BioPAX pathway converted from "SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosol" in the Reactome database.SLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosolSLC34A1,2 cotransports Pi, 3Na+ from extracellular region to cytosolElectrogenic Na+/Pi cotransportThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 1092771extracellular regionGO0005576hydrogenphosphate [ChEBI:43474]hydrogenphosphate[PO3(OH)](2-)HYDROGENPHOSPHATE IONhydrogen phosphate[P(OH)O3](2-)HPO4(2-)phosphateINORGANIC PHOSPHATE GROUPReactomehttp://www.reactome.orgChEBI43474Reactome DB_ID: 741133sodium(1+) [ChEBI:29101]sodium(1+)ChEBI29101Reactome DB_ID: 839103cytosolGO0005829Reactome DB_ID: 293721PHYSIOL-LEFT-TO-RIGHTACTIVATIONConverted from EntitySet in ReactomeReactome DB_ID: 9963429plasma membraneGO0005886SLC34A1,2 [plasma membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntitySLC34A1 [plasma membrane]SLC34A2 [plasma membrane]Canis familiarisNCBI Taxonomy9615UniProtE2R9H6UniProtE2R9H5GO0005436GO molecular functionReactome Database ID Release 759963430Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9963430Reactome Database ID Release 759963432Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9963432ReactomeR-CFA-4276561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-427656.1SLC34A1 encodes Na+/Pi cotransporter (NaPi-IIa) which is expressed in the kidney in the renal proximal tubule (Magagnin et al. 1993). SLC34A2 encodes NaPi-IIb which is abundantly expressed in lung and to a lesser degree in tissues of epithelial origin including small intestine, pancreas, prostate, and kidney (Field et al. 1999). In the lung, SLC34A2 is expressed only in alveolar type II cells, which are responsible for surfactant production, so it is proposed that it uptakes liberated phosphate from the alveolar fluid for surfactant production. Both NaPi-IIa and NaPi-IIb cotransport inorganic phosphate (Pi) with three Na+ ions (electrogenic transport) (Forster et al. 1999, 2002).<br><br>Defects in SLC34A1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 1 (NPHLOP1) (Prie et al. 2002). Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis, a rare disease characterised by the deposition of calcium phosphate microliths throughout the lung (Corut et al. 2006).8327470Pubmed1993Expression cloning of human and rat renal cortex Na/Pi cotransportMagagnin, SWerner, AMarkovich, DSorribas, VStange, GBiber, JMurer, HProc Natl Acad Sci U S A 90:5979-8310198426Pubmed1999Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransportersForster, I CLoo, Donald D FEskandari, SAm. J. Physiol. 276:F644-916960801Pubmed2006Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasisCorut, ASenyigit, AUgur, SAAltin, SOzcelik, UCalisir, HYildirim, ZGocmen, ATolun, AAm J Hum Genet 79:650-612324554Pubmed2002Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporterPrie, DHuart, VBakouh, NPlanelles, GDellis, OGérard, BHulin, PBenqué-Blanchet, FSilve, CGrandchamp, BFriedlander, GN Engl J Med 347:983-9110329428Pubmed1999Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestineFeild, JAZhang, LeiBrun, KABrooks, DPEdwards, RMBiochem Biophys Res Commun 258:578-8212379267Pubmed2002Forging the link between structure and function of electrogenic cotransporters: the renal type IIa Na+/Pi cotransporter as a case studyForster, Ian CKöhler, KatjaBiber, JürgMurer, HeiniProg. Biophys. Mol. Biol. 80:69-108inferred by electronic annotationIEAGOIEA