BioPAX pathway converted from "Activation of conventional Protein Kinase C" in the Reactome database. Activation of conventional Protein Kinase C Activation of conventional Protein Kinase C This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 33625 1 plasma membrane GO 0005886 3-sn-phosphatidyl-L-serine [ChEBI:11750] 3-sn-phosphatidyl-L-serine L-alpha-phosphatidylserine 3-sn-phosphatidyl-L-serines 3-L-phosphatidyl-L-serine 1-D-phosphatidyl-L-serine 1,2-diacyl-sn-glycerol 3-phospho-L-serine 3-O-sn-phosphatidyl-L-serine Reactome http://www.reactome.org ChEBI 11750 Reactome DB_ID: 74016 1 cytosol GO 0005829 calcium(2+) [ChEBI:29108] calcium(2+) ChEBI 29108 Reactome DB_ID: 114519 1 1,2-diacyl-sn-glycerol [ChEBI:17815] 1,2-diacyl-sn-glycerol ChEBI 17815 Converted from EntitySet in Reactome Reactome DB_ID: 9938282 1 Protein Kinase C, conventional [cytosol] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity PRKCG [cytosol] PRKCB [cytosol] PRKCA [cytosol] Rattus norvegicus NCBI Taxonomy 10116 UniProt P63319 UniProt P68403 UniProt P05696 Converted from EntitySet in Reactome Reactome DB_ID: 9938294 1 Activated conventional protein kinase C [plasma membrane] Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntity Reactome Database ID Release 82 9938296 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9938296 Reactome R-RNO-114553 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-114553.1 The conventional Protein Kinase C (cPKC) isoforms have two membrane-targetting domains, a C1 domain which binds to the membrane lipid diacylglycerol (DAG) and a C2 domain which binds membrane phospholipids such as phosphatidylserine, in a calcium-dependent manner. Association of both domains with the plasma membrane produces a conformational change that releases an autoinhibitory pseudosubstrate segment from the substrate-binding cavity, allowing substrate binding and downstream signaling. 9601053 Pubmed 1998 The extended protein kinase C superfamily Mellor, H Parker, PJ Biochem J 332:281-92 9814702 Pubmed 1998 Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals Oancea, E Meyer, T Cell 95:307-18 19033211 Pubmed 2009 Lipid activation of protein kinases Newton, AC J Lipid Res 50:S266-71 9780306478635 ISBN 2004 Protein Kinase C 2nd ed Dekker, L Protein Kinase C 2nd ed (Book) inferred by electronic annotation IEA GO IEA ACTIVATION Reactome Database ID Release 82 425851 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=425851 Reactome R-HSA-425851 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-HSA-425851.1 Reactome DB_ID: 114519