BioPAX pathway converted from "JAK1 binds IL20RA" in the Reactome database.JAK1 binds IL20RAJAK1 binds IL20RATyrosine protein kinase JAK1 (JAK1) binds Interleukin-20 receptor subunit alpha (IL20RA). JAK1 coimmunoprecipitates with several class II receptor complexes including Interferon gamma receptor 1 (IFNGR1), Interferon alpha/beta receptor 2 (IFNAR2), Interferon lambda receptor 1 (IFNLR1), Interleukin-10 receptor subunit alpha (IL10RA), Interleukin-22 receptor subunit alpha 1 (IL22RA1) and Interleukin-20 receptor subunit alpha (IL20RA), leading to the suggestion that Class II receptors may have a common sequence motif for JAK recognition (Ferrao et al. 2016). This is a black box event because JAK1 binding to IL20RA is inferred from binding to related receptors and subsequent JAK/STAT signaling events (Ferrao et al 2016, Hann et al. 2006, Murakami et al. 1991). Authored: Duenas, Corina, 2017-03-16Reviewed: Datta, Sandip K, 2017-11-15Edited: Jupe, Steve, 2017-11-07Reactome DB_ID: 4518981cytosolGO0005829UniProt:P23458 JAK1JAK1JAK1BJAK1AJAK1FUNCTION Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).SUBUNIT Interacts with IL31RA (PubMed:15194700). Interacts with IFNAR2 (PubMed:7759950). Interacts with IFNGR1 (PubMed:7615558). Interacts with JAKMIP1 (PubMed:15277531). Interacts with SHB (PubMed:12200137). Interacts (via N-terminus) with IL2RB and IL10RA (via its cytoplasmic domain) (PubMed:12133952). Interacts with FER (By similarity).TISSUE SPECIFICITY Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.DOMAIN Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.DOMAIN The FERM domain mediates interaction with JAKMIP1.PTM Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).PTM Ubiquitinated by RNF125; leading to its degradation by the proteasome.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtP23458Chain Coordinates1EQUAL1154EQUALReactome DB_ID: 4487131plasma membraneGO0005886UniProt:Q9UHF4 IL20RAIL20RAIL20RAUNQ681/PRO1315FUNCTION The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.SUBUNIT Heterodimer with IL20RB and heterodimer with IL10RB.TISSUE SPECIFICITY Widely expressed with highest levels in skin and testis and high levels in brain. Highly expressed in psoriatic skin.SIMILARITY Belongs to the type II cytokine receptor family.UniProtQ9UHF430EQUAL553EQUALReactome DB_ID: 89870711IL20RA:JAK1 [plasma membrane]IL20RA:JAK1Reactome DB_ID: 45189811EQUAL1154EQUALReactome DB_ID: 448713130EQUAL553EQUALReactome Database ID Release 758987071Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8987071ReactomeR-HSA-89870711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8987071.1Reactome Database ID Release 758987039Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8987039ReactomeR-HSA-89870391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8987039.116750817Pubmed2006Jaks and cytokine receptors--an intimate relationshipHaan, ClaudeKreis, StephanieMargue, ChristianeBehrmann, IrisBiochem. Pharmacol. 72:1538-461662392Pubmed1991Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor familyMurakami, MNarazaki, MHibi, MYawata, HYasukawa, KHamaguchi, MTaga, TKishimoto, TProc Natl Acad Sci U S A 88:11349-5327133025Pubmed2016The Structural Basis for Class II Cytokine Receptor Recognition by JAK1Ferrao, RyanWallweber, Heidi J AHo, HoangdungTam, ChristineFranke, YvonneQuinn, JohnLupardus, Patrick JStructure 24:897-905