BioPAX pathway converted from "CBL ubiquitinates PI3K" in the Reactome database.CBL ubiquitinates PI3KCBL ubiquitinates PI3KThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Reactome DB_ID: 99687271cytosolGO0005829K48polyUb [cytosol]K48polyUbReactomehttp://www.reactome.orgReactome DB_ID: 99686811FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol]FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3KsReactome DB_ID: 99686791UniProt:F1P861CBLCanis familiarisNCBI Taxonomy9615UniProtF1P861O4'-phospho-L-tyrosine at 731 (in Homo sapiens)731EQUALO4'-phospho-L-tyrosine [MOD:00048]O4'-phospho-L-tyrosine at 700 (in Homo sapiens)700EQUALO4'-phospho-L-tyrosine at 774 (in Homo sapiens)774EQUALChain Coordinates1EQUAL906EQUALConverted from EntitySet in ReactomeReactome DB_ID: 99672891p85-containing Class 1A PI3Ks [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome DB_ID: 99387761UniProt:J9P9Z6GRB2UniProtJ9P9Z61EQUAL217EQUALConverted from EntitySet in ReactomeReactome DB_ID: 99684061FYN-like kinases [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityFYN [cytosol]UniProtE2RC09Reactome Database ID Release 759968681Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9968681ReactomeR-CFA-9126471Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-912647.1Reactome DB_ID: 99687481FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol]FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3KsReactome DB_ID: 99686791O4'-phospho-L-tyrosine at 731 (in Homo sapiens)731EQUALO4'-phospho-L-tyrosine at 700 (in Homo sapiens)700EQUALO4'-phospho-L-tyrosine at 774 (in Homo sapiens)774EQUAL1EQUAL906EQUALReactome DB_ID: 993877611EQUAL217EQUALConverted from EntitySet in ReactomeReactome DB_ID: 99684061Converted from EntitySet in ReactomeReactome DB_ID: 99687461K63polyUb-p85-containing Class 1A PI3Ks [cytosol]Converted from EntitySet in Reactome. Each synonym is a name of a PhysicalEntity, and each XREF points to one PhysicalEntityReactome Database ID Release 759968748Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9968748ReactomeR-CFA-9127991Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-912799.1Reactome Database ID Release 759968750Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9968750ReactomeR-CFA-9126271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-912627.1Cbl is an E3 ubiquitin-protein ligase that negatively regulates signaling pathways by targeting proteins for ubiquitination and proteasomal degradation (Rao et al. 2002). Cbl-B targets PI3K for ubiquitination and degradation in T cells (Fang et al. 2000). Similarly, Cbl activation by tyrosine phosphorylation increases PI3K ubiquitination and proteasomal degradation (Dufour et al. 2008).11087752Pubmed2001Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cellsFang, DWang, HYFang, NAltman, YElly, CLiu, YCJ Biol Chem 276:4872-811994499Pubmed2002The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune systemRao, NDodge, IBand, HJ Leukoc Biol 71:753-6318374639Pubmed2008FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survivalDufour, CGuenou, HKaabeche, KBouvard, DSanjay, AMarie, PJBone 42:1032-9inferred by electronic annotationIEAGOIEA