BioPAX pathway converted from "REG3A oligomerize to form a pore complex" in the Reactome database.REG3A oligomerize to form a pore complexREG3A oligomerize to form a pore complexThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 97987396extracellular regionGO0005576REG3A(38-175):anionic phospholipids [extracellular region]REG3A(38-175):anionic phospholipidsConverted from EntitySet in ReactomeReactome DB_ID: 97987371Homologues of REG3A(38-175) [extracellular region]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReg3g [extracellular region]Reg3d [extracellular region]Reg3b [extracellular region]Reg3a [extracellular region]Reactomehttp://www.reactome.orgMus musculusNCBI Taxonomy10090UniProtO09049UniProtQ9QUS9UniProtP35230UniProtO09037Reactome DB_ID: 89317841plasma membraneGO0005886Anionic phospholipids:microbial cell surface [plasma membrane]Anionic phospholipids:microbial cell surfaceReactome DB_ID: 14620491anionic phospholipid [ChEBI:62643]anionic phospholipidphospholipid anionanionic phospholipidsphospholipid anionsChEBI62643Reactome DB_ID: 88791651Microbial cell surface [plasma membrane]Microbial cell surfaceReactome Database ID Release 758931784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8931784ReactomeR-ALL-89317841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8931784.1Reactome Database ID Release 759798739Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798739ReactomeR-MMU-68018041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801804.1Reactome DB_ID: 97987431REG3A hexamer:anionic phospholipid [extracellular region]REG3A hexamer:anionic phospholipidReactome DB_ID: 97987413REG3A dimer:anionic phospholipid [extracellular region]REG3A dimer:anionic phospholipidReactome DB_ID: 97987392Reactome Database ID Release 759798741Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798741ReactomeR-MMU-68017991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801799.1Reactome Database ID Release 759798743Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798743ReactomeR-MMU-68017951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801795.1Reactome Database ID Release 759798745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798745ReactomeR-MMU-68017621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801762.1Regenerating islet-derived 3A (REG3A) is thought to recognize and kill its bacterial targets in two distinct steps (Mukherjee S et al. 2014). First, REG3A is secreted from epithelial cells as a soluble monomer that recognizes Gram-positive bacteria by binding to peptidoglycan carbohydrate via an EPN motif located in the long loop region (Lehotzky RE et al. 2010). Second, REG3A kills bacteria by oligomerizing in the bacterial membrane to form a hexameric membrane-penetrating pore that is predicted to induce uncontrolled ion efflux with subsequent osmotic lysis (Mukherjee S et al. 2014). The inhibitory N-terminus of REG3A propeptide hinders lipid binding and consequently suppresses pore formation until it is removed by trypsin after secretion into the intestinal lumen (Mukherjee S et al. 2009; 2014).24256734Pubmed2014Antibacterial membrane attack by a pore-forming intestinal C-type lectinMukherjee, SohiniZheng, HuiDerebe, Mehabaw GCallenberg, Keith MPartch, Carrie LRollins, DarcyPropheter, Daniel CRizo, JosepGrabe, MichaelJiang, Qiu-XingHooper, Lora VNature 505:103-719095652Pubmed2009Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegmentMukherjee, SohiniPartch, Carrie LLehotzky, Rebecca EWhitham, Cecilia VChu, HiutungBevins, Charles LGardner, Kevin HHooper, Lora VJ. Biol. Chem. 284:4881-820382864Pubmed2010Molecular basis for peptidoglycan recognition by a bactericidal lectinLehotzky, Rebecca EPartch, Carrie LMukherjee, SohiniCash, Heather LGoldman, William EGardner, Kevin HHooper, Lora VProc. Natl. Acad. Sci. U.S.A. 107:7722-7inferred by electronic annotationIEAGOIEAINHIBITIONReactome Database ID Release 756801800Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=6801800ReactomeR-HSA-68018001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-6801800.1Reactome DB_ID: 166005lipopolysaccharide [ChEBI:16412]lipopolysaccharidelipopolysaccharidesLPSChEBI16412