BioPAX pathway converted from "REG3A binds bacterial phospholipids" in the Reactome database.REG3A binds bacterial phospholipidsREG3A binds bacterial phospholipidsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Converted from EntitySet in ReactomeReactome DB_ID: 97987371extracellular regionGO0005576Homologues of REG3A(38-175) [extracellular region]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReg3g [extracellular region]Reg3d [extracellular region]Reg3b [extracellular region]Reg3a [extracellular region]Reactomehttp://www.reactome.orgMus musculusNCBI Taxonomy10090UniProtO09049UniProtQ9QUS9UniProtP35230UniProtO09037Reactome DB_ID: 89317841plasma membraneGO0005886Anionic phospholipids:microbial cell surface [plasma membrane]Anionic phospholipids:microbial cell surfaceReactome DB_ID: 14620491anionic phospholipid [ChEBI:62643]anionic phospholipidphospholipid anionanionic phospholipidsphospholipid anionsChEBI62643Reactome DB_ID: 88791651Microbial cell surface [plasma membrane]Microbial cell surfaceReactome Database ID Release 758931784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8931784ReactomeR-ALL-89317841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-8931784.1Reactome DB_ID: 97987391REG3A(38-175):anionic phospholipids [extracellular region]REG3A(38-175):anionic phospholipidsConverted from EntitySet in ReactomeReactome DB_ID: 97987371Reactome DB_ID: 89317841Reactome Database ID Release 759798739Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798739ReactomeR-MMU-68018041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801804.1Reactome Database ID Release 759798775Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798775ReactomeR-MMU-68017761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801776.1Structural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).24256734Pubmed2014Antibacterial membrane attack by a pore-forming intestinal C-type lectinMukherjee, SohiniZheng, HuiDerebe, Mehabaw GCallenberg, Keith MPartch, Carrie LRollins, DarcyPropheter, Daniel CRizo, JosepGrabe, MichaelJiang, Qiu-XingHooper, Lora VNature 505:103-7inferred by electronic annotationIEAGOIEA