BioPAX pathway converted from "Inactive G alpha (z) reassociates with G beta:gamma" in the Reactome database. Inactive G alpha (z) reassociates with G beta:gamma Inactive G alpha (z) reassociates with G beta:gamma This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 9810332 1 plasma membrane GO 0005886 G-protein alpha (z):GDP [plasma membrane] G-protein alpha (z):GDP Reactome DB_ID: 9803109 1 UniProt:O70443 Gnaz Reactome http://www.reactome.org Mus musculus NCBI Taxonomy 10090 UniProt O70443 Chain Coordinates 2 EQUAL 355 EQUAL Reactome DB_ID: 114549 1 GDP [ChEBI:17552] GDP Guanosine 5'-diphosphate Guanosine diphosphate ChEBI 17552 Reactome Database ID Release 81 9810332 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9810332 Reactome R-MMU-392006 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-392006.1 Reactome DB_ID: 9781997 1 G-protein beta-gamma complex [plasma membrane] G-protein beta-gamma complex Converted from EntitySet in Reactome Reactome DB_ID: 9781995 1 cytosol GO 0005829 G-protein beta subunit [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity G-protein beta 1 subunit [cytosol] UniProt P62874 Converted from EntitySet in Reactome Reactome DB_ID: 9781988 1 G-protein gamma subunit [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity G-protein gamma 2 subunit [plasma membrane] UniProt P63213 Reactome Database ID Release 81 9781997 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9781997 Reactome R-MMU-167434 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-167434.1 Reactome DB_ID: 9810334 1 Heterotrimeric G-protein Gz (inactive) [plasma membrane] Heterotrimeric G-protein Gz (inactive) Reactome DB_ID: 9810332 1 Reactome DB_ID: 9781997 1 Reactome Database ID Release 81 9810334 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9810334 Reactome R-MMU-391985 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-391985.1 Reactome Database ID Release 81 9810359 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9810359 Reactome R-MMU-750988 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-750988.1 The classical model of G-protein signaling suggests that the G-protein dissociates upon GPCR activation. The active G alpha (z) subunit then participates in signaling, until its intrinsic GTPase activity degrades the bound GTP to GDP. The inactive G alpha (z):GDP complex has much higher affinity for the G beta:gamma complex and consequently reassociates. 15951850 Pubmed 2005 The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits Siderovski, DP Willard, FS Int J Biol Sci 1:51-66 16923326 Pubmed 2006 Structural basis of function in heterotrimeric G proteins Oldham, WM Hamm, HE Q Rev Biophys 39:117-66 inferred by electronic annotation IEA GO IEA