BioPAX pathway converted from "DNA polymerase epsilon binds at the origin" in the Reactome database.DNA polymerase epsilon binds at the originDNA polymerase epsilon binds at the originThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 98215441nucleoplasmGO0005654DNA polymerase epsilon [nucleoplasm]DNA polymerase epsilonReactome DB_ID: 98215421UniProt:D3Z9P5Pole4Reactomehttp://www.reactome.orgRattus norvegicusNCBI Taxonomy10116UniProtD3Z9P5Chain Coordinates2EQUAL117EQUALReactome DB_ID: 98215381UniProt:Q642A5Pole3UniProtQ642A52EQUAL147EQUALReactome DB_ID: 98215291UniProt:D3Z8X4PoleUniProtD3Z8X41EQUAL2286EQUALReactome DB_ID: 98215331UniProt:D4ABZ5Pole2UniProtD4ABZ51EQUAL527EQUALReactome Database ID Release 759821544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821544ReactomeR-RNO-684831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68483.1Reactome DB_ID: 684191origin of replication [nucleoplasm]origin of replicationARSautonomously replicating sequenceoriginReactome DB_ID: 98215461DNA polymerase epsilon:origin complex [nucleoplasm]DNA polymerase epsilon:origin complexReactome DB_ID: 98215441Reactome DB_ID: 684191Reactome Database ID Release 759821546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821546ReactomeR-RNO-684851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68485.1Reactome Database ID Release 759821716Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821716ReactomeR-RNO-689601Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68960.1At the beginning of this reaction, 1 molecule of 'origin of replication', and 1 molecule of 'DNA polymerase epsilon' are present. At the end of this reaction, 1 molecule of 'DNA polymerase epsilon:origin complex' is present.<br><br> <br>12045100Pubmed2002DNA replication in eukaryotic cells.Bell, SPDutta, AAnnu Rev Biochem 71:333-74inferred by electronic annotationIEAGOIEAACTIVATIONReactome Database ID Release 759821608Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821608Reactome DB_ID: 9821605CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm]CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4Reactome DB_ID: 98216031CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm]CDK:DDK:MCM10:active pre-replicative complex:CDC45Reactome DB_ID: 98216011CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm]CDK:DDK:MCM10:active pre-replicative complexReactome DB_ID: 98215991MCM10:active pre-replicative complex [nucleoplasm]MCM10:active pre-replicative complexReactome DB_ID: 98215971active pre-replicative complex [nucleoplasm]active pre-replicative complexReactome DB_ID: 98215031MCM2-7 [nucleoplasm]MCM2-7Reactome DB_ID: 98214971UniProt:Q6AYN8Mcm7UniProtQ6AYN82EQUAL719EQUALReactome DB_ID: 98214931UniProt:A9CMB8Mcm6UniProtA9CMB81EQUAL821EQUALReactome DB_ID: 98214811UniProt:D3ZFP4Mcm3UniProtD3ZFP42EQUAL808EQUALReactome DB_ID: 98214851UniProt:G3V681Mcm4UniProtG3V6812EQUAL863EQUALReactome DB_ID: 98215011UniProt:D3ZP96Mcm2UniProtD3ZP962EQUAL904EQUALReactome DB_ID: 98214891UniProt:A0A0G2JY07Mcm5UniProtA0A0G2JY071EQUAL734EQUALReactome Database ID Release 759821503Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821503ReactomeR-RNO-685581Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68558.1Reactome DB_ID: 98212271CDC6:ORC:origin complex [nucleoplasm]CDC6:ORC:origin complexReactome DB_ID: 98212041UniProt:D3ZRK7Cdc6UniProtD3ZRK71EQUAL560EQUALReactome DB_ID: 98212251ORC:origin of replication [nucleoplasm]ORC:origin of replicationReactome DB_ID: 98211801UniProt:Q6P9Z8Orc4UniProtQ6P9Z81EQUAL436EQUALReactome DB_ID: 98211961UniProt:Q3T1K3Orc6UniProtQ3T1K31EQUAL252EQUALReactome DB_ID: 98212231Orc2 associated with MCM8 [nucleoplasm]Orc2 associated with MCM8Reactome DB_ID: 98211621UniProt:Q75PQ8Orc2UniProtQ75PQ81EQUAL577EQUALReactome DB_ID: 98212211UniProt:D3ZVK1Mcm8UniProtD3ZVK11EQUAL840EQUALReactome Database ID Release 759821223Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821223ReactomeR-RNO-1769701Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-176970.1Reactome DB_ID: 98211721UniProt:A0A0G2K6D6Orc5UniProtA0A0G2K6D61EQUAL435EQUALReactome DB_ID: 98211581UniProt:Q4R180Orc3UniProtQ4R1801EQUAL711EQUALReactome DB_ID: 98211881UniProt:Q80Z32Orc1UniProtQ80Z321EQUAL861EQUALReactome DB_ID: 684191Reactome Database ID Release 759821225Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821225ReactomeR-RNO-685401Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68540.1Reactome Database ID Release 759821227Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821227ReactomeR-RNO-685431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68543.1Reactome Database ID Release 759821597Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821597ReactomeR-RNO-1565621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-156562.1Reactome DB_ID: 98215951UniProt:D3Z8C4Mcm10UniProtD3Z8C41EQUAL875EQUALReactome Database ID Release 759821599Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821599ReactomeR-RNO-1565641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-156564.1Reactome DB_ID: 98215911DDK [nucleoplasm]DDKReactome DB_ID: 98215891UniProt:M0R8P0Dbf4UniProtM0R8P01EQUAL674EQUALReactome DB_ID: 98215851UniProt:D4A8S5Cdc7UniProtD4A8S51EQUAL574EQUALReactome Database ID Release 759821591Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821591ReactomeR-RNO-683881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68388.1Reactome DB_ID: 98215811CDK [nucleoplasm]CDKReactome DB_ID: 98215791UniProt:Q63699Cdk2UniProtQ636991EQUAL298EQUALReactome DB_ID: 98215751Ghost homologue of cyclin [nucleoplasm]Ghost homologue of cyclinReactome Database ID Release 759821581Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821581ReactomeR-RNO-683801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68380.1Reactome Database ID Release 759821601Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821601ReactomeR-RNO-685611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68561.1Reactome DB_ID: 98215731UniProt:B1WBZ4Cdc45UniProtB1WBZ41EQUAL566EQUALReactome Database ID Release 759821603Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821603ReactomeR-RNO-685641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68564.1Reactome DB_ID: 98215691RPA1-4 [nucleoplasm]RPA1-4Reactome DB_ID: 98215611UniProt:D4A845Rpa3UniProtD4A8451EQUAL121EQUALReactome DB_ID: 98215671UniProt:Q63528Rpa2UniProtQ635281EQUAL270EQUALReactome DB_ID: 98215631Ghost homologue of RPA4 [nucleoplasm]Ghost homologue of RPA4Reactome DB_ID: 98215571UniProt:Q7TP21Rpa1UniProtQ7TP212EQUAL616EQUALReactome Database ID Release 759821569Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821569ReactomeR-RNO-685671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68567.1Reactome Database ID Release 759821605Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9821605ReactomeR-RNO-685681Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-68568.1