BioPAX pathway converted from "BH3 only proteins associate with and inactivate anti-apoptotic BCL-XL" in the Reactome database.BH3 only proteins associate with and inactivate anti-apoptotic BCL-XLBH3 only proteins associate with and inactivate anti-apoptotic BCL-XLThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 99672671mitochondrial outer membraneGO0005741UniProt:Q76LT7BCL2L1Reactomehttp://www.reactome.orgCanis familiarisNCBI Taxonomy9615UniProtQ76LT7Chain Coordinates1EQUAL233EQUALConverted from EntitySet in ReactomeReactome DB_ID: 99672631Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityBAD [mitochondrial outer membrane]BID [mitochondrial outer membrane]phospho-BCL2L11 [mitochondrial outer membrane]PMAIP1 [mitochondrial outer membrane]UniProtF1PK10UniProtF1Q0Y3UniProtJ9NWV6UniProtQ1PCT2Reactome DB_ID: 99672691Bcl-XL:BH3-only protein complex [mitochondrial outer membrane]Bcl-XL:BH3-only protein complexReactome DB_ID: 996726711EQUAL233EQUALConverted from EntitySet in ReactomeReactome DB_ID: 99672631Reactome Database ID Release 759967269Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967269ReactomeR-CFA-5081591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-508159.1Reactome Database ID Release 759967271Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9967271ReactomeR-CFA-5081621Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-508162.1BH3-only proteins (tBid, BIM, PUMA, BAD, NOXA) associate with and inactivate anti-apoptotic protein Bcl-XL( Yi et al., 2003; Puthalakath et al., 1999; Nakano and Vousden, 2001; Wang et al., 1999; Oda et al., 2000). The interactions of NOXA with Bcl-XL are inferred from experiments performed in mice (Oda et al., 2000).10198631Pubmed1999The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complexPuthalakath, HHuang, DCO'Reilly, LAKing, SMStrasser, AMol Cell 3:287-9610195903Pubmed1999Ca2+-induced apoptosis through calcineurin dephosphorylation of BADWang, HGPathan, NEthell, IMKrajewski, SYamaguchi, YShibasaki, FMcKeon, FBobo, TFranke, TFReed, JCScience 284:339-4312624108Pubmed2003Inhibition of Bid-induced apoptosis by Bcl-2. tBid insertion, Bax translocation, and Bax/Bak oligomerization suppressedYi, XYin, XMDong, ZJ Biol Chem 278:16992-910807576Pubmed2000Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosisOda, EOhki, RMurasawa, HNemoto, JShibue, TYamashita, TTokino, TTaniguchi, TTanaka, NScience 288:1053-811463392Pubmed2001PUMA, a novel proapoptotic gene, is induced by p53Nakano, KVousden, KHMol Cell 7:683-94inferred by electronic annotationIEAGOIEA