BioPAX pathway converted from "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)" in the Reactome database. LEFT-TO-RIGHT 3.2.1.45 Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol) This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a> Glucosylceramide Glucocerebroside D-glucosyl-N-acylsphingosine D-glucosy-N-acylsphingosine Reactome DB_ID: 1861764 cytosol GENE ONTOLOGY GO:0005829 D-glucosyl-N-acylsphingosine [ChEBI:18368] D-glucosyl-N-acylsphingosine N-acyl-D-glucosylsphingosine Glucocerebroside Glucosylceramide ChEBI CHEBI:18368 Reactome Database ID Release 83 1861764 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=1861764 Reactome R-ALL-1861764 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-1861764.3 Reactome http://www.reactome.org H2O water Reactome DB_ID: 29356 water [ChEBI:15377] water ChEBI CHEBI:15377 Reactome Database ID Release 83 29356 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=29356 Reactome R-ALL-29356 5 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-29356.5 COMPOUND C00001 additional information MI MI:0361 Glc alpha-D-glucose Reactome DB_ID: 70113 alpha-D-glucose [ChEBI:17925] alpha-D-glucose ChEBI CHEBI:17925 Reactome Database ID Release 83 70113 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=70113 Reactome R-ALL-70113 3 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-70113.3 COMPOUND C00267 Ceramide N-acylsphingosine Reactome DB_ID: 194377 N-acylsphingosine [ChEBI:52639] N-acylsphingosine N-acylsphingosines ceramide d18:1(4c) ceramide ChEBI CHEBI:52639 Reactome Database ID Release 83 194377 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=194377 Reactome R-ALL-194377 2 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-ALL-194377.2 COMPOUND C00195 ACTIVATION GBA3 F6XBY5 Reactome DB_ID: 10090403 UniProt:F6XBY5 Canis familiaris NCBI Taxonomy 9615 UniProt F6XBY5 1 EQUAL 469 EQUAL Reactome Database ID Release 83 10090403 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10090403 Reactome R-CFA-1861749 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1861749.1 GENE ONTOLOGY GO:0004348 gene ontology term for cellular function MI MI:0355 Same Catalyst Activity Reactome Database ID Release 83 10090404 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10090404 Reactome Database ID Release 83 10090406 Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10090406 Reactome R-CFA-1861789 1 Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-CFA-1861789.1 Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003). 12594539 Pubmed 2003 Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans Nemeth, K Plumb, GW Berrin, JG Juge, N Jacob, Ralf Naim, HY Williamson, G Swallow, DM Kroon, PA Eur J Nutr 42:29-42 11784319 Pubmed 2002 Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides Berrin, JG McLauchlan, WR Needs, P Williamson, G Puigserver, A Kroon, PA Juge, N Eur J Biochem 269:249-58 inferred from electronic annotation EVIDENCE CODE ECO:0000203