BioPAX pathway converted from "Phospho-CREB1 binds the promoter of the CEBPB gene" in the Reactome database. Phospho-CREB1 binds the promoter of the CEBPB gene Phospho-CREB1 binds the promoter of the CEBPB gene CREB1 that is phosphorylated in response to CSF2 (GM-CSF) binds cyclic AMP responsive elements (CREs) in the promoter of the CEBPB gene (inferred from mouse homologs). Transcription of CEBPB is activated during "emergency granulopoiesis" by cytokines produced in response to bacterial infection. Authored: May, Bruce, 2018-08-16 Reviewed: Skokowa, Julia, 2019-03-10 Edited: May, Bruce, 2018-08-16 Reactome DB_ID: 111911 1 nucleoplasm GO 0005654 p-S133-CREB1 homodimer [nucleoplasm] p-S133-CREB1 homodimer phospho-CREB dimer Reactome DB_ID: 111910 2 UniProt:P16220 CREB1 CREB1 CREB1 FUNCTION Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.SUBUNIT Interacts with PPRC1. Binds DNA as a dimer. This dimer is stabilized by magnesium ions. Interacts, through the bZIP domain, with the coactivators TORC1/CRTC1, TORC2/CRTC2 and TORC3/CRTC3. When phosphorylated on Ser-119, binds CREBBP (By similarity). Interacts with CREBL2; regulates CREB1 phosphorylation, stability and transcriptional activity (By similarity). Interacts (phosphorylated form) with TOX3. Interacts with ARRB1. Binds to HIPK2. Interacts with SGK1. Interacts with TSSK4; this interaction facilitates phosphorylation on Ser-119 (PubMed:15964553). Forms a complex with KMT2A and CREBBP (PubMed:23651431).SUBUNIT (Microbial infection) Interacts with hepatitis B virus/HBV protein X.SUBUNIT (Microbial infection) Interacts with HTLV-1 protein Tax.PTM Stimulated by phosphorylation. Phosphorylation of both Ser-119 and Ser-128 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-119 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-119 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-119. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-128. Phosphorylation of Ser-128 blocks CREB-mediated transcription even when Ser-119 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-257 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-119 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli. Phosphorylated by TSSK4 on Ser-119 (PubMed:15964553).PTM Sumoylated with SUMO1. Sumoylation on Lys-290, but not on Lys-271, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.DISEASE A CREB1 mutation has been found in a patient with multiple congenital anomalies consisting of agenesis of the corpus callosum, cerebellar hypoplasia, severe neonatal respiratory distress refractory to surfactant, thymus hypoplasia, and thyroid follicular hypoplasia.SIMILARITY Belongs to the bZIP family. Reactome http://www.reactome.org Homo sapiens NCBI Taxonomy 9606 UniProt P16220 O-phospho-L-serine at 133 133 EQUAL O-phospho-L-serine [MOD:00046] Chain Coordinates 1 EQUAL 341 EQUAL Reactome Database ID Release 81 111911 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=111911 Reactome R-HSA-111911 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-111911.2 Reactome DB_ID: 3858376 1 ENSEMBL:ENSG00000172216 CEBPB CEBPB PP9092 TCF5 ENSEMBL ENSG00000172216 Reactome DB_ID: 9617243 1 CEBPB gene:p-S133-CREB1 dimer [nucleoplasm] CEBPB gene:p-S133-CREB1 dimer Reactome DB_ID: 111911 1 Reactome DB_ID: 3858376 1 Reactome Database ID Release 81 9617243 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9617243 Reactome R-HSA-9617243 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9617243.1 Reactome Database ID Release 81 9617217 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9617217 Reactome R-HSA-9617217 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-9617217.1