BioPAX pathway converted from "Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex" in the Reactome database.Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.<br>MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).

Authored: Garapati, P V, 2010-10-29Reviewed: Elliott, T, 2011-02-10Edited: Garapati, P V, 2010-10-29

Reactome DB_ID: 8951496

endoplasmic reticulum membraneGO0005789Antigenic peptide:MHC:B2M peptide loading complex [endoplasmic reticulum membrane]

Antigenic peptide:MHC:B2M peptide loading complex

Reactome DB_ID: 983033

endoplasmic reticulum lumenGO0005788

oligopeptide [ChEBI:25676]

oligopeptide

Oligopeptidoligopeptido

Reactomehttp://www.reactome.orgChEBI25676

Reactome DB_ID: 983121

MHC:B2M peptide loading complex [endoplasmic reticulum membrane]

MHC:B2M peptide loading complex

Reactome DB_ID: 983083

integral component of lumenal side of endoplasmic reticulum membraneGO0071556

UniProt:O15533 TAPBP

TAPBP

TAPANGS17TAPBPFUNCTION Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).SUBUNIT Heterodimer with PDIA3; disulfide-linked. Interacts with TAP1 and is thus a subunit of the TAP complex, also known as the peptide-loading complex (PLC). Interaction with TAP1 is TAP2-independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP (PubMed:19119025, PubMed:21263072). Interacts with HLA-G-B2M complex; this interaction is required for loading of high affinity peptides.TISSUE SPECIFICITY Neutrophils, mostly in fully differentiated cells.DOMAIN The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminal region.POLYMORPHISM The 2 alleles of TAPBP; TAPBP*01 (Tapasin*01) (shown here) and TAPBP*02 (Tapasin*02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population.

Homo sapiens

NCBI Taxonomy9606UniProtO15533

Chain Coordinates

EQUAL

448

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Reactome DB_ID: 985502

UniProt:P27797 CALR

CALR

CRTCCALRFUNCTION Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).SUBUNIT Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 and SPACA9 (By similarity). Interacts with TRIM21 (PubMed:8666824). Interacts with NR3C1 (PubMed:11149926). Interacts with PPIB (PubMed:20801878). Interacts (via P-domain) with PDIA5 (PubMed:23614004). Interacts with GABARAP (PubMed:19154346). Interacts with HLA-E-B2M and HLA-G-B2M complexes (PubMed:9427624, PubMed:9640257). Interacts with HLA-F (PubMed:10605026). Interacts with CLCC1 (PubMed:30157172).DOMAIN Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity.DOMAIN The interaction with glycans occurs through a binding site in the globular lectin domain.DOMAIN The zinc binding sites are localized to the N-domain.DOMAIN Associates with PDIA3 through the tip of the extended arm formed by the P-domain.DISEASE CARL somatic mutations are frequently found in myeloproliferative neoplasms lacking JAK2 or MPL mutations. Myeloproliferative neoplasms are chronic myeloid cancers characterized by overproduction of mature blood cells, and may evolve into acute myeloid leukemia. In addition to chronic myeloid leukemia with the BCR-ABL fusion gene, the three most common myeloproliferative neoplasms are essential thrombocythemia, polycythemia vera, and myelofibrosis.SIMILARITY Belongs to the calreticulin family.CAUTION Was originally thought to be the 52 kDa Ro autoantigen.

UniProtP27797

EQUAL

417

EQUAL

Reactome DB_ID: 983113

TAP [endoplasmic reticulum membrane]

TAP

Transporter associated with antigen processing (TAP)TAP1:TAP2 heterodimer

Reactome DB_ID: 947475

UniProt:Q03519 TAP2

TAP2

ABCB3RING11TAP2Y1PSF2FUNCTION Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.SUBUNIT Heterodimer of TAP1 and TAP2. Interacts with HLA-A*02-B2M complex; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624). Interacts with HLA-F (PubMed:10605026).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus BLNF2a.SUBUNIT (Microbial infection) Interacts with herpes simplex virus ICP47.INDUCTION By IFNG/IFN-gamma.DOMAIN The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.POLYMORPHISM 4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02 (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D, TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01.POLYMORPHISM The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva, cornea and mouth due to exocrine glands dysfunction.SIMILARITY Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.

UniProtQ03519

EQUAL

686

EQUAL

Reactome DB_ID: 947474

UniProt:Q03518 TAP1

TAP1

ABCB2RING4TAP1Y3PSF1FUNCTION Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.SUBUNIT Heterodimer of TAP1 and TAP2. Interacts with HLA-A*02-B2M complex; this interaction is obligatory for the loading of peptide epitopes delivered to the ER by TAP1-TAP2 transporter (PubMed:8805302, PubMed:8630735). Interacts with PSMB5 and PSMB8 (PubMed:15488952). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624). Interacts with HLA-F (PubMed:10605026). Interacts with PSMB5 and PSMB8 (PubMed:15488952).SUBUNIT (Microbial infection) Interacts with Epstein-Barr virus BNLF2a.SUBUNIT (Microbial infection) Interacts with herpes simplex virus ICP47.INDUCTION By IFNG/IFN-gamma.DOMAIN The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2.POLYMORPHISM There are five common alleles; TAP1*01:01 (PSF1A), TAP1*02:01 (PSF1B), TAP1*03:01 (PSF1C), TAP1*01:04 and TAP1*x. The sequence of TAP1*01:01 is shown here.SIMILARITY Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily.CAUTION It is uncertain whether Met-1 or Met-61 is the initiator.

UniProtQ03518

EQUAL

808

EQUAL

Reactome Database ID Release 75983113Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983113ReactomeR-HSA-983113

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983113.1

Reactome DB_ID: 983136

MHC HC:B2M:Erp57 [integral component of lumenal side of endoplasmic reticulum membrane]

MHC HC:B2M:Erp57

Reactome DB_ID: 983063

UniProt:P61769 B2M

B2M

HDCMA22PCDABP0092B2MFUNCTION Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553).SUBUNIT Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M alone (not in complex with HLA-I) interacts with M.tuberculosis EsxA (ESAT-6) and an EsxA-EsxB (CFP-10) complex; the tripartite complex can be detected in the host endoplasmic reticulum (PubMed:25356553). The B2M-EsxA complex can be detected in patients with pleural tuberculosis and is stable from pH 4.0 to 8.0 and in the presence of 2M NaCl (PubMed:25356553). Forms a heterotrimer with HLA-E and a self- or a foreign peptide (PubMed:9427624). Forms a heterotrimer with HLA-G and a self-peptide (PubMed:17056715). Forms a heterotrimer with HLA-F and a self-peptide (PubMed:10605026). Forms a heterotrimer with MR1 and a metabolite antigen.SUBCELLULAR LOCATION (Microbial infection) In the presence of M.tuberculosis EsxA-EsxB complex decreased amounts of B2M are found on the cell surface (PubMed:25356553).PTM Glycation of Ile-21 is observed in long-term hemodialysis patients.SIMILARITY Belongs to the beta-2-microglobulin family.

UniProtP61769

EQUAL

119

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Reactome DB_ID: 901028

UniProt:P30101 PDIA3

PDIA3

PDIA3GRP58ERP57ERP60SUBUNIT Subunit of the TAP complex, also known as the peptide loading complex (PLC). Can form disulfide-linked heterodimers with TAPBP. Interacts with ERP27 and CANX. Interacts with SERPINA2 and with the S and Z variants of SERPINA1. Interacts with ATP2A2 (By similarity).TISSUE SPECIFICITY Detected in the flagellum and head region of spermatozoa (at protein level).SIMILARITY Belongs to the protein disulfide isomerase family.CAUTION Was originally thought to be a phosphatidylinositol 4,5-bisphosphate phosphodiesterase type I (phospholipase C-alpha).

UniProtP30101

EQUAL

505

EQUAL

Reactome DB_ID: 983120

monoglucosylated MHC class I HC [integral component of lumenal side of endoplasmic reticulum membrane]

monoglucosylated MHC class I HC

(Glc)1(Man)9(GlcNAc)2-MHC class I heavy chain

Converted from EntitySet in Reactome

Reactome DB_ID: 983117

Class I MHC heavy chain (MHC HC) [integral component of lumenal side of endoplasmic reticulum membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityclass I MHC B78 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-23 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B54 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-66 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-17 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-6 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-29 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-18 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, alpha chain G precursor [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-31 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-3 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-4 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, alpha chain F precursor [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B14 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B37 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B8 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B18 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-25 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B57 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B58 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B46 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B40 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-5 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B42 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-69 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B51 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-68 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B49 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B39 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-43 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B41 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B52 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B81 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-3 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B73 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-1 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA-H [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B44 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B59 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-33 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-1 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-2 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-30 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-24 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-16 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-15 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B38 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B56 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-8 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA-B [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B82 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-80 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B53 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B7 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B27 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B50 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-12 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-2 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B35 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B55 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B45 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-32 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, E alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B67 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-26 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-74 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-34 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-7 alpha chain precursor [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B13 [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B15 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-11 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, Cw-14 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]class I MHC B47 [integral component of lumenal side of endoplasmic reticulum membrane]HLA class I histocompatibility antigen, A-36 alpha chain [integral component of lumenal side of endoplasmic reticulum membrane]

UniProtP30498UniProtP30447UniProtP30492UniProtP30457UniProtQ95604UniProtQ29963UniProtP30512UniProtQ29865UniProtP17693UniProtP16189UniProtP04222UniProtP30504UniProtP30511UniProtP30462UniProtP18463UniProtP30460UniProtP30466UniProtP18462UniProtP18465UniProtP10319UniProtP30484UniProtQ04826UniProtQ9TNN7UniProtP30480UniProtP10316UniProtP18464UniProtP01891UniProtP30487UniProtP30475UniProtP30456UniProtP30479UniProtP30490UniProtQ31610UniProtP04439UniProtQ31612UniProtP30499UniProtP01893UniProtP30481UniProtQ29940UniProtP16190UniProtP30443UniProtP30501UniProtP16188UniProtP05534UniProtQ29960UniProtQ07000UniProtQ95365UniProtP30495UniProtP30505UniProtP30486UniProtQ29718UniProtQ09160UniProtP30491UniProtP01889UniProtP03989UniProtP30488UniProtP30508UniProtP01892UniProtP30685UniProtP30493UniProtP30483UniProtP10314UniProtP13747UniProtQ29836UniProtP30450UniProtP30459UniProtP30453UniProtP10321UniProtP30461UniProtP30464UniProtP13746UniProtP30510UniProtP30485UniProtP30455

Reactome DB_ID: 532679

N-{alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->3)-[alpha-Man-(1->2)-alpha-Man-(1->6)]-alpha-Man-(1->6)]-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue [ChEBI:59080]

ChEBI59080Reactome Database ID Release 75983120Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983120ReactomeR-HSA-983120

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983120.1Reactome Database ID Release 75983136Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983136ReactomeR-HSA-983136

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983136.1

Reactome DB_ID: 983323

BAP31 oligomer [integral component of lumenal side of endoplasmic reticulum membrane]

BAP31 oligomer

Reactome Database ID Release 75983121Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983121ReactomeR-HSA-983121

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983121.2Reactome Database ID Release 758951496Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=8951496ReactomeR-HSA-8951496

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-8951496.1

Reactome DB_ID: 983083

EQUAL

448

EQUAL

Reactome DB_ID: 983132

Antigen peptide bound class I MHC:BAP31 oligomer [integral component of lumenal side of endoplasmic reticulum membrane]

Antigen peptide bound class I MHC:BAP31 oligomer

Reactome DB_ID: 983127

Peptide bound class I MHC [integral component of lumenal side of endoplasmic reticulum membrane]

Peptide bound class I MHC

Reactome DB_ID: 983033

Reactome DB_ID: 983063

EQUAL

119

EQUAL

Reactome DB_ID: 983120

Reactome Database ID Release 75983127Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983127ReactomeR-HSA-983127

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983127.1

Reactome DB_ID: 983323

Reactome Database ID Release 75983132Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983132ReactomeR-HSA-983132

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983132.1

Reactome DB_ID: 985502

EQUAL

417

EQUAL

Reactome DB_ID: 983113

Reactome DB_ID: 901028

EQUAL

505

EQUAL

Reactome Database ID Release 75983161Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=983161ReactomeR-HSA-983161

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-983161.219851281Pubmed2009Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I moleculesHowe, CGarstka, MAl-Balushi, MGhanem, EAntoniou, ANFritzsche, SJankevicius, GKontouli, NSchneeweiss, CWilliams, AElliott, TSpringer, SEMBO J 28:3730-4417656363Pubmed2007Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytesGarstka, MBorchert, BAl-Balushi, MPraveen, PVKühl, NMajoul, IDuden, RSpringer, SJ Biol Chem 282:30680-9016473882Pubmed2006Structural definition of the H-2Kd peptide-binding motifMitaksov, VFremont, DHJ Biol Chem 281:10618-252038058Pubmed1991Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolutionSaper, MABjorkman, PJWiley, DCJ Mol Biol 219:277-31921050182Pubmed2010The cell biology of major histocompatibility complex class I assembly: towards a molecular understandingVan Hateren, AJames, EBailey, APhillips, ADalchau, NElliott, TTissue Antigens 76:259-75