BioPAX pathway converted from "CDK-mediated phosphorylation and removal of Cdc6" in the Reactome database.CDK-mediated phosphorylation and removal of Cdc6This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTPhosphorylated Cdc6 is exported from the nucleusThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>A0A3Q1MVB0phospho-p-CDC6Reactome DB_ID: 10030434nucleoplasmGENE ONTOLOGYGO:0005654UniProt:A0A3Q1MVB0Bos taurusNCBI Taxonomy9913UniProtA0A3Q1MVB0phosphorylated residueMODMOD:006961EQUAL560EQUALReactome Database ID Release 7510030434Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030434ReactomeR-BTA-56613171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-5661317.1Reactomehttp://www.reactome.orgA0A3Q1MVB0phospho-p-CDC6Reactome DB_ID: 10030436cytosolGENE ONTOLOGYGO:00058291EQUAL560EQUALReactome Database ID Release 7510030436Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030436ReactomeR-BTA-685831Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-68583.1Reactome Database ID Release 7510030438Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10030438ReactomeR-BTA-690061Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-69006.1In this reaction, 1 molecule of 'phosphorylated Cdc6' is translocated from nucleoplasm to cytosol.<br><br>This movement of the molecule occurs through the 'nuclear pore'.<br>10339564Pubmed1999Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6.Jiang, WWells, NJHunter, TonyProc Natl Acad Sci U S A 96:6193-8inferred from electronic annotationEVIDENCE CODEECO:0000203Reactome Database ID Release 7510088003Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10088003ReactomeR-BTA-690171Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-69017.1As cells enter S phase, HsCdc6p is phosphorylated by CDK promoting its export from the nucleus (see Bell and Dutta 2002). 12045100Pubmed2002DNA replication in eukaryotic cells.Bell, SPDutta, AAnnu Rev Biochem 71:333-7411046155Pubmed2000Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis.Mendez, JStillman, BMol Cell Biol 20:8602-12