BioPAX pathway converted from "MADCAM1-1 binds Integrin alpha4beta7" in the Reactome database.LEFT-TO-RIGHTMADCAM1-1 binds Integrin alpha4beta7This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>MADCAM1MADCAM1-1A0A3Q1MBF2Reactome DB_ID: 10039431plasma membraneGENE ONTOLOGYGO:0005886UniProt:A0A3Q1MBF2MADCAM1Bos taurusNCBI Taxonomy9913UniProtA0A3Q1MBF219EQUAL406EQUALReactome Database ID Release 7510039431Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039431ReactomeR-BTA-1980951Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198095.1Reactomehttp://www.reactome.org2Integrin alpha4beta7Reactome DB_ID: 10039427ITGB7ITGB7F6RKH9Reactome DB_ID: 10039425UniProt:F6RKH9ITGB7UniProtF6RKH920EQUAL798EQUALReactome Database ID Release 7510039425Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039425ReactomeR-BTA-30064271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-3006427.11ITGA4ITGA4F1MEF6Reactome DB_ID: 10039421UniProt:F1MEF6ITGA4UniProtF1MEF634EQUAL1032EQUALReactome Database ID Release 7510039421Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039421ReactomeR-BTA-1980071Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198007.11Reactome Database ID Release 7510039427Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039427ReactomeR-BTA-1989271Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198927.1Integrin alpha4beta7:MADCAM1Reactome DB_ID: 1003943321Reactome Database ID Release 7510039433Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039433ReactomeR-BTA-1989251Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-198925.1Reactome Database ID Release 7510039435Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10039435ReactomeR-BTA-1990321Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-199032.1Mucosal addressin cell adhesion molecule (MADCAM1) is present in the endothelium of mucosa, and binds alpha-4 beta-7 integrin and L-selectin, regulating both the passage and retention of leukocytes in mucosal tissues. MADCAM1 has been shown to be present as a homodimer.11807247Pubmed2002A reassessment of the MAdCAM-1 structure and its role in integrin recognitionDando, JWilkinson, KWOrtlepp, SKing, DJBrady, RLActa Crystallogr D Biol Crystallogr 58:233-419700512Pubmed1998Structural specializations of immunoglobulin superfamily members for adhesion to integrins and virusesWang, JSpringer, TAImmunol Rev 163:197-215inferred from electronic annotationEVIDENCE CODEECO:0000203