BioPAX pathway converted from "Envoplakin binds periplakin" in the Reactome database. LEFT-TO-RIGHT Envoplakin binds periplakin This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Ppl PPL D4A5T8 Reactome DB_ID: 10015804 cytosol GENE ONTOLOGY GO:0005829 UniProt:D4A5T8 Ppl Rattus norvegicus NCBI Taxonomy 10116 UniProt D4A5T8 1 EQUAL 1756 EQUAL Reactome Database ID Release 82 10015804 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015804 Reactome R-RNO-6810850 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-6810850.1 Reactome http://www.reactome.org Evpl EVPL G3V765 Reactome DB_ID: 10015800 UniProt:G3V765 Evpl UniProt G3V765 1 EQUAL 2033 EQUAL Reactome Database ID Release 82 10015800 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015800 Reactome R-RNO-6810853 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-6810853.1 EVPL:PPL Reactome DB_ID: 10015806 1 1 Reactome Database ID Release 82 10015806 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015806 Reactome R-RNO-6814178 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-6814178.1 Reactome Database ID Release 82 10015808 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10015808 Reactome R-RNO-6810843 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-RNO-6810843.1 Envoplakin (EVPL) is insoluble under physiological conditions but soluble as a heterodimer with periplakin (PPL) (Kalinin et al. 2004). The heterodimers provide a firm but flexible structures (Al-Jassar et al. 2013). EVPL and PPL deposition and crosslinking are amongst the earliest events of cornification (Kalinin et al. 2002, Candi et al. 2005). They partially colocalize with desmosomal proteins and keratin intermediate filaments (Ruhrberg et al. 1996, DiColandrea et al. 2000), linking the cornified envelope to desmosomes and keratin filaments (Ruhrberg et al. 1996, 1997). PPL also associates with cortical actin at the interdesmosomal plasma membrane (DiColandrea et al. 2000, Groot et al. 2004). 9412476 Pubmed 1997 Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin Ruhrberg, C Hajibagheri, M A Parry, D A Watt, F M J. Cell Biol. 139:1835-49 12210515 Pubmed 2002 Epithelial barrier function: assembly and structural features of the cornified cell envelope Kalinin, Andrey E Kajava, Andrey V Steinert, Peter M Bioessays 24:789-800 23922795 Pubmed 2013 Hinged plakin domains provide specialized degrees of articulation in envoplakin, periplakin and desmoplakin Al-Jassar, Caezar Bernadό, Pau Chidgey, Martyn Overduin, Michael PLoS ONE 8:e69767 11062259 Pubmed 2000 Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope DiColandrea, T Karashima, T Määttä, A Watt, F M J. Cell Biol. 151:573-86 8707850 Pubmed 1996 Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin Ruhrberg, C Hajibagheri, M A Simon, M Dooley, T P Watt, F M J. Cell Biol. 134:715-29 15033990 Pubmed 2004 Co-assembly of envoplakin and periplakin into oligomers and Ca(2+)-dependent vesicle binding: implications for cornified cell envelope formation in stratified squamous epithelia Kalinin, Andrey E Idler, William W Marekov, Lyuben N McPhie, P Bowers, Blair Steinert, Peter M Steven, Alasdair C J. Biol. Chem. 279:22773-80 15803139 Pubmed 2005 The cornified envelope: a model of cell death in the skin Candi, Eleonora Schmidt, Rainer Melino, Gerry Nat. Rev. Mol. Cell Biol. 6:328-40 15337775 Pubmed 2004 Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane Groot, Karen R Sevilla, Lisa M Nishi, Kazunori DiColandrea, Teresa Watt, Fiona M J. Cell Biol. 166:653-9 inferred from electronic annotation EVIDENCE CODE ECO:0000203