BioPAX pathway converted from "FOXO6 binds PLXNA4 gene" in the Reactome database.FOXO6 binds PLXNA4 gene

FOXO6 binds PLXNA4 gene

Based on studies in mice, FOXO6 binds FOXO response elements in the PLXNA4 gene locus, encoding the semaphorin SEMA3A co-receptor PLXNA4. FOXO response elements are found in the promoter and the first intron of the mouse Plxna4 gene (Paap et al. 2016). The first intron of the human PLXNA4 gene contains several predicted FOXO response elements.

Authored: Orlic-Milacic, Marija, 2018-10-11Reviewed: Donlon, Timothy, 2018-10-17Reviewed: Bertaggia, Enrico, 2018-10-26Edited: Orlic-Milacic, Marija, 2018-10-31

Reactome DB_ID: 9614396

nucleoplasmGO0005654

UniProt:A8MYZ6 FOXO6

FOXO6

FOXO6FUNCTION Transcriptional activator.PTM Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.

Reactomehttp://www.reactome.orgHomo sapiens

NCBI Taxonomy9606UniProtA8MYZ6

Chain Coordinates

EQUAL

492

EQUAL

Reactome DB_ID: 9615220

ENSEMBL:ENSG00000221866 PLXNA4PLXNA4BPLXNA4AUNQ2820/PRO34003KIAA1550PLXNA4

ENSEMBLENSG00000221866

Reactome DB_ID: 9615222

FOXO6:PLXNA4 gene [nucleoplasm]

FOXO6:PLXNA4 gene

Reactome DB_ID: 9614396

EQUAL

492

EQUAL

Reactome DB_ID: 9615220

Reactome Database ID Release 759615222Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615222ReactomeR-HSA-9615222

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9615222.1Reactome Database ID Release 759615015Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9615015ReactomeR-HSA-9615015

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9615015.127791111Pubmed2016FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical developmentPaap, Ricardo HOosterbroek, SaskiaWagemans, Cindy M R Jvon Oerthel, LarsSchellevis, Raymond DVastenhouw-van der Linden, Annemarie J AGroot Koerkamp, Marian J AHoekman, Marco F MSmidt, Marten PProc. Natl. Acad. Sci. U.S.A.