BioPAX pathway converted from "p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTP" in the Reactome database.p-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTPp-Y281,292-RUFY1 binds RAB4A:GTP, RAB5:GTP, RAB14:GTPThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 99180041early endosome membraneGO0031901RAB4A:GTP [early endosome membrane]RAB4A:GTPReactome DB_ID: 99180021UniProt:P05714Rab4aReactomehttp://www.reactome.orgRattus norvegicusNCBI Taxonomy10116UniProtP05714Chain Coordinates1EQUAL218EQUALReactome DB_ID: 21301701GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBI15996Reactome Database ID Release 759918004Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9918004ReactomeR-RNO-88713671Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8871367.1Reactome DB_ID: 99179961UniProt:F1LR42Rufy1UniProtF1LR42O4'-phospho-L-tyrosine at 281 (in Homo sapiens)281EQUALO4'-phospho-L-tyrosine [MOD:00048]O4'-phospho-L-tyrosine at 292 (in Homo sapiens)292EQUAL1EQUAL708EQUALReactome DB_ID: 99180081RAB5A:GTP [early endosome membrane]RAB5A:GTPReactome DB_ID: 99180061Ghost homologue of RAB5A [early endosome membrane]Ghost homologue of RAB5AReactome DB_ID: 21301701Reactome Database ID Release 759918008Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9918008ReactomeR-RNO-21301911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-2130191.1Reactome DB_ID: 99180001RAB14:GTP [early endosome membrane]RAB14:GTPReactome DB_ID: 21301701Reactome DB_ID: 99179981UniProt:P61107 Rab14Rab14Rab14FUNCTION Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes.SUBUNIT Interacts with KIF16B. Interacts with ZFYVE20 (By similarity).TISSUE SPECIFICITY Widely expressed (at protein level). Highest levels found in whole brain, spinal cord, heart, kidney and lung.SIMILARITY Belongs to the small GTPase superfamily. Rab family.UniProtP611072EQUAL215EQUALReactome Database ID Release 759918000Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9918000ReactomeR-RNO-88713771Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8871377.1Reactome DB_ID: 99180101p-Y281,292-RUFY1:p-Y281,292-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTP [early endosome membrane]p-Y281,292-RUFY1:p-Y281,292-RUFY1:RAB4A:GTP:RAB5:GTP:RAB14:GTPReactome DB_ID: 99180041Reactome DB_ID: 99179961O4'-phospho-L-tyrosine at 281 (in Homo sapiens)281EQUALO4'-phospho-L-tyrosine at 292 (in Homo sapiens)292EQUAL1EQUAL708EQUALReactome DB_ID: 99180081Reactome DB_ID: 99180001Reactome Database ID Release 759918010Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9918010ReactomeR-RNO-88713531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8871353.1Reactome Database ID Release 759918012Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9918012ReactomeR-RNO-88713661Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8871366.1RUN and FYVE domain-containing protein 1 (RUFY1, aka RABIP4, ZFYVE12), together with Ras-related proteins RAB4A, 5 and 14, could play an important role in GLUT4 trafficking in adipocytes and skeletal muscle (Kitagishi & Matsuda 2013, Larance et al. 2005, Mari et al. 2006, Fouraux et al. 2004).16522682Pubmed2006The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytesMari, MurielMonzo, PascaleKaddai, VincentKeslair, FrédériqueGonzalez, TeresaLe Marchand-Brustel, YannickCormont, MireilleJ. Cell. Sci. 119:1297-30623519112Pubmed2013RUFY, Rab and Rap Family Proteins Involved in a Regulation of Cell Polarity and Membrane TraffickingKitagishi, YasukoMatsuda, SatoruInt J Mol Sci 14:6487-9816154996Pubmed2005Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 traffickingLarance, MarkRamm, GeorgStöckli, Jacquelinevan Dam, Ellen MWinata, StephanieWasinger, ValerieSimpson, FionaGraham, MichaelJunutula, Jagath RGuilhaus, MichaelJames, DEJ. Biol. Chem. 280:37803-1314617813Pubmed2004Rabip4' is an effector of rab5 and rab4 and regulates transport through early endosomesFouraux, Michael ADeneka, MagdaIvan, Vioricavan der Heijden, AnnemarieRaymackers, Josvan Suylekom, Denisevan Venrooij, Walther Jvan der Sluijs, PeterPruijn, Ger J MMol. Biol. Cell 15:611-24inferred by electronic annotationIEAGOIEA