BioPAX pathway converted from "SIRT5 deacetylates Cytochrome C" in the Reactome database.LEFT-TO-RIGHTSIRT5 deacetylates Cytochrome CThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>NADNAD+NAD(+)Nicotinamide adenine dinucleotideDPNDiphosphopyridine nucleotideNAD+ Reactome DB_ID: 5688282mitochondrial intermembrane spaceGENE ONTOLOGYGO:0005758NAD(1-) [ChEBI:57540]NAD(1-)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD(+)NAD anionChEBICHEBI:57540Reactome Database ID Release 755688282Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5688282ReactomeR-ALL-56882824Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5688282.4Reactomehttp://www.reactome.orgCOMPOUNDC00003additional informationMIMI:0361CYCSAcK-CYCSP00011Reactome DB_ID: 10003540UniProt:P00011CYCSCanis familiarisNCBI Taxonomy9615UniProtP00011N6-acetyl-L-lysineMODMOD:000642EQUAL105EQUALReactome Database ID Release 7510003540Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003540ReactomeR-CFA-56883081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5688308.1NAMnicotinamideReactome DB_ID: 5688281nicotinamide [ChEBI:17154]nicotinamideChEBICHEBI:17154Reactome Database ID Release 755688281Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5688281ReactomeR-ALL-56882813Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5688281.3COMPOUNDC001532'-O-acetyl-ADP-ribose2'-O-acetyl adenosine-5-diphosphoribose2''-O-acetyl-ADP-D-riboseReactome DB_ID: 56883402''-O-acetyl-ADP-D-ribose [ChEBI:76279]2''-O-acetyl-ADP-D-riboseChEBICHEBI:76279Reactome Database ID Release 755688340Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=5688340ReactomeR-ALL-56883403Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-5688340.3CYCSCYCSP00011Reactome DB_ID: 99419192EQUAL105EQUALReactome Database ID Release 759941919Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9941919ReactomeR-CFA-1142441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-114244.1ACTIVATIONactiveUnit: #Protein3SIRT5:Zn2+Reactome DB_ID: 10003546Zn2+Zn++zinc(2+)Zinc ionZn(II)Reactome DB_ID: 3777117zinc(2+) [ChEBI:29105]zinc(2+)ChEBICHEBI:29105Reactome Database ID Release 753777117Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3777117ReactomeR-ALL-37771173Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3777117.3COMPOUNDC000381SIRT5SIRT5E2RDZ6Reactome DB_ID: 10003544mitochondrial matrixGENE ONTOLOGYGO:0005759UniProt:E2RDZ6SIRT5UniProtE2RDZ637EQUAL310EQUALReactome Database ID Release 7510003544Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003544ReactomeR-CFA-56877781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5687778.11Reactome Database ID Release 7510003546Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003546ReactomeR-CFA-56882881Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5688288.1GENE ONTOLOGYGO:0034979gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510003547Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003547Reactome Database ID Release 7510003549Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10003549ReactomeR-CFA-56882941Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-5688294.1Sirtuin 5 has been shown to deacetylate Cytochrome C in the the mitochondrial intermembrane space (Schlicker et al. 2008). The functional significance of this is unknown (Bao & Sack 2010).20680393Pubmed2010Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressorsBao, JianjunSack, Michael NCell. Mol. Life Sci. 67:3073-8718680753Pubmed2008Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5Schlicker, ChristineGertz, MelaniePapatheodorou, PanagiotisKachholz, BarbaraBecker, Christian F WSteegborn, ClemensJ. Mol. Biol. 382:790-801inferred from electronic annotationEVIDENCE CODEECO:0000203