BioPAX pathway converted from "Phosphorylation of IL2RB Y338 enables SHC recruitment" in the Reactome database.Phosphorylation of IL2RB Y338 enables SHC recruitmentPhosphorylation of IL2RB Y338 enables SHC recruitmentThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 98584251plasma membraneGO0005886IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane]IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3Reactome DB_ID: 98578231UniProt:P26897Il2raReactomehttp://www.reactome.orgRattus norvegicusNCBI Taxonomy10116UniProtP26897Chain Coordinates22EQUAL272EQUALReactome DB_ID: 98583981cytosolGO0005829UniProt:G3V9W2Jak1UniProtG3V9W2O4'-phospho-L-tyrosine at unknown positionO4'-phospho-L-tyrosine [MOD:00048]1EQUAL1154EQUALReactome DB_ID: 98584231UniProt:P26896Il2rbUniProtP26896O4'-phospho-L-tyrosine at 364 (in Homo sapiens)364EQUALO4'-phospho-L-tyrosine at 418 (in Homo sapiens)418EQUALO4'-phospho-L-tyrosine at 536 (in Homo sapiens)536EQUAL27EQUAL551EQUALReactome DB_ID: 98578251extracellular regionGO0005576Ghost homologue of IL2 [extracellular region]Ghost homologue of IL2Reactome DB_ID: 98577441IL2RG:JAK3 [plasma membrane]IL2RG:JAK3Reactome DB_ID: 98577381UniProt:Q7TP53Il2rgUniProtQ7TP5323EQUAL369EQUALReactome DB_ID: 98577421UniProt:Q63272Jak3UniProtQ632721EQUAL1124EQUALReactome Database ID Release 759857744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9857744ReactomeR-RNO-4519111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-451911.1Reactome Database ID Release 759858425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9858425ReactomeR-RNO-4521191Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-452119.1Reactome DB_ID: 98265951UniProt:Q5M824 Shc1Shc1Shc1FUNCTION Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity).SUBUNIT Interacts with CPNE3; this interaction may mediate the binding of CPNE3 with ERBB2 (By similarity). Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR in vitro via the PID domain. Once activated, binds to GRB2. Interacts with tyrosine-phosphorylated CD3T and DDR2. Interacts with the N-terminal region of APS. Interacts with phosphorylated LRP1 and IRS4. Interacts with INPP5D/SHIP1 and INPPL1/SHIP2. Interacts with ALK, GAB2, GRB7 and KIT. Interacts with PTPN6/SHP (tyrosine phosphorylated). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2A, SRC, SHC1, GAP43 and CTTN. Interacts with EPHB1 and GRB2; activates the MAPK/ERK cascade to regulate cell migration. Interacts with PDGFRB (tyrosine-phosphorylated). Interacts with ERBB4. Interacts with TEK/TIE2 (tyrosine-phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with FLT4 (tyrosine-phosphorylated). Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; in a phosphotyrosine-dependent manner. Interacts with CEACAM1; this interaction is CEACAM1-phosphorylation-dependent and mediates interaction with EGFR or INSR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity) (PubMed:11694516). Interacts (via PID domain) with PEAK1 (when phosphorylated) (By similarity). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (By similarity).PTM Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 signaling and by ligand-activated ALK. Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated in response to FLT4 signaling. Tyrosine phosphorylated by activated PTK2B/PYK2.UniProtQ5M8241EQUAL583EQUALReactome DB_ID: 98584271IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane]IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHCReactome DB_ID: 98584251Reactome DB_ID: 982659511EQUAL583EQUALReactome Database ID Release 759858427Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9858427ReactomeR-RNO-4520951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-452095.1Reactome Database ID Release 759858429Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9858429ReactomeR-RNO-4520911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-452091.1Phosphorylation of IL2RB Y338 creates a binding site for the accessory protein SHC, which then becomes tyrosine phosphorylated and recruits the Grb2/Sos and Grb2:Gab2 complexes.8700888Pubmed1996Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferationFriedmann, MCMigone, TSRussell, SMLeonard, WJProc Natl Acad Sci U S A 93:2077-828643566Pubmed1996Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signalingRavichandran, KSIgras, VShoelson, SEFesik, SWBurakoff, SJProc Natl Acad Sci U S A 93:5275-807499411Pubmed1995Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor associationEvans, GAGoldsmith, MAJohnston, JAXu, WWeiler, SRErwin, RHoward, OMAbraham, Robert TO'Shea, JJGreene, WCJ Biol Chem 270:28858-63inferred by electronic annotationIEAGOIEA