BioPAX pathway converted from "ISGylation of host proteins" in the Reactome database.6.3.2.19ISGylation of host proteinsISGylation of host proteinsThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 98676201cytosolGO0005829ISG15:UBCH8:ISG15 E3 ligase [cytosol]ISG15:UBCH8:ISG15 E3 ligaseReactome DB_ID: 98676081ISG15:UBCH8 [cytosol]ISG15:UBCH8Reactome DB_ID: 98676061UniProt:D4A3X3Isg15Reactomehttp://www.reactome.orgRattus norvegicusNCBI Taxonomy10116UniProtD4A3X3Chain Coordinates2EQUAL157EQUALReactome DB_ID: 98654871UniProt:Q4V8J2Ube2l6UniProtQ4V8J21EQUAL153EQUALReactome Database ID Release 759867608Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867608ReactomeR-RNO-11693851Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-1169385.1Converted from EntitySet in ReactomeReactome DB_ID: 98676181ISG15 E3 ligases [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityArih1 [cytosol]UniProtD3ZXL1Reactome Database ID Release 759867620Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867620ReactomeR-RNO-11693831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-1169383.1Reactome DB_ID: 1135921ATP(4-) [ChEBI:30616]ATP(4-)Adenosine 5'-triphosphateatpATPChEBI30616Converted from EntitySet in ReactomeReactome DB_ID: 98676711ISG15 targets [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityJak1 [cytosol]Mapk3 [cytosol]Ube2e1 [cytosol]Stat1 [cytosol]Plcg1 [cytosol]UniProtG3V9W2UniProtP21708UniProtF1M3L4UniProtA0A0G2JX93UniProtP10686Reactome DB_ID: 765771adenosine 5'-monophosphate [ChEBI:16027]adenosine 5'-monophosphateChEBI16027Reactome DB_ID: 986548711EQUAL153EQUALReactome DB_ID: 98676731ISGylated host proteins [cytosol]ISGylated host proteinsReactome DB_ID: 986760612EQUAL157EQUALConverted from EntitySet in ReactomeReactome DB_ID: 98676711Reactome Database ID Release 759867673Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867673ReactomeR-RNO-11693871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-1169387.1Reactome DB_ID: 1112941diphosphoric acid [ChEBI:29888]diphosphoric acidChEBI29888Converted from EntitySet in ReactomeReactome DB_ID: 98676181PHYSIOL-LEFT-TO-RIGHTACTIVATIONReactome DB_ID: 9867620GO0004842GO molecular functionReactome Database ID Release 759867623Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867623Reactome Database ID Release 759867675Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9867675ReactomeR-RNO-11694061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-1169406.1Many host proteins are targets for ISGylation including constitutively expressed proteins involved in various cellular pathways such as immunity, RNA splicing, chromatin remodeling/polymerase II transcription, stress responses and translation. Many ISG15 target proteins are IFN alpha/beta-induced antiviral proteins such as PKR, MxA, IRF3, and RIG-I, also included are several key regulators of signal transduction such as PLC gamma1, JAK1, STAT1 and ERK1. The contribution of most of these modified proteins to antiviral activity is unclear because the fate of the vast majority of ISGylated target proteins is unknown.12582176Pubmed2003High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transductionMalakhov, MPKim, KIMalakhova, OAJacobs, BSBorden, ECZhang, DEJ Biol Chem 278:16608-1316139798Pubmed2005Proteomic identification of proteins conjugated to ISG15 in mouse and human cellsGiannakopoulos, NVLuo, JKPapov, VZou, WLenschow, DJJacobs, BSBorden, ECLi, JVirgin, HWZhang, DEBiochem Biophys Res Commun 336:496-50616009940Pubmed2005Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathwaysZhao, CDenison, CHuibregtse, JMGygi, SKrug, RMProc Natl Acad Sci U S A 102:10200-5inferred by electronic annotationIEAGOIEA