BioPAX pathway converted from "WWTR1 (TAZ) binds ZO-2 (TJP2)" in the Reactome database. WWTR1 (TAZ) binds ZO-2 (TJP2) WWTR1 (TAZ) binds ZO-2 (TJP2) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 9873866 1 cytosol GO 0005829 UniProt:Q9Z0U1 Tjp2 Reactome http://www.reactome.org Mus musculus NCBI Taxonomy 10090 UniProt Q9Z0U1 Chain Coordinates 1 EQUAL 1190 EQUAL Reactome DB_ID: 9873226 1 UniProt:Q9EPK5 Wwtr1 Wwtr1 Wwtr1 Taz FUNCTION Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:11118213). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (By similarity). WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation (By similarity). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (By similarity). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (By similarity).SUBUNIT Binds to SLC9A3R2 via the PDZ motif at the plasma membrane (PubMed:11118213). Binds to YWHAZ in vivo and in vitro through the phosphoserine-binding motif RSHSSP (PubMed:11118213). Interacts (via coiled-coil domain) with SMAD2 (via MH1 domain), SMAD3 and SMAD4 (By similarity). Interacts with MED15 (By similarity). Interacts with PAX8 and NKX2-1 (By similarity). Interacts with TEAD1, TEAD2, TEAD3 and TEAD4 (By similarity). Interacts (via WW domain) with PALS1 (PubMed:21145499). Interacts with LATS1 (PubMed:21145499). Interacts with YAP1 (when phosphorylated at 'Ser-112') (PubMed:21145499). Interacts (via WW domain) with PRRG4 (via cytoplasmic domain) (By similarity).TISSUE SPECIFICITY Highly expressed in kidney, heart, placenta and lung.DOMAIN The PDZ-binding motif is essential for stimulated gene transcription. It localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.DOMAIN Binds to transcription factors via its WW domain.PTM Phosphorylated by LATS2 and STK3/MST2. Phosphorylation by LATS2 results in creation of 14-3-3 binding sites, retention in the cytoplasm, and functional inactivation (By similarity). Phosphorylation results in the inhibition of transcriptional coactivation through YWHAZ-mediated nuclear export. UniProt Q9EPK5 1 EQUAL 400 EQUAL Reactome DB_ID: 9873882 1 WWTR1:TJP2 [cytosol] WWTR1:TJP2 Reactome DB_ID: 9873866 1 1 EQUAL 1190 EQUAL Reactome DB_ID: 9873226 1 1 EQUAL 400 EQUAL Reactome Database ID Release 82 9873882 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9873882 Reactome R-MMU-2064405 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2064405.1 Reactome Database ID Release 82 9873884 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9873884 Reactome R-MMU-2064418 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-MMU-2064418.1 Cytosolic ZO-2 (TJP2) binds WWTR1 (TAZ) to form a complex. This event may play a role in sequestering WWTR1 in the cytosol (Remue et al. 2010). The phosphorylation state of the WWTR1 protein involved in this interaction has not been determined experimentally; it is inferred to be unphosphorylated. 20850437 Pubmed 2010 TAZ interacts with zonula occludens-1 and -2 proteins in a PDZ-1 dependent manner Remue, E Meerschaert, K Oka, T Boucherie, C Vandekerckhove, J Sudol, M Gettemans, J FEBS Lett 584:4175-80 inferred by electronic annotation IEA GO IEA