BioPAX pathway converted from "RUNX3 regulates YAP1-mediated transcription" in the Reactome database.RUNX3 regulates YAP1-mediated transcriptionThis event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>LEFT-TO-RIGHTRUNX3 binds TEADs and YAP1This event has been computationally inferred from an event that has been demonstrated in another species.<p>The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.<p><a href='/electronic_inference_compara.html' target = 'NEW'>More details and caveats of the event inference in Reactome.</a> For details on PANTHER see also: <a href='http://www.pantherdb.org/about.jsp' target='NEW'>http://www.pantherdb.org/about.jsp</a>RUNX3A0A3Q1MYL2Reactome DB_ID: 10081755nucleoplasmGENE ONTOLOGYGO:0005654UniProt:A0A3Q1MYL2Bos taurusNCBI Taxonomy9913UniProtA0A3Q1MYL21EQUAL415EQUALReactome Database ID Release 7510081755Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10081755ReactomeR-BTA-88653931Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8865393.1Reactomehttp://www.reactome.orgYAP1:TEAD1,TEAD4,(TEAD2,TEAD3)Reactome DB_ID: 10084502Converted from EntitySet in ReactomeTEADsReactome DB_ID: 10060577TEAD1A0A3Q1N1G2Reactome DB_ID: 10060567UniProt:A0A3Q1N1G2UniProtA0A3Q1N1G21EQUAL426EQUALReactome Database ID Release 7510060567Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10060567ReactomeR-BTA-20327741Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2032774.1TEAD4A0A3Q1M163Reactome DB_ID: 10060575UniProt:A0A3Q1M163UniProtA0A3Q1M1631EQUAL434EQUALReactome Database ID Release 7510060575Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10060575ReactomeR-BTA-20327801Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2032780.1Reactome Database ID Release 7510060577Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10060577ReactomeR-BTA-20327731Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-2032773.11YAP1F1MK73Reactome DB_ID: 10054612UniProt:F1MK73UniProtF1MK731EQUAL504EQUALReactome Database ID Release 7510054612Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10054612ReactomeR-BTA-12533221Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-1253322.11Reactome Database ID Release 7510084502Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10084502ReactomeR-BTA-89516781Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951678.1RUNX3:YAP1:TEAD1,TEAD4,(TEAD2,TEAD3)Reactome DB_ID: 1008450411Reactome Database ID Release 7510084504Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10084504ReactomeR-BTA-89516791Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951679.1Reactome Database ID Release 7510084506Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10084506ReactomeR-BTA-89516761Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951676.1RUNX3 interacts with both YAP1 and TEAD proteins. The interaction with YAP1 involves the PY motif of RUNX3 and the WW domain of YAP1. The interaction with TEADs involves the Runt domain of RUNX3 and the DNA recognition helix of TEADs. RUNX3 was shown to directly interact with TEAD1 and TEAD4. Based on sequence similarity, it is highly probable that RUNX3 also interacts with TEAD2 and TEAD3. The interaction of RUNX3 with YAP1 and/or TEADs does not prevent formation of the YAP1:TEADs complex (Yagi et al. 1999, Qiao et al. 2015).26364597Pubmed2016RUNX3 is a novel negative regulator of oncogenic TEAD-YAP complex in gastric cancerQiao, YLin, S JChen, YVoon, D C-CZhu, FChuang, L S HWang, TTan, PLee, S CYeoh, K GSudol, MIto, YOncogene 35:2664-7410228168Pubmed1999A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activatorYagi, RChen, L FShigesada, KMurakami, YIto, YEMBO J. 18:2551-62inferred from electronic annotationEVIDENCE CODEECO:0000203Reactome Database ID Release 7510090435Database identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=10090435ReactomeR-BTA-89516711Reactome stable identifier. Use this URL to connect to the web page of this instance in Reactome: http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=R-BTA-8951671.1Association of RUNX3 with the TEADs:YAP1 complex inhibits loading of the TEADs:YAP1 to the CTGF promoter, thus negatively regulating transcription of the CTGF gene which encodes the Connective tissue growth factor (Yagi et al. 1999, Zhao et al. 2008, Qiao et al. 2016).18579750Pubmed2008TEAD mediates YAP-dependent gene induction and growth controlZhao, BYe, XinYu, JLi, LLi, WLi, SimingYu, JianjunLin, Jiandie DWang, Cun-YuChinnaiyan, Arul MLai, ZCGuan, KLGenes Dev. 22:1962-71