BioPAX pathway converted from "Methylation of GMP-cap by RNA Methyltransferase" in the Reactome database.2.1.1.56Methylation of GMP-cap by RNA MethyltransferaseMethylation of GMP-cap by RNA MethyltransferaseThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 770871nucleoplasmGO0005654S-adenosyl-L-methionine [ChEBI:15414]S-adenosyl-L-methionineReactomehttp://www.reactome.orgChEBI15414Reactome DB_ID: 98277791Capping complex (with freed 5'- GMP) [nucleoplasm]Capping complex (with freed 5'- GMP)Reactome DB_ID: 294281DNA [nucleoplasm]DNADeoxyribonucleic AcidReactome DB_ID: 98277541CE:Pol II CTD:Spt5 complex [nucleoplasm]CE:Pol II CTD:Spt5 complexReactome DB_ID: 1112601template DNA:30 nt transcript hybrid [nucleoplasm]template DNA:30 nt transcript hybridReactome DB_ID: 98277471UniProt:Q5U2U7RnmtRattus norvegicusNCBI Taxonomy10116UniProtQ5U2U7Chain Coordinates1EQUAL476EQUALReactome DB_ID: 98277301UniProt:D3ZH30RngttUniProtD3ZH301EQUAL597EQUALReactome DB_ID: 98258641TFIIH [nucleoplasm]TFIIHReactome DB_ID: 98258341CAK [nucleoplasm]CAKReactome DB_ID: 98258281UniProt:Q9R1A0CcnhUniProtQ9R1A01EQUAL323EQUALReactome DB_ID: 98258321UniProt:Q8CIR5Mnat1UniProtQ8CIR51EQUAL309EQUALReactome DB_ID: 98258241UniProt:F1LQC8Cdk7UniProtF1LQC81EQUAL346EQUALReactome Database ID Release 759825834Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825834ReactomeR-RNO-692211Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-69221.1Reactome DB_ID: 98258501UniProt:A0JN27Gtf2h2UniProtA0JN271EQUAL395EQUALReactome DB_ID: 98258621UniProt:D3ZEI7Gtf2h5UniProtD3ZEI71EQUAL71EQUALReactome DB_ID: 98258421UniProt:Q4G005Ercc3UniProtQ4G0051EQUAL782EQUALReactome DB_ID: 98258461UniProt:Q561R7Gtf2h3UniProtQ561R71EQUAL308EQUALReactome DB_ID: 98258541UniProt:Q6MG20Gtf2h4UniProtQ6MG201EQUAL462EQUALReactome DB_ID: 98258381UniProt:D3ZEG9Ercc2UniProtD3ZEG91EQUAL760EQUALReactome DB_ID: 98258581UniProt:A0A0G2JWQ0Gtf2h1UniProtA0A0G2JWQ01EQUAL548EQUALReactome Database ID Release 759825864Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9825864ReactomeR-RNO-1096341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-109634.1Reactome DB_ID: 98238531RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm]RNA polymerase II (phosphorylated):TFIIF complexReactome DB_ID: 98238511TFIIF [nucleoplasm]TFIIFReactome DB_ID: 98238451UniProt:Q6AY96Gtf2f1UniProtQ6AY962EQUAL517EQUALReactome DB_ID: 98238491UniProt:Q01750Gtf2f2UniProtQ017502EQUAL249EQUALReactome Database ID Release 759823851Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9823851ReactomeR-RNO-1096311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-109631.1Reactome DB_ID: 98238411RNA Polymerase II holoenzyme complex (phosphorylated) [nucleoplasm]RNA Polymerase II holoenzyme complex (phosphorylated)Reactome DB_ID: 98237871UniProt:D4A5A6Polr2aUniProtD4A5A6O-phospho-L-serine at 5 (in Homo sapiens)5EQUALO-phospho-L-serine [MOD:00046]1EQUAL1970EQUALReactome DB_ID: 98238001UniProt:G3V8Y5Polr2bUniProtG3V8Y51EQUAL1174EQUALReactome DB_ID: 98238041UniProt:D4A259Polr2dUniProtD4A2591EQUAL142EQUALReactome DB_ID: 98238081UniProt:P62489Polr2gUniProtP624891EQUAL172EQUALConverted from EntitySet in ReactomeReactome DB_ID: 98238391Homologues of POLR2L [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityPOLR2L [nucleoplasm]POLR2L [nucleoplasm]UniProtM0RBH0UniProtF1MAS3Reactome DB_ID: 98237961UniProt:D4A531Polr2iUniProtD4A5311EQUAL125EQUALReactome DB_ID: 98238291UniProt:O88828Polr2fUniProtO888282EQUAL127EQUALReactome DB_ID: 98237911UniProt:D3ZQI0Polr2jUniProtD3ZQI01EQUAL117EQUALReactome DB_ID: 98238251UniProt:B0BNE2Polr2eUniProtB0BNE21EQUAL210EQUALReactome DB_ID: 98238121UniProt:Q5EB90Polr2cUniProtQ5EB902EQUAL275EQUALReactome DB_ID: 98238211UniProt:F1LZN9Polr2kUniProtF1LZN91EQUAL58EQUALReactome DB_ID: 98238171UniProt:G3V678LOC100912534UniProtG3V6782EQUAL150EQUALReactome Database ID Release 759823841Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9823841ReactomeR-RNO-1137161Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-113716.1Reactome Database ID Release 759823853Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9823853ReactomeR-RNO-1134041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-113404.1Reactome DB_ID: 98277521UniProt:E9PTB2Supt5hUniProtE9PTB2phosphorylated residue at unknown positionphosphorylated residue [MOD:00696]1EQUAL1087EQUALReactome Database ID Release 759827754Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827754ReactomeR-RNO-770611Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-77061.1Reactome DB_ID: 1113451Nascent pre-mRNA with 5'-GMP dissociated from CE [nucleoplasm]Nascent pre-mRNA with 5'-GMP dissociated from CEReactome Database ID Release 759827779Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827779ReactomeR-RNO-770671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-77067.1Reactome DB_ID: 775021S-adenosyl-L-homocysteine [ChEBI:16680]S-adenosyl-L-homocysteineChEBI16680Reactome DB_ID: 98277831mRNA capping factors [nucleoplasm]mRNA capping factorsReactome DB_ID: 982774711EQUAL476EQUALReactome DB_ID: 982773011EQUAL597EQUALReactome Database ID Release 759827783Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827783ReactomeR-RNO-1134031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-113403.1Reactome DB_ID: 98258641Reactome DB_ID: 98238551RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm]RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNAReactome DB_ID: 720851capped pre-mRNA [nucleoplasm]capped pre-mRNAReactome DB_ID: 98238531Reactome Database ID Release 759823855Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9823855ReactomeR-RNO-1134051Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-113405.1Reactome DB_ID: 98277521phosphorylated residue at unknown position1EQUAL1087EQUALPHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 9827779GO0004482GO molecular functionReactome Database ID Release 759827784Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827784Reactome Database ID Release 759827786Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9827786ReactomeR-RNO-770901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-77090.1In the final step of the capping reaction, the methyltransferase takes a methyl group from S-adenosyl-methionine to the N7 position of the cap guanine. N7G-methyltransferase (MT) mediated reaction can be represented as:<BR>GpppN(pN)n + S-adenosylmethionine (Adomet) ->m7GpppN(pN)n + S-adenosylhomocysteine (Adohcy).<P>9790902Pubmed1998Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.Tsukamoto, TShibagaki, YNiikura, YMizumoto, KBiochem Biophys Res Commun 251:27-34inferred by electronic annotationIEAGOIEA