BioPAX pathway converted from "Activated chicken TAK1 dissociates from the activated TLR3 complex" in the Reactome database. Activated chicken TAK1 dissociates from the activated TLR3 complex Activated chicken TAK1 dissociates from the activated TLR3 complex Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leaves the activated TLR4 complex and translocates to the cytosol Authored: Shamovsky, V, 2010-08-04 Reviewed: D'Eustachio, P, 2010-10-15 Edited: Shamovsky, V, 2010-11-05 Reactome DB_ID: 434152 1 endosome membrane GO 0010008 viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2:TAB3 :phospho TAK1 : TAB1 : free pUb chain [endosome membrane] viral dsRNA : TLR3 : TICAM1 : pUb_TRAF6 :TAB2:TAB3 :phospho TAK1 : TAB1 : free pUb chain Reactome DB_ID: 433952 2 ENSEMBL:ENSGALP00000025101 TGF-beta- activated kinase 1 TGF-beta- activated kinase 1 MAP3K7 Reactome http://www.reactome.org Gallus gallus NCBI Taxonomy 9031 ENSEMBL ENSGALP00000025101 O-phospho-L-threonine at unknown position O-phospho-L-threonine [MOD:00047] O-phospho-L-threonine at unknown position Chain Coordinates 1 EQUAL 617 EQUAL Reactome DB_ID: 451962 2 cytosol GO 0005829 free K63_polyubiquitin chain [cytosol] free K63_polyubiquitin chain Reactome DB_ID: 433923 2 ENSEMBL:ENSGALP00000020155 TAB2 TAB2 MAP3K7IP2 (TAB2) ENSEMBL ENSGALP00000020155 1 EQUAL 697 EQUAL Reactome DB_ID: 434102 1 viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 [endosome membrane] viral ds RNA : TLR3 : TICAM1 : pUb-TRAF6 Reactome DB_ID: 433947 1 viral dsRNA : TLR3 : TICAM1 [endosome membrane] viral dsRNA : TLR3 : TICAM1 Reactome DB_ID: 433883 1 viral dsRNA:TLR3 [endosome membrane] viral dsRNA:TLR3 Reactome DB_ID: 433892 2 UniProt:Q0PQ88 Toll-like receptor 3 Toll-like receptor 3 TLR3 SIMILARITY Contains 1 TIR domain. UniProt Q0PQ88 1 EQUAL 1011 EQUAL Reactome DB_ID: 9014378 1 endosome lumen GO 0031904 IBV dsRNA intermediate form [endosome lumen] IBV dsRNA intermediate form Reactome Database ID Release 82 433883 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433883 Reactome R-GGA-433883 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433883.3 Reactome DB_ID: 433979 2 UniProt:A0FKC7 Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta TLR adaptor molecule 1(TRIF) <submittedName> <fullName>Toll/IL-1 recepter (TIR)-domain containing adapter inducing interferon beta</fullName> </submittedName> UniProt A0FKC7 1 EQUAL 735 EQUAL Reactome Database ID Release 82 433947 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=433947 Reactome R-GGA-433947 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-433947.2 Reactome DB_ID: 434011 2 pUb_TRAF6 [endosome membrane] pUb_TRAF6 Reactome DB_ID: 433989 1 K63_polyubiquitin chain [endosome membrane] K63_polyubiquitin chain Reactome DB_ID: 433792 1 UniProt:E1C626 TRAF6 TRAF6 TRAF6 SIMILARITY: Contains 1 MATH domain. UniProt E1C626 Reactome Database ID Release 82 434011 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434011 Reactome R-GGA-434011 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434011.1 Reactome Database ID Release 82 434102 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434102 Reactome R-GGA-434102 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434102.2 Reactome DB_ID: 442975 2 ENSEMBL:ENSGALP00000026205 TAB3 TAB3 MAP3K7IP3 ENSEMBL ENSGALP00000026205 Reactome DB_ID: 434141 2 UniProt:Q5ZJW3 RCJMB04_15c17 RCJMB04_15c17 RCJMB04_15c17 <submittedName> <fullName>Putative uncharacterized protein</fullName> </submittedName> UniProt Q5ZJW3 1 EQUAL 438 EQUAL Reactome Database ID Release 82 434152 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=434152 Reactome R-GGA-434152 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-434152.2 Reactome DB_ID: 921146 1 pUB-TRAF6:TAB2:TAB3:TAB1:free K63-pUb chain:phospho TAK1 [cytosol] pUB-TRAF6:TAB2:TAB3:TAB1:free K63-pUb chain:phospho TAK1 Reactome DB_ID: 451455 2 pUb_TRAF6 [cytosol] pUb_TRAF6 Reactome DB_ID: 434061 1 K63_polyubiquitin chain [cytosol] K63_polyubiquitin chain Reactome DB_ID: 433886 1 Reactome Database ID Release 82 451455 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=451455 Reactome R-GGA-451455 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-451455.1 Reactome DB_ID: 434032 2 1 EQUAL 697 EQUAL Reactome DB_ID: 434061 2 Reactome DB_ID: 433882 2 1 EQUAL 438 EQUAL Reactome DB_ID: 451473 2 O-phospho-L-threonine at unknown position O-phospho-L-threonine at unknown position 1 EQUAL 617 EQUAL Reactome DB_ID: 442867 2 Reactome Database ID Release 82 921146 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=921146 Reactome R-GGA-921146 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-921146.1 Reactome DB_ID: 433947 1 Reactome Database ID Release 82 921145 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=921145 Reactome R-GGA-921145 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-GGA-921145.3 12609980 Pubmed 2003 Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z Zamanian-Daryoush, M Nie, H Silva, AM Williams, BR Li, X J Biol Chem 278:16713-9