BioPAX pathway converted from "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2" in the Reactome database.LEFT-TO-RIGHT1.3.8.4isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>FADFlavin adenine dinucleotideReactome DB_ID: 113596mitochondrial matrixGENE ONTOLOGYGO:0005759FAD [ChEBI:16238]FADFlavin adenine dinucleotideChEBICHEBI:16238Reactome Database ID Release 75113596Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=113596ReactomeR-ALL-1135962Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-113596.2Reactomehttp://www.reactome.orgCOMPOUNDC00016additional informationMIMI:0361ISV-CoA3-methylbutanoyl-CoAisovaleryl-CoAReactome DB_ID: 70715isovaleryl-CoA [ChEBI:15487]isovaleryl-CoAChEBICHEBI:15487Reactome Database ID Release 7570715Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70715ReactomeR-ALL-707153Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70715.3COMPOUNDC02939bMC-CoAbeta-methylcrotonyl-CoA3-methylbut-2-enoyl-CoAReactome DB_ID: 707443-methylbut-2-enoyl-CoA [ChEBI:15486]3-methylbut-2-enoyl-CoAChEBICHEBI:15486Reactome Database ID Release 7570744Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70744ReactomeR-ALL-707443Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70744.3COMPOUNDC03069FADH2Reactome DB_ID: 31649FADH2 [ChEBI:17877]FADH2ChEBICHEBI:17877Reactome Database ID Release 7531649Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=31649ReactomeR-ALL-316492Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-31649.2COMPOUNDC01352ACTIVATIONIVD tetramerReactome DB_ID: 100307594IVDA0A452DI40Reactome DB_ID: 10030757UniProt:A0A452DI40Bos taurusNCBI Taxonomy9913UniProtA0A452DI4030EQUAL423EQUALReactome Database ID Release 7510030757Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030757ReactomeR-BTA-707291Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-70729.14Reactome Database ID Release 7510030759Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030759ReactomeR-BTA-707301Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-70730.1GENE ONTOLOGYGO:0008470gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510030760Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030760Reactome Database ID Release 7510030762Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030762ReactomeR-BTA-707451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-70745.1Mitochondrial isovaleryl dehydrogenase (IVD) catalyzes the reaction of isovaleryl-CoA and FAD to form beta-methylcrotonyl-CoA and FADH2 (Finocchiaro et al. 1978; Rhead and Tanaka 1980). Crystallographic studies demonstrated the existene of a tetramer of IVD polypeptides lacking an aminoterminal mitochondrial targeting sequence (Tiffany et al. 1997).9214289Pubmed1997Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.Tiffany, KARoberts, DLWang, MPaschke, RMohsen, AWVockley, JKim, Jung-Ja PBiochemistry 36:8455-643597357Pubmed1987Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver.Finocchiaro, GIto, MTanaka, KJ Biol Chem 262:7982-96928646Pubmed1980Demonstration of a specific mitochondrial isovaleryl-CoA dehydrogenase deficiency in fibroblasts from patients with isovaleric acidemia.Rhead, WJTanaka, KProc Natl Acad Sci U S A 77:580-3inferred from electronic annotationEVIDENCE CODEECO:0000203