BioPAX pathway converted from "The Ligand:GPCR:Gq complex dissociates" in the Reactome database.The Ligand:GPCR:Gq complex dissociatesThe Ligand:GPCR:Gq complex dissociatesThe classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (q) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).Authored: Jupe, S, 2010-05-18Reviewed: D'Eustachio, P, 2010-05-21Edited: Jupe, S, 2010-05-26Reactome DB_ID: 7494471plasma membraneGO0005886Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane]Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active)Reactome DB_ID: 1145541Heterotrimeric G-protein Gq (active) [plasma membrane]Heterotrimeric G-protein Gq (active)Reactome DB_ID: 1145341G-protein alpha (q/11): GTP [plasma membrane]G-protein alpha (q/11): GTPReactome DB_ID: 294381cytosolGO0005829GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateReactomehttp://www.reactome.orgChEBI15996Converted from EntitySet in ReactomeReactome DB_ID: 3748481G-protein alpha (q/11) [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGNAQ [plasma membrane]GNA14 [plasma membrane]GNA11 [plasma membrane]GNA15 [plasma membrane]Homo sapiensNCBI Taxonomy9606UniProtP50148UniProtO95837UniProtP29992UniProtP30679Reactome Database ID Release 75114534Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114534ReactomeR-HSA-1145342Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114534.2Reactome DB_ID: 1674341G-protein beta-gamma complex [plasma membrane]G-protein beta-gamma complexConverted from EntitySet in ReactomeReactome DB_ID: 68144131G-protein beta subunit [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGNB1 [cytosol]UniProtP62873Converted from EntitySet in ReactomeReactome DB_ID: 1674421G-protein gamma subunit [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGNG2 [plasma membrane]UniProtP59768Reactome Database ID Release 75167434Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=167434ReactomeR-HSA-1674343Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-167434.3Reactome Database ID Release 75114554Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=114554ReactomeR-HSA-1145541Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-114554.1Converted from EntitySet in ReactomeReactome DB_ID: 3801101photoreceptor disc membraneGO0097381Ligand:GPCR complexes that activate Gq/11 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome Database ID Release 75749447Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=749447ReactomeR-HSA-7494471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-749447.1Converted from EntitySet in ReactomeReactome DB_ID: 7914931GPCRs that activate Gq/11 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityGPR143 [plasma membrane]HTR2C [plasma membrane]P2RY6 [plasma membrane]LPAR4 [plasma membrane]NPFFR2 [plasma membrane]TRHR [plasma membrane]GPR132 [plasma membrane]LPAR1 [plasma membrane]P2RY10 [plasma membrane]HCRTR1 [plasma membrane]FFAR2 [plasma membrane]GPR4 [plasma membrane]KISS1R [plasma membrane]MLNR [plasma membrane]ADRA1D [plasma membrane]CHRM1 [plasma membrane]HRH1 [plasma membrane]LTB4R2 [plasma membrane]TACR3 [plasma membrane]BDKRB1 [plasma membrane]AVPR1A [plasma membrane]UTS2R [plasma membrane]CYSLTR2 [plasma membrane]GRM1 [plasma membrane]GRPR [plasma membrane]LPAR3 [plasma membrane]TACR2 [plasma membrane]PTGFR [plasma membrane]OXTR [plasma membrane]F2R(27-425) [plasma membrane]HCRTR2 [plasma membrane]PTAFR [plasma membrane]ADRA1B [plasma membrane]NPFFR1 [plasma membrane]PTGER1 [plasma membrane]GPR68 [plasma membrane]ADRA1A [plasma membrane]NMUR1 [plasma membrane]LPAR5 [plasma membrane]P2RY2 [plasma membrane]LPAR6 [plasma membrane]CHRM3 [plasma membrane]XCR1 [plasma membrane]NTSR1 [plasma membrane]FFAR4 [plasma membrane]GPRC6A [plasma membrane]EDNRB [plasma membrane]CASR [plasma membrane]MCHR1 [plasma membrane]EDNRA [plasma membrane]F2RL2(22-374) [plasma membrane]GNRHR [plasma membrane]CYSLTR1 [plasma membrane]NPSR1 [plasma membrane]HTR2B [plasma membrane]QRFPR [plasma membrane]MCHR2 [plasma membrane]NMBR [plasma membrane]GPR39 [plasma membrane]OPN4 [photoreceptor disc membrane]LPAR2 [plasma membrane]GRM5 [plasma membrane]CHRM5 [plasma membrane]CCKBR [plasma membrane]GPR17 [plasma membrane]HTR2A [plasma membrane]F2RL3(18-385) [plasma membrane]LTB4R [plasma membrane]AGTR1 [plasma membrane]NMUR2 [plasma membrane]PROKR2 [plasma membrane]FPR2 [plasma membrane]P2RY11 [plasma membrane]NTSR2 [plasma membrane]PROKR1 [plasma membrane]GPR65 [plasma membrane]FFAR3 [plasma membrane]CCKAR [plasma membrane]GNRHR2 [plasma membrane]AVPR1B [plasma membrane]GHSR [plasma membrane]TACR1 [plasma membrane]BDKRB2 [plasma membrane]TBXA2R [plasma membrane]P2RY1 [plasma membrane]FFAR1 [plasma membrane]F2RL1(37-397) [plasma membrane]UniProtP51810UniProtP28335UniProtQ15077UniProtQ99677UniProtQ9Y5X5UniProtP34981UniProtQ9UNW8UniProtQ92633UniProtO00398UniProtO43613UniProtO15552UniProtP46093UniProtQ969F8UniProtO43193UniProtP25100UniProtP11229UniProtP35367UniProtQ9NPC1UniProtP29371UniProtP46663UniProtP37288UniProtQ9UKP6UniProtQ9NS75UniProtQ13255UniProtP30550UniProtQ9UBY5UniProtP21452UniProtP43088UniProtP30559UniProtP25116UniProtO43614UniProtP25105UniProtP35368UniProtQ9GZQ6UniProtP34995UniProtQ15743UniProtP35348UniProtQ9HB89UniProtQ9H1C0UniProtP41231UniProtP43657UniProtP20309UniProtP46094UniProtP30989UniProtQ5NUL3UniProtQ5T6X5UniProtP24530UniProtP41180UniProtQ99705UniProtP25101UniProtO00254UniProtP30968UniProtQ9Y271UniProtQ6W5P4UniProtP41595UniProtQ96P65UniProtQ969V1UniProtP28336UniProtO43194UniProtQ9UHM6UniProtQ9HBW0UniProtP41594UniProtP08912UniProtP32239UniProtQ13304UniProtP28223UniProtQ96RI0UniProtQ15722UniProtP30556UniProtQ9GZQ4UniProtQ8NFJ6UniProtP25090UniProtQ96G91UniProtO95665UniProtQ8TCW9UniProtQ8IYL9UniProtO14843UniProtP32238UniProtQ96P88UniProtP47901UniProtQ92847UniProtP25103UniProtP30411UniProtP21731UniProtP47900UniProtO14842UniProtP55085Converted from EntitySet in ReactomeReactome DB_ID: 7914921extracellular regionGO0005576Ligands of GPCRs that activate Gq/11 [extracellular region]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityNMB(47-56) [extracellular region]LTC4 [extracellular region]Ca2+ [extracellular region]AGT(34-41) [extracellular region]SAA1(19-122) [extracellular region]Zn2+ [extracellular region]GNRH2(24-33) [extracellular region]ADP [extracellular region]Pentadecanoic acid [extracellular region]DTTA [extracellular region]L-Orn [extracellular region]HCOOH [extracellular region]PAF [extracellular region]TAC1(58-68) [extracellular region]UDP [extracellular region]11,14,17-eicosatrienoic acid [extracellular region]GRP(24-50) [extracellular region]EDN1 [extracellular region]EDN3(97-117) [extracellular region]NTS(151-163) [extracellular region]DPA [extracellular region]AVP(20-28) [extracellular region]ALA [extracellular region]CCK [extracellular region]Pmoa [extracellular region]NMS [extracellular region]AcCho [extracellular region]TXA2 [extracellular region]L-Dopa [extracellular region]PGE2 [extracellular region]OXT(20-28) [extracellular region]PGF2a [extracellular region]LTD4 [extracellular region]LPA [extracellular region]ADR [extracellular region]OLEA [extracellular region]TAC3 [extracellular region]TRH(84-86) [extracellular region]XCL2 [extracellular region]O-octanoyl-L-serine-GHRL-1(24-50) [extracellular region]TRH(152-154) [extracellular region]QRFP [extracellular region]ELDA [extracellular region]STEA [extracellular region]Bradykinin [extracellular region]O-octanoyl-L-serine-GHRL-1(24-51) [extracellular region]ATP [extracellular region]EDN2 [extracellular region]KISS1(68-121) [extracellular region]NPFF(69-76) [extracellular region]TRH(114-116) [extracellular region]UTS2 [extracellular region]MYSA [extracellular region]CH3COO- [extracellular region]LTB4 [extracellular region]PALM [extracellular region]DecS-GHRL-1(24-50) [extracellular region]TRH(135-137) [extracellular region]XCL1 [extracellular region]H+ [extracellular region]PROK1 [extracellular region]LXA4 [extracellular region]NPS [extracellular region]Valerate [extracellular region]TRH(186-188) [extracellular region]HXA [extracellular region]L-Lys [extracellular region]UTS2B [extracellular region]L-Arg [extracellular region]PROK2 [extracellular region]ANXA1 [extracellular region]TAC1(98-107) [extracellular region]EtCOO- or C2H5COO- [extracellular region]5HT [extracellular region]GNRH1(24-33) [extracellular region]DecS-GHRL-1(24-51) [extracellular region]NAd [extracellular region]EPA [extracellular region]CCL23-2 [extracellular region]PMCH(147-165) [extracellular region]GAST(76-92) [extracellular region]DHA [extracellular region]RGZ [extracellular region]MLN(26-47) [extracellular region]NMU [extracellular region]HCRT(34-66) [extracellular region]GLA [extracellular region]L-Glu [extracellular region]HCRT(70-97) [extracellular region]Photon [extracellular region]BUT [extracellular region]DDCX [extracellular region]APP(672-713) [extracellular region]Hist [extracellular region]MT-RNR2 [extracellular region]8,11,14-Eicosatrienoic acid [extracellular region]TRH(227-229) [extracellular region]LTE4 [extracellular region]GCG(53-81) [extracellular region]UniProtP08949ChEBI16978ChEBI29108UniProtP01019UniProtP0DJI8ChEBI29105UniProtO43555ChEBI456216ChEBI42504ChEBI53487ChEBI15729ChEBI30751ChEBI52450UniProtP20366ChEBI17659ChEBI53460UniProtP07492UniProtP05305UniProtP14138UniProtP30990ChEBI53488UniProtP01185ChEBI27432UniProtP06307ChEBI28716UniProtQ5H8A3ChEBI15355ChEBI15627ChEBI15765ChEBI15551UniProtP01178ChEBI15553ChEBI28666ChEBI52288ChEBI28918ChEBI16196UniProtQ9UHF0UniProtP20396UniProtQ9UBD3UniProtQ9UBU3-1UniProtP83859ChEBI27997ChEBI9254UniProtP01042ChEBI30616UniProtP20800UniProtQ15726UniProtO15130UniProtO95399ChEBI28875ChEBI15366ChEBI15647ChEBI15756UniProtP47992ChEBI15378UniProtP58294ChEBI6498UniProtP0C0P6ChEBI31011ChEBI17120ChEBI32551UniProtQ765I0ChEBI32682UniProtQ9HC23UniProtP04083ChEBI30768ChEBI28790UniProtP01148ChEBI18357ChEBI28364UniProtP55773-2UniProtP20382UniProtP01350ChEBI28125ChEBI50122UniProtP12872UniProtP48645UniProtO43612ChEBI28661ChEBI29985ChEBI30212ChEBI30772ChEBI30805UniProtP05067ChEBI18295UniProtQ8IVG9ChEBI53486ChEBI15650UniProtP01275Reactome DB_ID: 1145341Reactome DB_ID: 1674341Reactome Database ID Release 75749452Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=749452ReactomeR-HSA-7494522Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-749452.28736705Pubmed1996GTP binding to Gs does not promote subunit dissociationBasi, NSOkuya, SRebois, RVCell Signal 8:209-1518577758Pubmed2008Dissociation of heterotrimeric g proteins in cellsLambert, NASci Signal 1:re5