BioPAX pathway converted from "LYZ binds bacterial peptidoglycan" in the Reactome database.LYZ binds bacterial peptidoglycanLYZ binds bacterial peptidoglycanThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 67891981cell wallGO0005618beta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2 [ChEBI:55424]beta-GlcNAc-(1->4)-MurNAc-L-Ala-gamma-D-Glu-L-Lys-(D-Ala)2Reactomehttp://www.reactome.orgChEBI55424Reactome DB_ID: 97961451extracellular regionGO0005576UniProt:P08905Lyz2Mus musculusNCBI Taxonomy10090UniProtP08905Chain Coordinates19EQUAL148EQUALReactome DB_ID: 98053231LYZ:PGN [extracellular region]LYZ:PGNReactome DB_ID: 67891981Reactome DB_ID: 9796145119EQUAL148EQUALReactome Database ID Release 759805323Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9805323ReactomeR-MMU-88622931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8862293.1Reactome Database ID Release 759805325Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9805325ReactomeR-MMU-88623001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8862300.1Human lysozyme (LYZ), also known as 1,4-beta-N-acetylmuramidase C, is found in human secretions such as tears, milk, mucus and saliva (Surna A et al. 2009; Minami J et al. 2015; Sahin O et al. 2016; Masschalck B & Michiels CW. 2003). LYZ functions primarily as a bacteriolytic agent by catalyzing hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in the bacterial cell wall peptidoglycan (Schindler M et al. 1977; Surna A et al. 2009). Nonenzymatic bactericidal activity of LYZ has been documented as well and is generally associated with the cationic properties of LYZ (Ito Y et al. 1997; Nash JA et al. 2006). LYZ acts against both Gram-positive and Gram-negative bacteria such as Peptostreptococcus micros, Eubacterium nodatum, Eikenella corrodens, Fusobacterium periodontium and Campylobacter rectus (Laible & Germaine 1985, Surna A et al. 2009; Tenovuo J 2002). 19179970Pubmed2009Lysozyme and microbiota in relation to gingivitis and periodontitisSurna, AlgimantasKubilius, RicardasSakalauskiene, JurginaVitkauskiene, AstraJonaitis, JuozasSaferis, ViktorasGleiznys, AlvydasMed. Sci. Monit. 15:CR66-7326503736Pubmed2015Lysozyme in breast milk is a selection factor for bifidobacterial colonisation in the infant intestineMinami, JOdamaki, THashikura, NAbe, FXiao, J ZBenef Microbes1-826879979Pubmed2016The serum angiotensin converting enzyme and lysozyme levels in patients with ocular involvement of autoimmune and infectious diseasesSahin, OzlemZiaei, AlirezaKaraismailoğlu, EdaTaheri, NusretBMC Ophthalmol 16:1913816Pubmed1977Mechanism of lysozyme catalysis: role of ground-state strain in subsite D in hen egg-white and human lysozymesSchindler, MAssaf, YSharon, NChipman, D MBiochemistry 16:423-313922894Pubmed1985Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharidesLaible, N JGermaine, G RInfect. Immun. 48:720-816785549Pubmed2006The peptidoglycan-degrading property of lysozyme is not required for bactericidal activity in vivoNash, James ABallard, Tiffany Nicole SWeaver, Timothy EAkinbi, Henry TJ. Immunol. 177:519-2611936452Pubmed2002Clinical applications of antimicrobial host proteins lactoperoxidase, lysozyme and lactoferrin in xerostomia: efficacy and safetyTenovuo, JOral Dis 8:23-914582617Pubmed2003Antimicrobial properties of lysozyme in relation to foodborne vegetative bacteriaMasschalck, BarbaraMichiels, Chris WCrit. Rev. Microbiol. 29:191-2149357984Pubmed1997Bactericidal activity of human lysozymes carrying various lengths of polyproline chain at the C-terminusIto, YKwon, O HUeda, MTanaka, AImanishi, YFEBS Lett. 415:285-8inferred by electronic annotationIEAGOIEA