BioPAX pathway converted from "Association of LBP with LPS" in the Reactome database.Association of LBP with LPSAssociation of LBP with LPSThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 99446851extracellular regionGO0005576UniProt:F1Q3I0Reactomehttp://www.reactome.orgCanis familiarisNCBI Taxonomy9615UniProtF1Q3I0Chain Coordinates26EQUAL481EQUALReactome DB_ID: 1660051lipopolysaccharide [ChEBI:16412]lipopolysaccharidelipopolysaccharidesLPSChEBI16412Reactome DB_ID: 99446871LBP:bacterial LPS [extracellular region]LBP:bacterial LPSReactome DB_ID: 9944685126EQUAL481EQUALReactome DB_ID: 1660051Reactome Database ID Release 759944687Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9944687ReactomeR-CFA-1660131Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-166013.1Reactome Database ID Release 759944693Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9944693ReactomeR-CFA-1660151Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-166015.1Lipopolysaccharide-binding protein (LBP) is a ~60-kDa serum glycoprotein which transfers LPS to both membrane-bound and soluble CD14. The LPS binding site of LBP consists of basic residues that bind the phosphorylated head of the bacterial lipid A. <p>LBP is an acute-phase opsonin that binds gram-negative bacteria and bacterial fragments and promote the interaction of coated bacteria with phagocytes. 1698311Pubmed1990CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding proteinWright, SDRamos, RATobias, PSUlevitch, RJMathison, JCScience 249:1431-319269309Pubmed2009Cationic lipids activate cellular cascades. Which receptors are involved?Lonez, CLensink, MFVandenbranden, MRuysschaert, JMBiochim Biophys Acta 1790:425-302477488Pubmed1989Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particlesWright, SDTobias, PSUlevitch, RJRamos, RAJ Exp Med 170:1231-41inferred by electronic annotationIEAGOIEAINHIBITIONReactome Database ID Release 759944694Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9944694Reactome DB_ID: 9944691UniProt:F1Q3J3BPIUniProtF1Q3J332EQUAL487EQUAL