BioPAX pathway converted from "Estrogen stimulates dimerization of plasma membrane estrogen receptors" in the Reactome database.Estrogen stimulates dimerization of plasma membrane estrogen receptorsEstrogen stimulates dimerization of plasma membrane estrogen receptorsPlasma membrane-localized estrogen receptors signal as dimers, and dimerization is promoted by stimulation with estrogen (Razandi et al, 2004). Because palmitoylation of cytoplasmic estrogen receptors occurs on the monomeric form, estrogen (ESTG) stimulation restricts both the amount of palmitoylated receptor and its localization at the plasma membrane (Acconcia et al, 2005; Razandi et al, 2010; Pedram et al, 2012). This may serve to limit the extent of the rapid response to estrogen stimulation.Authored: Rothfels, Karen, 2017-09-29Reviewed: Levin, Ellis R, 2019-02-19Reviewed: Acconcia, Filippo, 2019-04-24Reviewed: Marino, Maria, 2019-04-24Reactome DB_ID: 3741462extracellular regionGO0005576estrogen [ChEBI:50114]estrogenReactomehttp://www.reactome.orgChEBI50114Converted from EntitySet in ReactomeReactome DB_ID: 96377892plasma membraneGO0005886Me-PalmS-ESRs [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityMe260-PalmS-ESR1 [plasma membrane]Homo sapiensNCBI Taxonomy9606UniProtP03372Reactome DB_ID: 96346121ESTG:Me-PalmS-ESR dimers [plasma membrane]ESTG:Me-PalmS-ESR dimersReactome DB_ID: 3741462Converted from EntitySet in ReactomeReactome DB_ID: 96377892Reactome Database ID Release 759634612Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9634612ReactomeR-HSA-96346121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9634612.1Reactome Database ID Release 759021170Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9021170ReactomeR-HSA-90211702Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9021170.220439495Pubmed2010Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membraneRazandi, MahnazPedram, AliLevin, Ellis RMol. Cell. Biol. 30:3249-6115496458Pubmed2005Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiolAcconcia, FilippoAscenzi, PaoloBocedi, AlessioSpisni, EnzoTomasi, VittorioTrentalance, AnnaVisca, PaoloMarino, MariaMol. Biol. Cell 16:231-715231873Pubmed2004Plasma membrane estrogen receptors exist and functions as dimersRazandi, MahnazPedram, AliMerchenthaler, IstvanGreene, Geoffrey LLevin, Ellis RMol. Endocrinol. 18:2854-6522031296Pubmed2012DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptorsPedram, AliRazandi, MahnazDeschenes, Robert JLevin, Ellis RMol. Biol. Cell 23:188-99