BioPAX pathway converted from "RNF144A binds PRKDC and Ubiquitin:UBE2L3" in the Reactome database.RNF144A binds PRKDC and Ubiquitin:UBE2L3

RNF144A binds PRKDC and Ubiquitin:UBE2L3

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 9809467

endosome membraneGO0010008

UniProt:Q925F3Rnf144a

Reactomehttp://www.reactome.orgMus musculus

NCBI Taxonomy10090UniProtQ925F3

Chain Coordinates

EQUAL

292

EQUAL

Reactome DB_ID: 9809469

cytosolGO0005829Ub:UBE2L3 [cytosol]

Ub:UBE2L3

Converted from EntitySet in Reactome

Reactome DB_ID: 9707516

Ub [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityUbiquitin (Ubc 3) [cytosol]Ubiquitin (Uba52) [cytosol]Ubiquitin (Ubc 2) [cytosol]Ubiquitin (Ubb 3) [cytosol]Ubb [cytosol]Ubiquitin (Pps27a) [cytosol]Ubiquitin (Ubb 2) [cytosol]Ubiquitin (Ubb 4) [cytosol]Ubiquitin (Ubb 1) [cytosol]Ubiquitin (Ubc 1) [cytosol]

UniProtP0CG50UniProtP62984UniProtP0CG49UniProtP62983

Reactome DB_ID: 9804010

UniProt:P68037Ube2l3

UniProtP68037

S-(glycyl)-L-cysteine (Cys-Gly) at 86 (in Homo sapiens)

EQUAL

S-(glycyl)-L-cysteine (Cys-Gly)

EQUAL

154

EQUAL

Reactome Database ID Release 759809469Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9809469ReactomeR-MMU-8938763

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8938763.1

Reactome DB_ID: 9809463

UniProt:P97313Prkdc

UniProtP97313

EQUAL

4128

EQUAL

Reactome DB_ID: 9809471

RNF144A:PRKDC:Ub:UBE2L3 [cytosol]

RNF144A:PRKDC:Ub:UBE2L3

Reactome DB_ID: 9809467

EQUAL

292

EQUAL

Reactome DB_ID: 9809469

Reactome DB_ID: 9809463

EQUAL

4128

EQUAL

Reactome Database ID Release 759809471Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9809471ReactomeR-MMU-8938767

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8938767.1Reactome Database ID Release 759809473Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9809473ReactomeR-MMU-8938770

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-8938770.1The ubiquitin E3 ligase RNF144A located on endosomal membranes (Ho et al. 2015) binds the catalytic subunit of DNA-dependent protein kinase (PRKDC, DNA-PKcs) and the E2-ubiquitin conjugate UBE2L3:Ubiquitin (UBCH7:Ubiquitin) located in the cytoplasm (Ho et al. 2014).

24979766Pubmed2014RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damageHo, Shiuh-RongMahanic, Christina SLee, Yu-JuLin, Weei-ChinProc. Natl. Acad. Sci. U.S.A. 111:E2646-5526216882Pubmed2015Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane DomainHo, Shiuh-RongLee, Yu-JuLin, Weei-ChinJ. Biol. Chem. 290:23026-38inferred by electronic annotationIEAGOIEA