BioPAX pathway converted from "CHD1L is recruited to GG-NER site" in the Reactome database.CHD1L is recruited to GG-NER site

CHD1L is recruited to GG-NER site

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 9789920

nucleoplasmGO0005654

UniProt:Q9CXF7Chd1l

Reactomehttp://www.reactome.orgMus musculus

NCBI Taxonomy10090UniProtQ9CXF7

Chain Coordinates

EQUAL

897

EQUAL

Reactome DB_ID: 9790037

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm]

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2

Reactome DB_ID: 9789914

UniProt:Q64267Xpa

UniProtQ64267

EQUAL

273

EQUAL

Reactome DB_ID: 9790033

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm]

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2

Reactome DB_ID: 9785744

PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]

PAR-PARP1,PAR-PARP2 dimers

Converted from EntitySet in Reactome

Reactome DB_ID: 9785742

PAR-PARP1,PAR-PARP2 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityParp1 [nucleoplasm]

UniProtP11103Reactome Database ID Release 759785744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9785744ReactomeR-MMU-5651709

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5651709.1

Reactome DB_ID: 9790031

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB [nucleoplasm]

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB

Reactome DB_ID: 9790029

Ub:XPC:RAD23:CETN2 [nucleoplasm]

Ub:XPC:RAD23:CETN2

Reactome DB_ID: 9778964

UniProt:Q9R1K9Cetn2

UniProtQ9R1K9

EQUAL

172

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 9790022

RAD23 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityRad23b [nucleoplasm]

UniProtP54728

Reactome DB_ID: 9790027

Ub:XPC [nucleoplasm]

Ub:XPC

Converted from EntitySet in Reactome

Reactome DB_ID: 9707835

Ub [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityUbb [nucleoplasm]Ubiquitin (Ubb 3) [nucleoplasm]Ubiquitin (Ubb 4) [nucleoplasm]Ubiquitin (Pps27a) [nucleoplasm]Ubiquitin (Ubb 2) [nucleoplasm]Ubiquitin (Ubc 2) [nucleoplasm]Ubiquitin (Ubb 1) [nucleoplasm]Ubiquitin (Uba52) [nucleoplasm]Ubiquitin (Ubc 1) [nucleoplasm]Ubiquitin (Ubc 3) [nucleoplasm]

UniProtP0CG49UniProtP62983UniProtP0CG50UniProtP62984

Reactome DB_ID: 9790025

UniProt:P51612Xpc

UniProtP51612

ubiquitinylated lysine at unknown position

ubiquitinylated lysine [MOD:01148]

EQUAL

940

EQUAL

Reactome Database ID Release 759790027Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790027ReactomeR-MMU-6782951

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6782951.1Reactome Database ID Release 759790029Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790029ReactomeR-MMU-6782947

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6782947.1

Reactome DB_ID: 5688114

Distorted dsDNA [nucleoplasm]

Distorted dsDNA

Reactome DB_ID: 9789929

PAR-UV-DDB [nucleoplasm]

PAR-UV-DDB

Reactome DB_ID: 3247499

UniProt:P62878 Rbx1

Rbx1

Rbx1FUNCTION E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:22118460). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components (By similarity). As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate (By similarity). Probably also stimulates CDC34 autoubiquitination (By similarity). May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair (By similarity). Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M (By similarity). Involved in the ubiquitination of KEAP1, ENC1 and KLHL41 (By similarity). In concert with ATF2 and CUL3, promotes degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM (By similarity).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B (PubMed:22118460). Interacts with CAND1 (PubMed:22118460). Interacts with UBE2M (By similarity). Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (ELOB and ELOC), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II (By similarity). Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (ELOB and ELOC), CUL2 and MED8; elongin BC complex (ELOB and ELOC), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (ELOB and ELOC), elongin A/ELOA or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Interacts with CDC34. Interacts with GLMN. GLMN competes for the binding site of the E2 ubiquitin-conjugating enzyme CDC34 and disrupts CDC34 binding. Part of a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34 (By similarity). Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1 (By similarity). Interacts with DCUN1D3 (By similarity). Interacts with SESN1 and SESN2 (By similarity). Interacts with NOTCH2 (By similarity). Component of the BCR(KLHL22) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL22 and RBX1 (By similarity).TISSUE SPECIFICITY Widely expressed.DOMAIN The RING-type zinc finger domain is essential for ubiquitin ligase activity (By similarity). It coordinates an additional third zinc ion (PubMed:22118460).SIMILARITY Belongs to the RING-box family.

UniProtP62878

EQUAL

108

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 9785796

CUL4 [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityCul4b [nucleoplasm]Cul4a [nucleoplasm]

UniProtA2A432UniProtQ3TCH7

Reactome DB_ID: 9789927

DDB1:PAR-DDB2 [nucleoplasm]

DDB1:PAR-DDB2

Reactome DB_ID: 9789925

UniProt:Q99J79Ddb2

UniProtQ99J79

L-glutamyl-5-poly(ADP-ribose) at unknown position

L-glutamyl-5-poly(ADP-ribose)

EQUAL

427

EQUAL

Reactome DB_ID: 9785800

UniProt:Q3U1J4Ddb1

UniProtQ3U1J4

EQUAL

1140

EQUAL

Reactome Database ID Release 759789927Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789927ReactomeR-MMU-5696680

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696680.1Reactome Database ID Release 759789929Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789929ReactomeR-MMU-5696649

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696649.1Reactome Database ID Release 759790031Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790031ReactomeR-MMU-5696659

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696659.1Reactome Database ID Release 759790033Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790033ReactomeR-MMU-5696681

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696681.1

Reactome DB_ID: 9789916

TFIIH Core [nucleoplasm]

TFIIH Core

Reactome DB_ID: 9711585

UniProt:Q9DBA9Gtf2h1

UniProtQ9DBA9

EQUAL

548

EQUAL

Reactome DB_ID: 9711573

UniProt:Q8VD76Gtf2h3

UniProtQ8VD76

EQUAL

308

EQUAL

Reactome DB_ID: 9711565

UniProt:O08811Ercc2

UniProtO08811

EQUAL

760

EQUAL

Reactome DB_ID: 9711577

UniProt:Q9JIB4Gtf2h2

UniProtQ9JIB4

EQUAL

395

EQUAL

Reactome DB_ID: 9711589

UniProt:Q8K2X8Gtf2h5

UniProtQ8K2X8

EQUAL

Reactome DB_ID: 9711569

UniProt:P49135Ercc3

UniProtP49135

EQUAL

782

EQUAL

Reactome DB_ID: 9711581

UniProt:O70422Gtf2h4

UniProtO70422

EQUAL

462

EQUAL

Reactome Database ID Release 759789916Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9789916ReactomeR-MMU-5689624

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5689624.1Reactome Database ID Release 759790037Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790037ReactomeR-MMU-5689300

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5689300.1

Reactome DB_ID: 9790832

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm]

Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L

Reactome DB_ID: 9789920

EQUAL

897

EQUAL

Reactome DB_ID: 9790037

Reactome Database ID Release 759790832Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9790832ReactomeR-MMU-5696652

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696652.1Reactome Database ID Release 759792511Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9792511ReactomeR-MMU-5696670

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5696670.1A chromatin remodeling enzyme CHD1L (ALC1) is recruited to DNA damage sites through interaction with PARylated PARP1 (or possibly PARP2) (Ahel et al. 2009) or PARylated DDB2 (Pines et al. 2012). CHD1L catalyzes PARP-stimulated nucleosome sliding and is needed for efficient PARP-dependent DNA repair (Ahel et al. 2009). CHD1L depletion or PARP inhibition impair global genomic nucleotide excision repair (GG-NER) of UV-induced DNA damage (Pines et al. 2012).

19661379Pubmed2009Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1Ahel, DraganaHorejsí, ZuzanaWiechens, NicolaPolo, Sophie EGarcia-Wilson, ElisaAhel, IvanFlynn, HelenSkehel, MarkWest, Stephen CJackson, Stephen POwen-Hughes, TomBoulton, Simon JScience 325:1240-323045548Pubmed2012PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1Pines, AlexVrouwe, Mischa GMarteijn, Jurgen ATypas, DimitrisLuijsterburg, Martijn SCansoy, MedineHensbergen, PaulDeelder, Andréde Groot, AntonMatsumoto, SyotaSugasawa, KaoruThoma, NicolasVermeulen, WimVrieling, HarryMullenders, LeonJ. Cell Biol. 199:235-49inferred by electronic annotationIEAGOIEA