BioPAX pathway converted from "JAK1 binds IFNLR1" in the Reactome database.JAK1 binds IFNLR1JAK1 binds IFNLR1JAK1 binds IL28RATyrosine protein kinase JAK1 (JAK1) binds Interferon lambda receptor 1 (IFNLR1).<br>The Box1 of IFNLR1 binds to the F2 subdomain of the JAK1 FERM, in a cleft formed by helices F2 alpha2, F2 alpha3, and F2 alpha4 (Ferrao et al. 2017).Authored: Duenas, Corina, 2017-03-16Reviewed: Datta, Sandip K, 2017-11-15Edited: Jupe, Steve, 2017-11-07Reactome DB_ID: 4518981cytosolGO0005829UniProt:P23458 JAK1JAK1JAK1BJAK1AJAK1FUNCTION Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529) as well as interleukin (IL)-10 receptor (PubMed:12133952).SUBUNIT Interacts with IL31RA (PubMed:15194700). Interacts with IFNAR2 (PubMed:7759950). Interacts with IFNGR1 (PubMed:7615558). Interacts with JAKMIP1 (PubMed:15277531). Interacts with SHB (PubMed:12200137). Interacts (via N-terminus) with IL2RB and IL10RA (via its cytoplasmic domain) (PubMed:12133952). Interacts with FER (By similarity).TISSUE SPECIFICITY Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.DOMAIN Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1.DOMAIN The FERM domain mediates interaction with JAKMIP1.PTM Autophosphorylated (PubMed:7615558). Phosphorylated on tyrosine residues in response to interferon gamma signaling (PubMed:7615558). Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling (PubMed:11909529).PTM Ubiquitinated by RNF125; leading to its degradation by the proteasome.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtP23458Chain Coordinates1EQUAL1154EQUALReactome DB_ID: 4485921plasma membraneGO0005886UniProt:Q8IU57 IFNLR1IFNLR1IL28RALICR2IFNLR1FUNCTION The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.SUBUNIT Heterodimer with IL10RB.TISSUE SPECIFICITY Widely expressed.SIMILARITY Belongs to the type II cytokine receptor family.UniProtQ8IU5721EQUAL520EQUALReactome DB_ID: 89872161IFNLR1:JAK1 [plasma membrane]IFNLR1:JAK1Reactome DB_ID: 45189811EQUAL1154EQUALReactome DB_ID: 448592121EQUAL520EQUALReactome Database ID Release 758987216Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8987216ReactomeR-HSA-89872161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8987216.1Reactome Database ID Release 758987120Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8987120ReactomeR-HSA-89871201Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8987120.128458652Pubmed2017The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor InteractionsFerrao, RyanLupardus, Patrick JFront Endocrinol (Lausanne) 8:71