BioPAX pathway converted from "BPI binds LPS on the bacterial surface" in the Reactome database.BPI binds LPS on the bacterial surfaceBPI binds LPS on the bacterial surfaceThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 68030811cell wallGO0005618lipopolysaccharide [ChEBI:16412]lipopolysaccharidelipopolysaccharidesLPSReactomehttp://www.reactome.orgChEBI16412Reactome DB_ID: 97189581extracellular regionGO0005576UniProt:Q67E05BpiMus musculusNCBI Taxonomy10090UniProtQ67E05Chain Coordinates32EQUAL487EQUALReactome DB_ID: 97996901BPI:LPS [extracellular region]BPI:LPSReactome DB_ID: 68030811Reactome DB_ID: 9718958132EQUAL487EQUALReactome Database ID Release 759799690Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799690ReactomeR-MMU-68075901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6807590.1Reactome Database ID Release 759799692Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9799692ReactomeR-MMU-68075851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-6807585.1Bactericidal permeability-increasing protein (BPI) is a 57-kDa cationic antimicrobial protein that is present principally in the azurophilic granules of polymorphonuclear leukocytes (Elsbach P 1998). BPI has both heparin- and LPS-binding capacity and displays anti-inflammatory activity and direct bactericidal action toward Gram-negative bacteria (Ooi CE et al. 1991; Weiss J et al. 1992; Levy O et al. 2000). Direct bactericidal activity and lipopolysaccharide neutralization are mediated by the N-terminal part of the protein, whereas the C-terminal region has been shown to opsonize bacteria (Iovine NM et al. 1997; Elsbach P & Weiss J 1998).<p>Antineutrophil cytoplasmic autoantibodies against BPI (BPI-ANCA) have been found in diseases of different etiologies, such as cystic fibrosis, TAP deficiency or inflammatory bowel diseases (Walmsley RS et al. 1997; Schultz H et al. 2004; Schinke S et al. 2004; Aichele D et al. 2006). The presence of BPI-ANCA has been shown to correlate with the chronic or profuse exposure of the host to Gram-negative bacteria and their endotoxin (Aebi C et al. 2000; Carlsson M et al. 2003; Schultz H et al. 2003; Schultz H 2007). 9665269Pubmed1998The bactericidal/permeability-increasing protein (BPI) in antibacterial host defenseElsbach, PJ. Leukoc. Biol. 64:14-89155585Pubmed1997Antineutrophil cytoplasm autoantibodies against bactericidal/permeability-increasing protein in inflammatory bowel diseaseWalmsley, R SZhao, M HHamilton, M IBrownlee, AChapman, PPounder, R EWakefield, A JLockwood, C MGut 40:105-914740434Pubmed2003Pseudomonas-induced lung damage in cystic fibrosis correlates to bactericidal-permeability increasing protein (BPI)-autoantibodiesCarlsson, MEriksson, LErwander, IWieslander, JSegelmark, MClin. Exp. Rheumatol. 21:S95-10010749460Pubmed2000Autoantibodies directed against bactericidal/permeability-increasing protein in patients with cystic fibrosis: association with microbial respiratory tract colonizationAebi, CTheiler, FAebischer, C CSchoeni, M HPediatr. Infect. Dis. J. 19:207-1212869032Pubmed2003BPI-ANCA in transporter associated with antigen presentation (TAP) deficiency: possible role in susceptibility to Gram-negative bacterial infectionsSchultz, HSchinke, SWeiss, JCerundolo, VGross, W LGadola, SClin. Exp. Immunol. 133:252-91875165Pubmed1991Endotoxin-neutralizing properties of the 25 kD N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/permeability-increasing protein of human neutrophilsOoi, C EWeiss, JDoerfler, M EElsbach, PJ. Exp. Med. 174:649-559380744Pubmed1997An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domainsIovine, N MElsbach, PWeiss, JProc. Natl. Acad. Sci. U.S.A. 94:10973-814730661Pubmed2004BPI-ANCA of pediatric cystic fibrosis patients can impair BPI-mediated killing of E. coli DH5alpha in vitroSchultz, HendrikSchinke, SusanneMosler, KatharinaHerlyn, KarenSchuster, AntjeGross, Wolfgang LPediatr. Pulmonol. 37:158-641522221Pubmed1992Human bactericidal/permeability-increasing protein and a recombinant NH2-terminal fragment cause killing of serum-resistant gram-negative bacteria in whole blood and inhibit tumor necrosis factor release induced by the bacteriaWeiss, JElsbach, PShu, CCastillo, JGrinna, LHorwitz, ATheofan, GJ. Clin. Invest. 90:1122-3010948134Pubmed2000Enhancement of neonatal innate defense: effects of adding an N-terminal recombinant fragment of bactericidal/permeability-increasing protein on growth and tumor necrosis factor-inducing activity of gram-negative bacteria tested in neonatal cord blood ex vivoLevy, OSisson, R BKenyon, JEichenwald, EMacone, A BGoldmann, DInfect. Immun. 68:5120-516861658Pubmed2006Expression and antimicrobial function of bactericidal permeability-increasing protein in cystic fibrosis patientsAichele, DianaSchnare, MarkusSaake, MarcRöllinghoff, MartinGessner, AndreInfect. Immun. 74:4708-149523110Pubmed1998Role of the bactericidal/permeability-increasing protein in host defenceElsbach, PWeiss, JCurr. Opin. Immunol. 10:45-915626895Pubmed2004Autoantibodies against the bactericidal/permeability-increasing protein from inflammatory bowel disease patients can impair the antibiotic activity of bactericidal/permeability-increasing proteinSchinke, SusanneFellermann, KlausHerlyn, KarenReichel, Philipp HFundke, RilanaStange, Eduard FGross, Wolfgang LSchultz, HendrikInflamm. Bowel Dis. 10:763-7017317612Pubmed2007From infection to autoimmunity: a new model for induction of ANCA against the bactericidal/permeability increasing protein (BPI)Schultz, HendrikAutoimmun Rev 6:223-7inferred by electronic annotationIEAGOIEA