BioPAX pathway converted from "GGPS1 hexamer transfers IPPP to DMAPP" in the Reactome database. 2.5.1.1 GGPS1 hexamer transfers IPPP to DMAPP GGPS1 hexamer transfers IPPP to DMAPP Addition of isopentenyl pyrophosphate to DMAPP This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Reactome DB_ID: 191362 1 cytosol GO 0005829 isopentenyl diphosphate [ChEBI:16584] isopentenyl diphosphate Reactome http://www.reactome.org ChEBI 16584 Reactome DB_ID: 191324 1 prenyl diphosphate [ChEBI:16057] prenyl diphosphate ChEBI 16057 Reactome DB_ID: 191409 1 geranyl diphosphate [ChEBI:17211] geranyl diphosphate ChEBI 17211 Reactome DB_ID: 111294 1 diphosphate(3-) [ChEBI:33019] diphosphate(3-) ChEBI 33019 PHYSIOL-LEFT-TO-RIGHT ACTIVATION Reactome DB_ID: 9991333 holo-GGPS1 hexamer [cytosol] holo-GGPS1 hexamer Reactome DB_ID: 9991331 6 GGPS1:3Mg2+ [cytosol] GGPS1:3Mg2+ Reactome DB_ID: 29926 3 magnesium(2+) [ChEBI:18420] magnesium(2+) ChEBI 18420 Reactome DB_ID: 9991329 1 UniProt:Q6F596 Ggps1 Rattus norvegicus NCBI Taxonomy 10116 UniProt Q6F596 Chain Coordinates 1 EQUAL 300 EQUAL Reactome Database ID Release 81 9991331 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991331 Reactome R-RNO-981557 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-981557.1 Reactome Database ID Release 81 9991333 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991333 Reactome R-RNO-981569 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-981569.1 GO 0004161 GO molecular function Reactome Database ID Release 81 9991337 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991337 Reactome Database ID Release 81 9991339 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9991339 Reactome R-RNO-9717834 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-9717834.1 The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021). 16684881 Pubmed 2006 The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs Kavanagh, KL Guo, K Dunford, JE Wu, X Knapp, S Ebetino, FH Rogers, MJ Russell, RG Oppermann, U Proc Natl Acad Sci U S A 103:7829-34 10026212 Pubmed 1999 Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. Kuzuguchi, T Morita, Y Sagami, I Sagami, H Ogura, K J Biol Chem 274:5888-94 9741684 Pubmed 1998 Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression Ericsson, J Greene, JM Carter, KC Shell, BK Duan, DR Florence, C Edwards, PA J Lipid Res 39:1731-9 33246356 Pubmed 2021 Structure, catalysis, and inhibition mechanism of prenyltransferase Chang, Hsin-Yang Cheng, Tien-Hsing Wang, Andrew H-J IUBMB Life 73:40-63 inferred by electronic annotation IEA GO IEA