxidaseAwasthi, Y CBeutler, ErnestSrivastava, S KJ. Biol. Chem. 250:5144-9