BioPAX pathway converted from "Estrogen stimulates dimerization of plasma membrane estrogen receptors" in the Reactome database.Estrogen stimulates dimerization of plasma membrane estrogen receptorsEstrogen stimulates dimerization of plasma membrane estrogen receptorsPlasma membrane-localized estrogen receptors signal as dimers, and dimerization is promoted by stimulation with estrogen (Razandi et al, 2004). Because palmitoylation of cytoplasmic estrogen receptors occurs on the monomeric form, estrogen (ESTG) stimulation restricts both the amount of palmitoylated receptor and its localization at the plasma membrane (Acconcia et al, 2005; Razandi et al, 2010; Pedram et al, 2012). This may serve to limit the extent of the rapid response to estrogen stimulation.Authored: Rothfels, Karen, 2017-09-29Reviewed: Levin, Ellis R, 2019-02-19Reviewed: Acconcia, Filippo, 2019-04-24Reviewed: Marino, Maria, 2019-04-24Converted from EntitySet in ReactomeReactome DB_ID: 96377892plasma membraneGO0005886Me-PalmS-ESRs [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityMe260-PalmS-ESR1 [plasma membrane]Reactomehttp://www.reactome.orgHomo sapiensNCBI Taxonomy9606UniProtP03372Reactome DB_ID: 3741462extracellular regionGO0005576estrogen [ChEBI:50114]estrogenChEBI50114Reactome DB_ID: 96346121ESTG:Me-PalmS-ESR dimers [plasma membrane]ESTG:Me-PalmS-ESR dimersConverted from EntitySet in ReactomeReactome DB_ID: 96377892Reactome DB_ID: 3741462Reactome Database ID Release 729634612Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9634612ReactomeR-HSA-96346121Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9634612.1Reactome Database ID Release 729021170Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9021170ReactomeR-HSA-90211702Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9021170.215231873Pubmed2004Plasma membrane estrogen receptors exist and functions as dimersRazandi, MahnazPedram, AliMerchenthaler, IstvanGreene, Geoffrey LLevin, Ellis RMol. Endocrinol. 18:2854-6515496458Pubmed2005Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiolAcconcia, FilippoAscenzi, PaoloBocedi, AlessioSpisni, EnzoTomasi, VittorioTrentalance, AnnaVisca, PaoloMarino, MariaMol. Biol. Cell 16:231-720439495Pubmed2010Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membraneRazandi, MahnazPedram, AliLevin, Ellis RMol. Cell. Biol. 30:3249-6122031296Pubmed2012DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptorsPedram, AliRazandi, MahnazDeschenes, Robert JLevin, Ellis RMol. Biol. Cell 23:188-99