BioPAX pathway converted from "CYP1A2 hydroxylates AFB1 to AFM1" in the Reactome database. CYP1A2 hydroxylates AFB1 to AFM1 CYP1A2 hydroxylates AFB1 to AFM1 This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 5423605 1 cytosol GO 0005829 aflatoxin B1 [ChEBI:2504] aflatoxin B1 Reactome http://www.reactome.org ChEBI 2504 Reactome DB_ID: 70106 1 hydron [ChEBI:15378] hydron ChEBI 15378 Reactome DB_ID: 29368 1 dioxygen [ChEBI:15379] dioxygen ChEBI 15379 Reactome DB_ID: 29364 1 NADPH(4-) [ChEBI:57783] NADPH(4-) NADPH 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoyl-1,4-dihydropyridin-1-yl)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADPH tetraanion ChEBI 57783 Reactome DB_ID: 29366 1 NADP(3-) [ChEBI:58349] NADP(3-) NADP(+) 2'-O-phosphonatoadenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate} NADP trianion ChEBI 58349 Reactome DB_ID: 5423629 1 aflatoxin M1 [ChEBI:78576] aflatoxin M1 ChEBI 78576 Reactome DB_ID: 29356 1 water [ChEBI:15377] water ChEBI 15377 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 9757210 endoplasmic reticulum membrane GO 0005789 UniProt:P00186 Cyp1a2 Mus musculus NCBI Taxonomy 10090 UniProt P00186 Chain Coordinates 2 EQUAL 515 EQUAL GO 0004497 GO molecular function Reactome Database ID Release 78 9757211 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9757211 Reactome Database ID Release 78 9823470 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9823470 Reactome R-MMU-5423678 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-5423678.1 Aflatoxin B1 (AFB1) undergoes extensive oxidation, which is catalysed by cytochrome P450s. In addition to formation of the 8,9-oxide, oxidation by CYP1A2 yields a stable metabolite, aflatoxin M1 (AFM1), that is excreted in milk and urine (Ueng et al. 1995). AFM1 is less carcinogenic or mutagenic than AFB1, but is equally toxic. 7766804 Pubmed 1995 Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes Ueng, Y F Shimada, T Yamazaki, H Guengerich, F P Chem. Res. Toxicol. 8:218-25 inferred by electronic annotation IEA GO IEA