BioPAX pathway converted from "RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)" in the Reactome database.RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

RUNX3 binds CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>

Reactome DB_ID: 9916437

nucleoplasmGO0005654

UniProt:A0A0G2K9V0Runx3

Reactomehttp://www.reactome.orgRattus norvegicus

NCBI Taxonomy10116UniProtA0A0G2K9V0

Chain Coordinates

EQUAL

415

EQUAL

Reactome DB_ID: 9841699

TCF/LEF:CTNNB1 [nucleoplasm]

TCF/LEF:CTNNB1

Reactome DB_ID: 9841557

UniProt:Q9WU82Ctnnb1

UniProtQ9WU82

EQUAL

781

EQUAL

Converted from EntitySet in Reactome

Reactome DB_ID: 9841697

TCF/LEF [nucleoplasm]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityLef1 [nucleoplasm]Tcf7l2 [nucleoplasm]

UniProtQ9QXN1UniProtD4A8X6Reactome Database ID Release 759841699Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9841699ReactomeR-RNO-3299548

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-3299548.1

Reactome DB_ID: 9921318

RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7) [nucleoplasm]

RUNX3:CTNNB1:TCF7L2,(LEF1,TCF7L1,TCF7)

Reactome DB_ID: 9841699

Reactome DB_ID: 9916437

EQUAL

415

EQUAL

Reactome Database ID Release 759921318Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9921318ReactomeR-RNO-8951432

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8951432.1Reactome Database ID Release 759921320Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9921320ReactomeR-RNO-8951428

Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-8951428.1RUNX3 forms a ternary complex with beta-catenin (CTNNB1) and its binding partner TCF7L2 (TCF4). In addition to TCF7L2, RUNX3 is also able to interact with LEF1, TCF7L1 (TCF3) and TCF7 (also known as TCF1). The interaction involves the Runt domain of RUNX3 and the HMG box of TCF7L2 (Ito et al. 2008).

18772112Pubmed2008RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesisIto, KoseiLim, Anthony Chee-BengSalto-Tellez, ManuelMotoda, LenaOsato, MotomiChuang, Linda Shyue HueyLee, Cecilia Wei LinVoon, Dominic Chih-ChengKoo, Jason Kin WaiWang, HuajingFukamachi, HiroshiIto, YoshiakiCancer Cell 14:226-37inferred by electronic annotationIEAGOIEA