BioPAX pathway converted from "INTL1 binds bacterial glycans" in the Reactome database.INTL1 binds bacterial glycansINTL1 binds bacterial glycansThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 97990141extracellular regionGO0005576ITLN1 trimer:Ca2+ [extracellular region]ITLN1 trimer:Ca2+Reactome DB_ID: 97990123ITLNY1:Ca2+ [extracellular region]ITLNY1:Ca2+Reactome DB_ID: 97990101UniProt:O88310Itln1Reactomehttp://www.reactome.orgMus musculusNCBI Taxonomy10090UniProtO88310Inter-chain Crosslink via L-cystine (cross-link) at 31 and 48 (in Homo sapiens)31EQUALL-cystine (cross-link)ChEBI50058modificationInter-chain Crosslink via L-cystine (cross-link) at 48 and 31 (in Homo sapiens)48EQUALChain Coordinates19EQUAL298EQUALReactome DB_ID: 741123calcium(2+) [ChEBI:29108]calcium(2+)ChEBI29108Reactome Database ID Release 759799012Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799012ReactomeR-MMU-68076281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6807628.1Reactome Database ID Release 759799014Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799014ReactomeR-MMU-68045091Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804509.1Converted from EntitySet in ReactomeReactome DB_ID: 68045351cell wallGO0005618INTL1 ligands [cell wall]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitybeta-D-galactofuranosyl [cell wall]KDO [cell wall]heptose [cell wall]ChEBI59496ChEBI85986ChEBI42976Reactome DB_ID: 97990161INTL1:bacterial glycan [extracellular region]INTL1:bacterial glycanReactome DB_ID: 97990141Converted from EntitySet in ReactomeReactome DB_ID: 68045351Reactome Database ID Release 759799016Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799016ReactomeR-MMU-68045131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804513.1Reactome Database ID Release 759799018Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799018ReactomeR-MMU-68045271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6804527.1Intelectin-1 (INTL1) is a 120-kDa secretory lectin that recognizes multiple glycan epitopes found exclusively on microbes: beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, heptoses, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (Tsuji S et al. 2001; Wesener DA et al. 2015). These glycan residues are widely distributed in bacteria, including S. pneumoniae, Proteus mirabilis, Proteus vulgaris, Yersinia pestis and K. pneumoniae (Wesener DA et al. 2015). The 1.6-A-resolution crystal structure of human INTL1 complexed with beta-Galf suggests that INTL1 binds its carbohydrate ligands bearing terminal 1,2-diols through calcium ion-dependent coordination (Wesener DA et al. 2015).<p>Secreted INTL1 functions as a disulfide-linked trimer (Tsuji S et al., 2001; Tsuji S et al., 2007; Wesener DA et al., 2015).17621593Pubmed2007Differential structure and activity between human and mouse intelectin-1: human intelectin-1 is a disulfide-linked trimer, whereas mouse homologue is a monomerTsuji, ShoutaroYamashita, MakikoNishiyama, AkihitoShinohara, TsutomuLi, ZhongweiMyrvik, Quentin NHoffman, Donald RHenriksen, Ruth AnnShibata, YoshimiGlycobiology 17:1045-5111313366Pubmed2001Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wallTsuji, SUehori, JMatsumoto, MSuzuki, YMatsuhisa, AToyoshima, KSeya, TJ. Biol. Chem. 276:23456-6326148048Pubmed2015Recognition of microbial glycans by human intelectin-1Wesener, Darryl AWangkanont, KittikhunMcBride, RyanSong, XuezhengKraft, Matthew BHodges, Heather LZarling, Lucas CSplain, Rebecca ASmith, David FCummings, Richard DPaulson, James CForest, Katrina TKiessling, Laura LNat. Struct. Mol. Biol. 22:603-10inferred by electronic annotationIEAGOIEA