BioPAX pathway converted from "KTN1 binds Kinesin-1" in the Reactome database.LEFT-TO-RIGHTKTN1 binds Kinesin-1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>Kinesin-1Reactome DB_ID: 9972759cytosolGENE ONTOLOGYGO:0005829Converted from EntitySet in ReactomeKLC1,KLC2,KLC3,KLC4Kinesin-1 light chainsReactome DB_ID: 9972747KLC1KLC1E2RAF0Reactome DB_ID: 9972733UniProt:E2RAF0KLC1Canis familiarisNCBI Taxonomy9615UniProtE2RAF01EQUAL573EQUALReactome Database ID Release 759972733Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972733ReactomeR-CFA-9832841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983284.1Reactomehttp://www.reactome.orgKLC2KLC2E2RGH8Reactome DB_ID: 9972737UniProt:E2RGH8KLC2UniProtE2RGH81EQUAL622EQUALReactome Database ID Release 759972737Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972737ReactomeR-CFA-9831911Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983191.1KLC3KLC3E2RN88Reactome DB_ID: 9972741UniProt:E2RN88KLC3UniProtE2RN881EQUAL504EQUALReactome Database ID Release 759972741Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972741ReactomeR-CFA-9832321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983232.1KLC4KLC4E2RCD4Reactome DB_ID: 9972745UniProt:E2RCD4KLC4UniProtE2RCD41EQUAL619EQUALReactome Database ID Release 759972745Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972745ReactomeR-CFA-9832441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983244.1Reactome Database ID Release 759972747Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972747ReactomeR-CFA-9832261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983226.12Converted from EntitySet in ReactomeKinesin-1 heavy chainReactome DB_ID: 9972757KIF5AKIF5AE2QYY9Reactome DB_ID: 9972751UniProt:E2QYY9KIF5AUniProtE2QYY92EQUAL1032EQUALReactome Database ID Release 759972751Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972751ReactomeR-CFA-9831901Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983190.1KIF5BKIF5BE2QTN0Reactome DB_ID: 9972755UniProt:E2QTN0KIF5BUniProtE2QTN02EQUAL963EQUALReactome Database ID Release 759972755Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972755ReactomeR-CFA-2651811Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-265181.1Reactome Database ID Release 759972757Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972757ReactomeR-CFA-9832111Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983211.12Reactome Database ID Release 759972759Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9972759ReactomeR-CFA-9832271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-983227.1RHOA,RHOG,RAC1,CDC42:GTP:KTN1Reactome DB_ID: 9999136endoplasmic reticulum membraneGENE ONTOLOGYGO:0005789RHOA,RHOG,RAC1,CDC42:GTPReactome DB_ID: 9999128GTPGuanosine 5'-triphosphateReactome DB_ID: 29438GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 7529438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438ReactomeR-ALL-294383Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.3COMPOUNDC00044additional informationMIMI:03611Converted from EntitySet in ReactomeRHOA,RHOG,RAC1,CDC42Reactome DB_ID: 9999126CDC42CDC42P60952Reactome DB_ID: 9999120UniProt:P60952CDC42UniProtP609521EQUAL188EQUALReactome Database ID Release 759999120Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999120ReactomeR-CFA-56720861Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5672086.1RHOARHOAF6XY66Reactome DB_ID: 9999122UniProt:F6XY66RHOAUniProtF6XY661EQUAL190EQUALReactome Database ID Release 759999122Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999122ReactomeR-CFA-56720821Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5672082.1RHOGRHOGE2R020Reactome DB_ID: 9999124UniProt:E2R020RHOGUniProtE2R0201EQUAL188EQUALReactome Database ID Release 759999124Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999124ReactomeR-CFA-56720841Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5672084.1Reactome Database ID Release 759999126Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999126ReactomeR-CFA-56259651Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5625965.11Reactome Database ID Release 759999128Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999128ReactomeR-CFA-56259641Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5625964.11KTN1Reactome DB_ID: 9999134KTN1KTN1E2RG59Reactome DB_ID: 9999132UniProt:E2RG59KTN1UniProtE2RG591EQUAL1357EQUALReactome Database ID Release 759999132Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999132ReactomeR-CFA-2016041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-201604.12Reactome Database ID Release 759999134Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999134ReactomeR-CFA-56721031Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5672103.11Reactome Database ID Release 759999136Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9999136ReactomeR-CFA-56259551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5625955.1RHOA,RHOG,RAC1,CDC42:GTP:KTN1:Kinesin-1Reactome DB_ID: 1000139211Reactome Database ID Release 7510001392Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10001392ReactomeR-CFA-56720871Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5672087.1Reactome Database ID Release 7510001394Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10001394ReactomeR-CFA-56720831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5672083.1The C-terminal region of KTN1 (kinectin) binds the cargo-binding tail of the kinesin heavy chain KIF5A and enhances microtubule-stimulated ATPase activity of KIF5A. KIF5A is a part of the conventional kinesin complex, kinesin-1. RHO GTPases, KTN1 and kinesin-1 colocalize on endoplasmic reticulum (ER) membranes and ER-derived vesicles and are thought to be involved in organelle/vesicle motility (Ong et al. 2000, Vignal et al. 2001)11689693Pubmed2001Kinectin is a key effector of RhoG microtubule-dependent cellular activityVignal, EBlangy, AMartin, MGauthier-Rouvière, CFort, PMol. Cell. Biol. 21:8022-3410913441Pubmed2000Kinectin-kinesin binding domains and their effects on organelle motilityOng, L LLim, A PEr, C PKuznetsov, S AYu, HJ. Biol. Chem. 275:32854-60inferred from electronic annotationEVIDENCE CODEECO:0000203