BioPAX pathway converted from "IL34 dimer binds PTPRZ1" in the Reactome database.IL34 dimer binds PTPRZ1

IL34 dimer binds PTPRZ1

Interleukin-34 (IL34) signals via the Colony-stimulating factor-1 receptor (CSF1R). It can also bind Receptor-type protein-tyrosine phosphatase zeta (PTPRZ1), a cell surface chondroitin sulfate (CS) proteoglycan. PTPRZ1 is primarily expressed on neural progenitor and glial cells. IL34 selectively bound PTPRZ1 in CSF1R-deficient U251 human glioblastoma cell lysates, inhibiting proliferation, clonogenicity and motility, and promoting an increase in tyrosine phosphorylation of focal adhesion kinase 1 (PTK2) and paxillin (PXN) (Nandii et al. 2013).

Authored: Jupe, Steve, 2017-03-13Reviewed: Meldal, Birgit, 2017-11-03Edited: Jupe, Steve, 2017-11-03

Reactome DB_ID: 374561

plasma membraneGO0005886

UniProt:P23471 PTPRZ1

PTPRZ1

PTPRZ1PTPRZ2HTPZP2PTPRZPTPZFUNCTION Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades (By similarity).SUBUNIT The carbonic-anhydrase like domain interacts with CNTN1 (contactin) (PubMed:20133774). Interacts with PTN (PubMed:16814777). Interaction with PTN promotes formation of homooligomers; oligomerization impairs phosphatase activity (By similarity). Interacts (via chondroitin sulfate chains) with MDK (via C-terminal); this interaction is inhibited by PTN; this interaction promotes neuronal migration (By similarity).TISSUE SPECIFICITY Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.SIMILARITY Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.CAUTION Was termed (PubMed:8387522 and PubMed:2170109) RPTPase beta.CAUTION The human genome was initially thought to contain 2 genes for PTPRZ: PTPRZ1 (on chr 7) and PTPRZ2 (on chr 1). However, PTPRZ2 probably does not exist and corresponds to PTPRZ1.

Reactomehttp://www.reactome.orgHomo sapiens

NCBI Taxonomy9606UniProtP23471

Chain Coordinates

EQUAL

2315

EQUAL

Reactome DB_ID: 448628

extracellular regionGO0005576IL34 dimer [extracellular region]

IL34 dimer

Reactome DB_ID: 448636

UniProt:Q6ZMJ4 IL34

IL34

IL34C16orf77FUNCTION Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.SUBUNIT Homodimer. Interacts with CSF1R.TISSUE SPECIFICITY Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.SIMILARITY Belongs to the IL-34 family.

UniProtQ6ZMJ4

EQUAL

242

EQUAL

Reactome Database ID Release 70448628Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=448628ReactomeR-HSA-448628

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-448628.1

Reactome DB_ID: 8981669

IL34 dimer:PTPRZ1 [plasma membrane]

IL34 dimer:PTPRZ1

Reactome DB_ID: 374561

EQUAL

2315

EQUAL

Reactome DB_ID: 448628

Reactome Database ID Release 708981669Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8981669ReactomeR-HSA-8981669

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8981669.1Reactome Database ID Release 708981657Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8981657ReactomeR-HSA-8981657

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8981657.123744080Pubmed2013Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34Nandi, SayanCioce, MarioYeung, Yee-GuideNieves, EdwardTesfa, LydiaLin, HaishanHsu, Amy WHalenbeck, RobertCheng, Hui-YongGokhan, SolenMehler, Mark FStanley, E RichardJ. Biol. Chem. 288:21972-86