BioPAX pathway converted from "IgE binds omalizumab" in the Reactome database. IgE binds omalizumab IgE binds omalizumab This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 9812787 1 extracellular region GO 0005576 IgE [extracellular region] IgE Reactome DB_ID: 9763277 1 Immunoglobulin Kappa Light Chain [extracellular region] Immunoglobulin Kappa Light Chain Reactome DB_ID: 9763141 1 UniProt:P01837 Igkc Igkc Igkc SIMILARITY Contains 1 Ig-like (immunoglobulin-like) domain. Reactome http://www.reactome.org Mus musculus NCBI Taxonomy 10090 UniProt P01837 Chain Coordinates 1 EQUAL 106 EQUAL Converted from EntitySet in Reactome Reactome DB_ID: 9763275 1 Ig Kappa Light Chain V Region [extracellular region] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Igkv20-101-2 [extracellular region] Gm42543 [extracellular region] Igkv8-21 [extracellular region] Igkv1-35 [extracellular region] Igkv1-133 [extracellular region] Ighv1-4 [extracellular region] Gm5571 [extracellular region] Igkv17-121 [extracellular region] Igkv20-101-2 [extracellular region] Igkv9-123 [extracellular region] Gm5571 [extracellular region] Igkv20-101-2 [extracellular region] Igkv17-127 [extracellular region] Igkv1-135 [extracellular region] Igkv9-124 [extracellular region] Gm42543 [extracellular region] Igkv13-84 [extracellular region] Igkv1-35 [extracellular region] Ighv1-80 [extracellular region] Gm5153 [extracellular region] Igkv18-36 [extracellular region] Igkv10-95 [extracellular region] Igkv2-137 [extracellular region] Gm42543 [extracellular region] Igkv10-96 [extracellular region] Igkv9-123 [extracellular region] Igkv10-94 [extracellular region] Igkv10-94 [extracellular region] Igkv10-96 [extracellular region] Igkv9-124 [extracellular region] Igkv1-132 [extracellular region] Igkv1-131 [extracellular region] Igkv10-95 [extracellular region] UniProt A0A0G2JDU3 UniProt A0A0G2JET4 UniProt A0A140T8P7 UniProt A0A075B5N0 UniProt A0A0B4J1H8 UniProt A0A075B5T4 UniProt P01639 UniProt A0A075B5K3 UniProt A0A140T8N8 UniProt A0A075B5J9 UniProt A0A0B4J1H7 UniProt A0A075B5K2 UniProt A0A140T8N3 UniProt A0A075B5Y3 UniProt P01627 UniProt A0A075B5M9 UniProt A0A075B5L0 UniProt A0A0B4J1H6 UniProt A0A140T8M1 UniProt A0A075B5L1 UniProt A0A0B4J1H9 UniProt A0A140T8M8 Reactome Database ID Release 78 9763277 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9763277 Reactome R-MMU-983670 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-983670.1 Reactome DB_ID: 9812785 1 IgE Heavy Chain [extracellular region] IgE Heavy Chain Converted from EntitySet in Reactome Reactome DB_ID: 9763641 1 Ig Heavy Chain V Region [extracellular region] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Ighv8-12 [extracellular region] Ighv1-61 [extracellular region] Ighv1-12 [extracellular region] Ighv1-55 [extracellular region] Ighv1-78 [extracellular region] Ighv1-23 [extracellular region] Ighv1-47 [extracellular region] Ighv5-6 [extracellular region] Ighv3-1 [extracellular region] Ighv1-63 [extracellular region] Ighv5-12 [extracellular region] Ighv1-26 [extracellular region] Ighv1-80 [extracellular region] Ighv5-12-4 [extracellular region] Ighv1-58 [extracellular region] Ighv1-75 [extracellular region] Ighv3-8 [extracellular region] Ighv12-3 [extracellular region] Ighv1-20 [extracellular region] Ighv1-64 [extracellular region] Ighv8-4 [extracellular region] Ighv1-11 [extracellular region] Ighv8-11 [extracellular region] Ighv1-85 [extracellular region] Ighv3-1 [extracellular region] Ighv3-6 [extracellular region] Ighv1-18 [extracellular region] Ighv1-43 [extracellular region] Ighv8-13 [extracellular region] Ighv14-1 [extracellular region] Ighv8-6 [extracellular region] Ighv1-74 [extracellular region] Ighv3-6 [extracellular region] Ighv5-17 [extracellular region] Ighv5-9 [extracellular region] Ighv1-67 [extracellular region] Ighv1-15 [extracellular region] Ighv5-16 [extracellular region] Ighv12-3 [extracellular region] Ighv1-24 [extracellular region] Ighv1-62-2 [extracellular region] Ighv1-37 [extracellular region] Ighv8-5 [extracellular region] Ighv14-3 [extracellular region] Ighv3-4 [extracellular region] Ighv8-9 [extracellular region] Ighv1-56 [extracellular region] Ighv5-2 [extracellular region] P18533 [extracellular region] Ighv1-16 [extracellular region] Ighv1-54 [extracellular region] Ighv1-39 [extracellular region] Ighv11-2 [extracellular region] Ighv1-4 [extracellular region] Ighv1-77 [extracellular region] Gm5629 [extracellular region] Ighv1-4 [extracellular region] Ighv1-42 [extracellular region] Ighv3-4 [extracellular region] Ighv1-22 [extracellular region] Ighv1-19 [extracellular region] Ighv1-49 [extracellular region] Ighv5-12 [extracellular region] Ighv8-8 [extracellular region] Ighv1-31 [extracellular region] Ighv1-50 [extracellular region] Ighv4-1 [extracellular region] Ighv1-59 [extracellular region] Ighv3-8 [extracellular region] Ighv5-15 [extracellular region] Ighv1-52 [extracellular region] Ighv1-53 [extracellular region] Ighv1-69 [extracellular region] Ighv5-4 [extracellular region] Ighv15-2 [extracellular region] Ighv1-80 [extracellular region] Ighv1-34 [extracellular region] Ighv5-9-1 [extracellular region] Ighv3-3 [extracellular region] Ighv3-3 [extracellular region] Ighv8-2 [extracellular region] Ighv1-66 [extracellular region] Ighv14-4 [extracellular region] Ighv1-82 [extracellular region] Ig heavy chain V-II region ARH-77 [extracellular region] Ighv1-5 [extracellular region] Ighv1-62-3 [extracellular region] Ighv14-2 [extracellular region] Ighv1-7 [extracellular region] Ighv11-1 [extracellular region] Ighv1-76 [extracellular region] Ighv1-9 [extracellular region] Ighv1-72 [extracellular region] Ighv1-36 [extracellular region] Ighv1-81 [extracellular region] UniProt A0A075B5X8 UniProt P01749 UniProt A0A075B5U0 UniProt A0A075B5W6 UniProt A0A075B674 UniProt A0A0A6YVW3 UniProt A0A075B5V8 UniProt A0A075B5Q0 UniProt A0A075B5S6 UniProt A0A075B5X2 UniProt A0A075B5Q4 UniProt A0A075B5V0 UniProt A0A0A6YWG4 UniProt A0A075B5W9 UniProt A0A075B5Y2 UniProt A0A075B5T0 UniProt A0A075B5T1 UniProt A0A075B5U6 UniProt A0A075B5X3 UniProt A0A075B693 UniProt A0A0A6YWI9 UniProt A0A075B5X4 UniProt A0A075B5Y6 UniProt P18531 UniProt A0A075B5U4 UniProt A0A075B5V7 UniProt A0A075B5Y0 UniProt A0A075B5R4 UniProt A0A075B5W4 UniProt A0A075B5Y1 UniProt A0A075B5R1 UniProt A0A075B5Q2 UniProt A0A075B5X6 UniProt A0A0A6YXA5 UniProt A0A075B5R0 UniProt A0A075B5U9 UniProt A0A075B680 UniProt A0A075B5V4 UniProt A0A0A6YY60 UniProt A0A075B5R9 UniProt A0A0A6YXF1 UniProt A0A075B5X1 UniProt A0A075B5W7 UniProt A0A075B5P7 UniProt P18533 UniProt A0A075B5U1 UniProt A0A075B5W5 UniProt A0A075B5V5 UniProt A0A075B5R8 UniProt A0A0B4J1M0 UniProt P06327 UniProt A0A075B5V6 UniProt A0A075B5U7 UniProt A0A075B5U5 UniProt A0A075B5V9 UniProt A0A0A6YXQ0 UniProt A0A075B5V1 UniProt A0A075B5W1 UniProt A0A075B5R5 UniProt A0A075B5X0 UniProt A0A075B5Q9 UniProt A0A075B5W2 UniProt A0A075B5W3 UniProt A0A075B5X7 UniProt A0A075B5P9 UniProt A0A075B5T8 UniProt A0A075B5V2 UniProt A0A075B5Q6 UniProt A0A075B5S4 UniProt A0A0A6YW58 UniProt A0A075B5X5 UniProt A0A075B5S3 UniProt A0A0B4J1J7 UniProt A0A075B5T5 UniProt P01754 UniProt A0A075B5R7 UniProt A0A075B5T7 UniProt A0A075B5R6 UniProt A0A0B4J1N0 UniProt A0A075B5T9 UniProt P06328 UniProt A0A075B5V3 UniProt A0A075B5Y4 Reactome DB_ID: 9812783 1 Ghost homologue of IGHE [extracellular region] Ghost homologue of IGHE Reactome Database ID Release 78 9812785 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9812785 Reactome R-MMU-1591209 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1591209.1 Reactome Database ID Release 78 9812787 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9812787 Reactome R-MMU-1591211 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-1591211.1 Reactome DB_ID: 9724689 1 omalizumab [Guide to Pharmacology:6890] omalizumab Xolair&reg; RG-3648 R03DX05 rhumab-E25 olizumab IGE25 Guide to Pharmacology 6890 Reactome DB_ID: 9859717 1 IgE:omalizumab [extracellular region] IgE:omalizumab Reactome DB_ID: 9812787 1 Reactome DB_ID: 9724689 1 Reactome Database ID Release 78 9859717 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9859717 Reactome R-MMU-9724684 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9724684.1 Reactome Database ID Release 78 9859719 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9859719 Reactome R-MMU-9724685 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-9724685.1 When bound to the high-affinity IgE receptor (FCERI), IgE acts as an environmental sensor that detects allergens and induces allergic responses from the cell's interior. Omalizumab is a monoclonal antibody that binds free IgE preventing it from binding to FCERI. Moreover, reduction of free IgE concentrations reduce FCERI expression level. Omalizumab is approved for the treatment of patients with severe allergic asthma. Use of omalizumab is associated with several side effects, including injection site reactions, viral and upper respiratory tract infections, headache, sinusitis, and pharyngitis. The main severe adverse effect is anaphylactic shock, with a rate of occurrence of 1 to 2 patients per 1,000 (Davydov 2005, Arm et al. 2014). 15686303 Pubmed 2005 Omalizumab (Xolair) for treatment of asthma Davydov, Liya Am Fam Physician 71:341-2 25200415 Pubmed 2014 Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects Arm, J P Bottoli, I Skerjanec, A Floch, D Groenewegen, A Maahs, S Owen, C E Jones, I Lowe, P J Clin. Exp. Allergy 44:1371-85 inferred by electronic annotation IEA GO IEA