BioPAX pathway converted from "ANKLE2 is deacetylated by SIRT2" in the Reactome database.LEFT-TO-RIGHTANKLE2 is deacetylated by SIRT2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>ANKLE2Ac-K302-ANKLE2E2R7S4Reactome DB_ID: 10026199endoplasmic reticulum membraneGENE ONTOLOGYGO:0005789UniProt:E2R7S4ANKLE2Canis familiarisNCBI Taxonomy9615UniProtE2R7S4302EQUALN6-acetyl-L-lysineMODMOD:000641EQUAL938EQUALReactome Database ID Release 7510026199Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10026199ReactomeR-CFA-96679461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-9667946.1Reactomehttp://www.reactome.orgNADNAD+NAD(+)Nicotinamide adenine dinucleotideDPNDiphosphopyridine nucleotideReactome DB_ID: 29360cytosolGENE ONTOLOGYGO:0005829NAD(1-) [ChEBI:57540]NAD(1-)adenosine 5'-{3-[1-(3-carbamoylpyridinio)-1,4-anhydro-D-ribitol-5-yl] diphosphate}NAD(+)NAD anionChEBICHEBI:57540Reactome Database ID Release 7529360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29360ReactomeR-ALL-293605Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29360.5COMPOUNDC00003additional informationMIMI:0361H2OwaterReactome DB_ID: 29356water [ChEBI:15377]waterChEBICHEBI:15377Reactome Database ID Release 7529356Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356ReactomeR-ALL-293565Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5COMPOUNDC00001ANKLE2ANKLE2E2R7S4Reactome DB_ID: 99887661EQUAL938EQUALReactome Database ID Release 759988766Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9988766ReactomeR-CFA-25290001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2529000.1NAMnicotinamideReactome DB_ID: 197277nicotinamide [ChEBI:17154]nicotinamideChEBICHEBI:17154Reactome Database ID Release 75197277Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=197277ReactomeR-ALL-1972773Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-197277.3COMPOUNDC001532'-O-acetyl-ADP-ribose2'-O-acetyl adenosine-5-diphosphoribose2''-O-acetyl-ADP-D-riboseReactome DB_ID: 96679562''-O-acetyl-ADP-D-ribose [ChEBI:76279]2''-O-acetyl-ADP-D-riboseChEBICHEBI:76279Reactome Database ID Release 759667956Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=9667956ReactomeR-ALL-96679561Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-9667956.1ACTIVATIONSIRT2SIRT2F1PTX2Reactome DB_ID: 10026203UniProt:F1PTX2SIRT2UniProtF1PTX22EQUAL389EQUALReactome Database ID Release 7510026203Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10026203ReactomeR-CFA-21611181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-2161118.1GENE ONTOLOGYGO:0034979gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510026204Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10026204Reactome Database ID Release 7510026206Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10026206ReactomeR-CFA-96679521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-9667952.1ANKLE2 (LEM4) is required for normal nuclear envelope (NE) formation at the end of mitosis (Ascencio et al. 2012, Kaufmann et al. 2016). Deacetylation of ANKLE2 on residue K302 by SIRT2 promotes this process (Kaufman et al. 2016).22770216Pubmed2012Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosisAsencio, ClaudioDavidson, Iain FSantarella-Mellwig, RachelLy-Hartig, Thi Bach NgaMall, MoritzWallenfang, Matthew RMattaj, Iain WGorjánácz, MátyásCell 150:122-3527875273Pubmed2016SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylationKaufmann, TanjaKukolj, EvaBrachner, AndreasBeltzung, EtienneBruno, MelaniaKostrhon, SebastianOpravil, SusanneHudecz, OttoMechtler, KarlWarren, GrahamSlade, DeaJ. Cell. Sci. 129:4607-4621inferred from electronic annotationEVIDENCE CODEECO:0000203