BioPAX pathway converted from "REG3A,REG3G binds bacterial peptidoglycan" in the Reactome database.REG3A,REG3G binds bacterial peptidoglycanREG3A,REG3G binds bacterial peptidoglycanThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 67891981cell wallGO0005618beta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [ChEBI:55424]beta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2Reactomehttp://www.reactome.orgChEBI55424Converted from EntitySet in ReactomeReactome DB_ID: 97987591extracellular regionGO0005576REG3A(38-175), REG3G(38-175) [extracellular region]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReg3g [extracellular region]Reg3d [extracellular region]Reg3b [extracellular region]Reg3a [extracellular region]Mus musculusNCBI Taxonomy10090UniProtO09049UniProtQ9QUS9UniProtP35230UniProtO09037Reactome DB_ID: 97987771REG3A(38-175), REG3G(38-175):peptidoglycan [extracellular region]REG3A(38-175), REG3G(38-175):peptidoglycanReactome DB_ID: 67889571GlcNAc(1-->4)MurNAc:L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [cell wall]GlcNAc(1-->4)MurNAc:L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2PeptidoglycanGlcNAc(1-->4)MurNAc:peptideConverted from EntitySet in ReactomeReactome DB_ID: 97987591Reactome Database ID Release 759798777Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798777ReactomeR-MMU-68018091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801809.1Reactome Database ID Release 759798779Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9798779ReactomeR-MMU-68018081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6801808.1Regenerating islet-derived 3 (REG3) proteins belong to the family of C-type lectins (Cash HL et al. 2006a,b; Lehotzky RE et al. 2010). REG3A and REG3G are induced and expressed in the intestine where they function as antibacterial peptides by targeting the peptidoglycan moieties of bacteria. NMR spectroscopy revealed that human REG3A lectin recognized the peptidoglycan carbohydrate backbone in a calcium-independent manner via a conserved “EPN” motif that is critical for bacterial killing (Lehotzky RE et al. 2010). The antibacterial activities of REG3 proteins are restricted to Gram-positive bacteria and are tightly controlled by an inhibitory N-terminal pro-segment that is removed by trypsin in vivo (Cash HL et al. 2006; Mukherjee S et al. 2009; Medveczky P et al. 2009).19095652Pubmed2009Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegmentMukherjee, SohiniPartch, Carrie LLehotzky, Rebecca EWhitham, Cecilia VChu, HiutungBevins, Charles LGardner, Kevin HHooper, Lora VJ. Biol. Chem. 284:4881-816931762Pubmed2006Symbiotic bacteria direct expression of an intestinal bactericidal lectinCash, Heather LWhitham, Cecilia VBehrendt, Cassie LHooper, Lora VScience 313:1126-3020382864Pubmed2010Molecular basis for peptidoglycan recognition by a bactericidal lectinLehotzky, Rebecca EPartch, Carrie LMukherjee, SohiniCash, Heather LGoldman, William EGardner, Kevin HHooper, Lora VProc. Natl. Acad. Sci. U.S.A. 107:7722-719254208Pubmed2009Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregationMedveczky, PéterSzmola, RichárdSahin-Tóth, MiklósBiochem. J. 420:335-4316504538Pubmed2006Refolding, purification, and characterization of human and murine RegIII proteins expressed in Escherichia coliCash, Heather LWhitham, Cecilia VHooper, Lora VProtein Expr. Purif. 48:151-9inferred by electronic annotationIEAGOIEA