BioPAX pathway converted from "RNA Polymerase II Transcription Pre-Initiation And Promoter Opening" in the Reactome database.RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTRecognition and Binding of Core Promoter Elements by TFIIDThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>TFIIDReactome DB_ID: 10033384nucleoplasmGENE ONTOLOGYGO:0005654TAF6A0A3Q1MS65Reactome DB_ID: 10033354UniProt:A0A3Q1MS65Bos taurusNCBI Taxonomy9913UniProtA0A3Q1MS651EQUAL677EQUALReactome Database ID Release 7510033354Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033354ReactomeR-BTA-655451Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65545.1Reactomehttp://www.reactome.org1Converted from EntitySet in ReactomeHomologues of TAF13Reactome DB_ID: 10033338TAF13TAF13A0A3Q1MA78Reactome DB_ID: 10033332UniProt:A0A3Q1MA78TAF13UniProtA0A3Q1MA781EQUAL124EQUALReactome Database ID Release 7510033332Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033332ReactomeR-BTA-655571Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65557.1TAF13TAF13Q148M7Reactome DB_ID: 10033336UniProt:Q148M7TAF13UniProtQ148M71EQUAL124EQUALReactome Database ID Release 7510033336Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033336ReactomeR-BTA-65557-21Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65557-2.1Reactome Database ID Release 7510033338Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033338ReactomeR-BTA-65557-31Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65557-3.11TAF3TAF3E1BIA9Reactome DB_ID: 10033364UniProt:E1BIA9TAF3UniProtE1BIA91EQUAL929EQUALReactome Database ID Release 7510033364Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033364ReactomeR-BTA-2124461Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-212446.11Ghost homologue of TAF4Reactome DB_ID: 10033328Reactome Database ID Release 7510033328Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033328ReactomeR-BTA-655411Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65541.11TBPF1MKV5Reactome DB_ID: 10032262UniProt:F1MKV5UniProtF1MKV51EQUAL339EQUALReactome Database ID Release 7510032262Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10032262ReactomeR-BTA-837181Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-83718.11TAF10TAF10A5PJW1Reactome DB_ID: 10033350UniProt:A5PJW1TAF10UniProtA5PJW11EQUAL218EQUALReactome Database ID Release 7510033350Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033350ReactomeR-BTA-655511Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65551.11TAF9TAF9Q17QQ4Reactome DB_ID: 10033358UniProt:Q17QQ4TAF9UniProtQ17QQ41EQUAL264EQUALReactome Database ID Release 7510033358Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033358ReactomeR-BTA-2124521Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-212452.11TAF5TAF5E1BEN8Reactome DB_ID: 10033322UniProt:E1BEN8TAF5UniProtE1BEN81EQUAL800EQUALReactome Database ID Release 7510033322Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033322ReactomeR-BTA-655431Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65543.11Ghost homologue of TAF9BReactome DB_ID: 10033366Reactome Database ID Release 7510033366Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033366ReactomeR-BTA-2124041Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-212404.11TAF15TAF15E1BGX1Reactome DB_ID: 10033382UniProt:E1BGX1TAF15UniProtE1BGX11EQUAL592EQUALReactome Database ID Release 7510033382Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033382ReactomeR-BTA-90206801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-9020680.11Ghost homologue of TAF2Reactome DB_ID: 10033360Reactome Database ID Release 7510033360Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033360ReactomeR-BTA-2124081Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-212408.11TAF1TAF1A0A3Q1MEP0Reactome DB_ID: 10033370UniProt:A0A3Q1MEP0TAF1UniProtA0A3Q1MEP01EQUAL1872EQUALReactome Database ID Release 7510033370Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033370ReactomeR-BTA-655391Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65539.11Converted from EntitySet in ReactomeTAF7,TAF7LReactome DB_ID: 10033378TAF7LTAF7LG3N1E6Reactome DB_ID: 10033376UniProt:G3N1E6TAF7LUniProtG3N1E61EQUAL462EQUALReactome Database ID Release 7510033376Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033376ReactomeR-BTA-29808741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2980874.1Reactome Database ID Release 7510033378Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033378ReactomeR-BTA-88667021Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8866702.11TAF12TAF12Q3T174Reactome DB_ID: 10033342UniProt:Q3T174TAF12UniProtQ3T1741EQUAL161EQUALReactome Database ID Release 7510033342Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033342ReactomeR-BTA-655551Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65555.11TAF4BTAF4BE1BGK7Reactome DB_ID: 10033326UniProt:E1BGK7TAF4BUniProtE1BGK71EQUAL862EQUALReactome Database ID Release 7510033326Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033326ReactomeR-BTA-655591Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65559.11TAF11TAF11Q3ZBP7Reactome DB_ID: 10033346UniProt:Q3ZBP7TAF11UniProtQ3ZBP71EQUAL211EQUALReactome Database ID Release 7510033346Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033346ReactomeR-BTA-655531Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-65553.11Reactome Database ID Release 7510033384Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033384ReactomeR-BTA-1096261Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109626.1DNA containing RNA Polymerase II promoterReactome DB_ID: 109627Reactome Database ID Release 75109627Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=109627ReactomeR-ALL-1096272Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-109627.2ChEBI61120additional informationMIMI:0361pol II promoter:TFIID complexReactome DB_ID: 1003338611Reactome Database ID Release 7510033386Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033386ReactomeR-BTA-1096281Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109628.1Reactome Database ID Release 7510033388Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10033388ReactomeR-BTA-1096361Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-109636.1Although TBP (TATA box binding factor) is necessary and sufficient for initiation of basal transcription, the other subunits of the general transcription factor TFIID, the TBP-associated factors, are required for response to transcriptional activators. TBP binds to the TATA box (a core promoter element), and bends the DNA 80 degrees toward the major groove. This conformation of TBP-TATA box provides the proper topology for the binding of the general transcription factor TFIIB.<p>Transcriptional activators function by affecting the kinetics of binding of TBP to the promoter DNA.8330735Pubmed1993TBP, a universal eukaryotic transcription factor?Hernandez, NouriaGenes Dev 7:1291-3088946909Pubmed1997The general transcription factors of RNA polymerase II.Orphanides, GLagrange, TReinberg, DannyGenes Dev 10:2657-83inferred from electronic annotationEVIDENCE CODEECO:0000203Reactome Database ID Release 7510088329Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10088329ReactomeR-BTA-737791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-73779.1GENE ONTOLOGYGO:0006367gene ontology term for cellular processMIMI:0359Formation of the pre-initiation complex proceeds in five steps, recognition and binding of core promoter elements by TFIID, binding of TFIIA and TFIIB to the pol II promoter:TFIID complex, recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex, binding of TFIIE to the growing preinitiation complex, and formation of the closed pre-initiation complex (Orphanides et al. 1997).