BioPAX pathway converted from "NOX3 complex:RAC1:GTP generates superoxide from oxygen" in the Reactome database.LEFT-TO-RIGHT1.6.3NOX3 complex:RAC1:GTP generates superoxide from oxygenThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TPNHNADPHReactome DB_ID: 29364cytosolGENE ONTOLOGYGO:0005829NADPH [ChEBI:16474]NADPHTPNHChEBICHEBI:16474Reactome Database ID Release 7529364Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29364ReactomeR-ALL-293642Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29364.2Reactomehttp://www.reactome.orgCOMPOUNDC00005additional informationMIMI:0361O2OxygendioxygenReactome DB_ID: 352327extracellular regionGENE ONTOLOGYGO:0005576dioxygen [ChEBI:15379]dioxygenChEBICHEBI:15379Reactome Database ID Release 75352327Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=352327ReactomeR-ALL-3523273Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-352327.3COMPOUNDC000072TPNNADP+NADPNADP(+)Nicotinamide adenine dinucleotide phosphatebeta-Nicotinamide adenine dinucleotide phosphateTriphosphopyridine nucleotideReactome DB_ID: 29366NADP(+) [ChEBI:18009]NADP(+)ChEBICHEBI:18009Reactome Database ID Release 7529366Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29366ReactomeR-ALL-293663Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29366.3COMPOUNDC00006O2.-SO2.-superoxideReactome DB_ID: 3299686superoxide [ChEBI:18421]superoxideO2-O2.-ChEBICHEBI:18421Reactome Database ID Release 753299686Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=3299686ReactomeR-ALL-32996863Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-3299686.32H+protonhydronReactome DB_ID: 70106hydron [ChEBI:15378]hydronChEBICHEBI:15378Reactome Database ID Release 7570106Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70106ReactomeR-ALL-701064Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70106.4COMPOUNDC00080ACTIVATIONNOX3 complex:RAC1:GTPReactome DB_ID: 10071098plasma membraneGENE ONTOLOGYGO:0005886NOX3 ComplexReactome DB_ID: 10071096CYBACYBAO46521Reactome DB_ID: 10068134UniProt:O46521CYBABos taurusNCBI Taxonomy9913UniProtO465212EQUAL195EQUALReactome Database ID Release 7510068134Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10068134ReactomeR-BTA-52187441Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5218744.11NOX3NOX3E1BFF3Reactome DB_ID: 10071094UniProt:E1BFF3NOX3UniProtE1BFF31EQUAL568EQUALReactome Database ID Release 7510071094Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10071094ReactomeR-BTA-56687281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5668728.11NCF1A0A452DHY1Reactome DB_ID: 10053531UniProt:A0A452DHY1UniProtA0A452DHY11EQUAL390EQUALReactome Database ID Release 7510053531Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10053531ReactomeR-BTA-12222961Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1222296.11NCF2NCF2A0A3Q1MTW8Reactome DB_ID: 10053535UniProt:A0A3Q1MTW8NCF2UniProtA0A3Q1MTW81EQUAL526EQUALReactome Database ID Release 7510053535Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10053535ReactomeR-BTA-12226001Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1222600.11Reactome Database ID Release 7510071096Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10071096ReactomeR-BTA-56687341Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5668734.11RAC1:GTPReactome DB_ID: 10044653GTPGuanosine 5'-triphosphateReactome DB_ID: 29438GTP [ChEBI:15996]GTPGuanosine 5'-triphosphateChEBICHEBI:15996Reactome Database ID Release 7529438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29438ReactomeR-ALL-294383Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29438.3COMPOUNDC000441Ghost homologue of RAC1Reactome DB_ID: 10044651Reactome Database ID Release 7510044651Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10044651ReactomeR-BTA-3511411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-351141.11Reactome Database ID Release 7510044653Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10044653ReactomeR-BTA-4426411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-442641.11Reactome Database ID Release 7510071098Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10071098ReactomeR-BTA-56687381Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5668738.1GENE ONTOLOGYGO:0016175gene ontology term for cellular functionMIMI:0355Same Catalyst ActivityReactome Database ID Release 7510071099Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10071099Reactome Database ID Release 7510071101Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10071101ReactomeR-BTA-56687311Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5668731.1While NOX3:CYBA complex has constitutive NADPH oxidase activity, the presence of NCF1, NCF2 or NOXA1 and RAC1:GTP enhances the production of superoxide O2- by the NOX3:CYBA complex. When NCF1 is replaced with NOXO1, RAC1:GTP becomes dispensible for the full activation of the NOX3 complex (Ueno et al. 2005, Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008)15824103Pubmed2005The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activatorsUeno, NorikoTakeya, RyuMiyano, KeiKikuchi, HideakiSumimoto, HidekiJ. Biol. Chem. 280:23328-3916507994Pubmed2006Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidasesUeyama, TakehikoGeiszt, MiklósLeto, Thomas LMol. Cell. Biol. 26:2160-7417583407Pubmed2007Role of the small GTPase Rac in p22phox-dependent NADPH oxidasesMiyano, KeiSumimoto, HidekiBiochimie 89:1133-4418347018Pubmed2008Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanismKao, Yu-YaGianni, DavideBohl, BenjaminTaylor, Ross MBokoch, Gary MJ. Biol. Chem. 283:12736-46inferred from electronic annotationEVIDENCE CODEECO:0000203