BioPAX pathway converted from "Na+/H+ exchanger transport (at cell membrane)" in the Reactome database.Na+/H+ exchanger transport (at cell membrane)

Na+/H+ exchanger transport (at cell membrane)

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 74113

extracellular regionGO0005576

sodium(1+) [ChEBI:29101]

sodium(1+)

Reactomehttp://www.reactome.orgChEBI29101

Reactome DB_ID: 70106

cytosolGO0005829

hydron [ChEBI:15378]

hydron

ChEBI15378

Reactome DB_ID: 351626

Reactome DB_ID: 83910

PHYSIOL-LEFT-TO-RIGHT

ACTIVATION

Converted from EntitySet in Reactome

Reactome DB_ID: 9740689

plasma membraneGO0005886

SLC9A1-5 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySlc9a1 [plasma membrane]Slc9a4 [plasma membrane]Slc9a5 [plasma membrane]Slc9a2 [plasma membrane]Slc9a3 [plasma membrane]

Mus musculus

NCBI Taxonomy10090UniProtQ61165UniProtQ8BUE1UniProtB2RXE2UniProtQ3ZAS0UniProtG3X939GO0015385

GO molecular function

Reactome Database ID Release 759740690Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9740690Reactome Database ID Release 759740692Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9740692ReactomeR-MMU-425994

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-425994.1NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.

7631746Pubmed1995Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Brant, SRYun, CHDonowitz, MTse, CMAm J Physiol 269:C198-2062536298Pubmed1989Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporterSardet, CFranchi, APouysségur, JacquesCell 56:271-8010444453Pubmed1999Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2Malakooti, JDahdal, RYSchmidt, LLayden, TJDudeja, PKRamaswamy, KAm J Physiol 277:G383-909933641Pubmed1999Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brainBaird, NROrlowski, JSzabó, EZZaun, HCSchultheis, PJMenon, AGShull, GEJ Biol Chem 274:4377-82inferred by electronic annotationIEAGOIEA